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    Prrg1 proline rich and Gla domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prrg1provided by RGD
    Official Full Name
    proline rich and Gla domain 1provided by RGD
    Primary source
    RGD:1561320
    See related
    EnsemblRapid:ENSRNOG00000089620 AllianceGenome:RGD:1561320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561320
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRRG1 (proline rich and Gla domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 70.9), Adrenal (RPKM 52.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prrg1 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (46381329..46493677, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (42494256..42606612, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (45698240..45806238, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ferritin, heavy polypeptide-like 17, member F like Neighboring gene SIN3-HDAC complex-associated factor-like Neighboring gene tubulin, beta 4B class IVb, pseudogene 1 Neighboring gene uncharacterized LOC120099307 Neighboring gene ring finger protein 41, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 1
    Names
    proline rich Gla (G-carboxyglutamic acid) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191888.2 → NP_001178817.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A9I3
      Related
      ENSRNOP00000107597.1, ENSRNOT00000168871.1
      Conserved Domains (1) summary
      smart00069
      Location:2 → 64
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    2. NM_001434274.1 → NP_001421203.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A9I3, A0A8I6ACL3

    3. NM_001434275.1 → NP_001421204.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A9I3, D3ZUF5

    4. NM_001434276.1 → NP_001421205.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A9I3, A0A8I6ACL3

    5. NM_001434277.1 → NP_001421206.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A9I3, A0A8I6ACL3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      46381329..46493677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256965.5 → XP_006257027.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X2

      Conserved Domains (1) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    2. XM_006256963.4 → XP_006257025.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X1

      Conserved Domains (1) summary
      smart00069
      Location:6 → 69
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    3. XM_017602107.3 → XP_017457596.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X2

      Related
      ENSRNOP00000099645.1, ENSRNOT00000157302.1
      Conserved Domains (1) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    4. XM_017602106.2 → XP_017457595.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X2

      Related
      ENSRNOP00000108965.1, ENSRNOT00000125245.1
      Conserved Domains (1) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    5. XM_063280140.1 → XP_063136210.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9I3

    6. XM_063280139.1 → XP_063136209.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I3, D3ZUF5
      Related
      ENSRNOP00000106134.1, ENSRNOT00000129443.1

    7. XM_063280141.1 → XP_063136211.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9I3

    8. XM_017602104.2 → XP_017457593.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I3, D3ZUF5
      Conserved Domains (1) summary
      smart00069
      Location:6 → 69
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    9. XM_063280142.1 → XP_063136212.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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