U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nvy nervy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37886, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nvyprovided by FlyBase
    Official Full Name
    nervyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005636
    Locus tag
    Dmel_CG3385
    See related
    AllianceGenome:FB:FBgn0005636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3385; Dmel\CG3385; Nvy
    Summary
    Predicted to enable transcription corepressor activity. Involved in axon guidance; chaeta morphogenesis; and circadian rhythm. Located in nucleus. Is expressed in several structures, including CNS glial cell; central nervous system; ganglia; neuroblasts; and sensory nervous system primordium. Orthologous to several human genes including CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nvy in Genome Data Viewer
    Location:
    60C5-60C6; 2-106 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24275734..24291084)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20163257..20178607)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4985 stem loop Neighboring gene Fatty acid transport protein 3 Neighboring gene beta-Tubulin at 60D

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers. Brody T, et al. BMC Genomics, 2008 Aug 1. PMID 18673565, Free PMC Article
    2. The LxxLL motif: a multifunctional binding sequence in transcriptional regulation. Plevin MJ, et al. Trends Biochem Sci, 2005 Feb. PMID 15691650
    3. The MTG proteins: chromatin repression players with a passion for networking. Rossetti S, et al. Genomics, 2004 Jul. PMID 15203199
    4. Semaphorin-1a functions as a guidance receptor in the Drosophila visual system. Cafferty P, et al. J Neurosci, 2006 Apr 12. PMID 16611816, Free PMC Article
    5. Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion". Ice RJ, et al. Science, 2005 Jul 22. PMID 16040690

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nervy
    Names
    CG3385-PA
    CG3385-PB
    CG3385-PC
    CG3385-PD
    nvy-PA
    nvy-PB
    nvy-PC
    nvy-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24275734..24291084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079117.4 → NP_523841.3  nervy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523841.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24037, Q86LF1, Q9W186
      Related
      FBpp0072174
      Conserved Domains (3) summary
      smart00549
      Location:213 → 304
      TAFH; TAF homology
      pfam01753
      Location:593 → 629
      zf-MYND; MYND finger
      pfam08788
      Location:454 → 482
      NHR2; NHR2 domain like

    2. NM_001274237.2 → NP_001261166.1  nervy, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEZ2, Q24037
      Conserved Domains (3) summary
      smart00549
      Location:213 → 304
      TAFH; TAF homology
      pfam01753
      Location:593 → 629
      zf-MYND; MYND finger
      pfam08788
      Location:454 → 482
      NHR2; NHR2 domain like

    3. NM_001274236.1 → NP_001261165.1  nervy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ8, Q24037
      Conserved Domains (3) summary
      smart00549
      Location:212 → 303
      TAFH; TAF homology
      pfam01753
      Location:592 → 628
      zf-MYND; MYND finger
      pfam08788
      Location:453 → 481
      NHR2; NHR2 domain like

    4. NM_001274235.1 → NP_001261164.1  nervy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ8, Q24037
      Conserved Domains (3) summary
      smart00549
      Location:212 → 303
      TAFH; TAF homology
      pfam01753
      Location:592 → 628
      zf-MYND; MYND finger
      pfam08788
      Location:453 → 481
      NHR2; NHR2 domain like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEZ2 A0A0B4KEZ2
    A0A0B4KFZ8 A0A0B4KFZ8
    Q24037 Q24037
    Q9W186 Q9W186

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools