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    Ints7 integrator complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 77065, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ints7provided by MGI
    Official Full Name
    integrator complex subunit 7provided by MGI
    Primary source
    MGI:MGI:1924315
    See related
    Ensembl:ENSMUSG00000037461 AllianceGenome:MGI:1924315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    int7; 5930412E23Rik
    Summary
    Predicted to be involved in DNA damage checkpoint signaling; cellular response to ionizing radiation; and snRNA 3'-end processing. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of integrator complex. Is expressed in central nervous system and retina. Orthologous to human INTS7 (integrator complex subunit 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.5), thymus adult (RPKM 13.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ints7 in Genome Data Viewer
    Location:
    1 H6; 1 96.51 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191307652..191355802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191575540..191623690)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03433 Neighboring gene STARR-positive B cell enhancer ABC_E4408 Neighboring gene predicted gene, 32200 Neighboring gene predicted gene, 32334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:193343672-193343855 Neighboring gene STARR-positive B cell enhancer ABC_E803 Neighboring gene STARR-positive B cell enhancer ABC_E1579 Neighboring gene denticleless E3 ubiquitin protein ligase Neighboring gene STARR-positive B cell enhancer mm9_chr1:193423192-193423493 Neighboring gene STARR-seq mESC enhancer starr_03434 Neighboring gene predicted gene, 39741 Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene predicted gene, 22446

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling  
    involved_in DNA damage response  
    involved_in cellular response to ionizing radiation  
    involved_in snRNA 3'-end processing  
    involved_in snRNA processing  
    involved_in snRNA processing  
    Component Evidence Code Pubs
    located_in chromosome  
    located_in chromosome  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of integrator complex  
    part_of integrator complex  
    part_of integrator complex  
    located_in nuclear body  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    integrator complex subunit 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306203.1NP_001293132.1  integrator complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001293132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK085336, AK086462, BP758668, CD348032, CK635124
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6
    2. NM_001306204.1NP_001293133.1  integrator complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001293133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6
    3. NM_178632.6NP_848747.4  integrator complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_848747.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
      Consensus CDS
      CCDS35825.1
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6
      UniProtKB/TrEMBL
      A0A0R4J0E4
      Related
      ENSMUSP00000036277.6, ENSMUST00000045450.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      191307652..191355802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_865812.3 RNA Sequence

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