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Conserved domains on  [gi|442624631|ref|NP_001261166|]
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nervy, isoform D [Drosophila melanogaster]

Protein Classification

zinc finger MYND domain-containing protein; SET and MYND domain-containing protein( domain architecture ID 10651065)

MYND (myeloid-Nervy-DEAF-1) domain-containing protein, defined by a C6HC zinc-chelating motif, does not bind DNA, but instead mediates interactions with other proteins| SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) and MYND (myeloid, Nervy, and DEAF-1) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 213-304 3.61e-40

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


:

Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 142.60  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624631   213 LVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALA 292
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 442624631   293 RATNQSALQYVT 304
Cdd:smart00549  81 RLIEQSPPQPLA 92
zf-MYND pfam01753
MYND finger;
593-629 3.75e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 3.75e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442624631  593 CWNCGRKATET--CSGCNMARYCSASCQYRDWDSHHQVC 629
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
NHR2 super family cl07409
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 454-482 2.16e-06

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


The actual alignment was detected with superfamily member pfam08788:

Pssm-ID: 430219  Cd Length: 67  Bit Score: 45.69  E-value: 2.16e-06
                          10        20
                  ....*....|....*....|....*....
gi 442624631  454 EEWKNIHTMLNCISAMVDKTKRAITILQQ 482
Cdd:pfam08788  16 DEWRHLDHLLNCIMDMVEKTRRSLTVLRR 44
 
Name Accession Description Interval E-value
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 213-304 3.61e-40

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 142.60  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624631   213 LVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALA 292
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 442624631   293 RATNQSALQYVT 304
Cdd:smart00549  81 RLIEQSPPQPLA 92
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 214-303 2.70e-30

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 114.29  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624631  214 VSKMRKFLGALVQFSQELgQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALAR 293
Cdd:pfam07531   2 VKKCKNFLSTLIKLAGEQ-SPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 442624631  294 ATNQSALQYV 303
Cdd:pfam07531  81 FIQQCPPQYL 90
zf-MYND pfam01753
MYND finger;
593-629 3.75e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 3.75e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442624631  593 CWNCGRKATET--CSGCNMARYCSASCQYRDWDSHHQVC 629
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 454-482 2.16e-06

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 45.69  E-value: 2.16e-06
                          10        20
                  ....*....|....*....|....*....
gi 442624631  454 EEWKNIHTMLNCISAMVDKTKRAITILQQ 482
Cdd:pfam08788  16 DEWRHLDHLLNCIMDMVEKTRRSLTVLRR 44
 
Name Accession Description Interval E-value
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 213-304 3.61e-40

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 142.60  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624631   213 LVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALA 292
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 442624631   293 RATNQSALQYVT 304
Cdd:smart00549  81 RLIEQSPPQPLA 92
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 214-303 2.70e-30

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 114.29  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624631  214 VSKMRKFLGALVQFSQELgQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALAR 293
Cdd:pfam07531   2 VKKCKNFLSTLIKLAGEQ-SPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 442624631  294 ATNQSALQYV 303
Cdd:pfam07531  81 FIQQCPPQYL 90
zf-MYND pfam01753
MYND finger;
593-629 3.75e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 3.75e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442624631  593 CWNCGRKATET--CSGCNMARYCSASCQYRDWDSHHQVC 629
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 454-482 2.16e-06

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 45.69  E-value: 2.16e-06
                          10        20
                  ....*....|....*....|....*....
gi 442624631  454 EEWKNIHTMLNCISAMVDKTKRAITILQQ 482
Cdd:pfam08788  16 DEWRHLDHLLNCIMDMVEKTRRSLTVLRR 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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