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    CG42709 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42709provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261674
    Locus tag
    Dmel_CG42709
    See related
    AllianceGenome:FB:FBgn0261674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17667; Dmel\CG42709; EP(3)3622; EP3622
    Old locus tag
    Dmel_CG17667
    Summary
    Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; embryonic/larval posterior spiracle; extraembryonic structure; and larval pericardial cell. Orthologous to human LRTM2 (leucine rich repeats and transmembrane domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42709 in Genome Data Viewer
    Location:
    69E2-69E3; 3-39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12790192..12796084)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12783292..12789184)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 1 Neighboring gene antisense RNA:CR46251 Neighboring gene Sin3A-associated protein 130 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase. Ahantarig A, et al. Mol Biol Rep, 2009 Jul. PMID 18636236, Free PMC Article
    2. Unc-51 controls active zone density and protein composition by downregulating ERK signaling. Wairkar YP, et al. J Neurosci, 2009 Jan 14. PMID 19144852, Free PMC Article
    3. Dysregulated glial genes in Alzheimer's disease are essential for homeostatic plasticity: Evidence from integrative epigenetic and single cell analyses. Cai Y, et al. Aging Cell, 2023 Nov. PMID 37712202, Free PMC Article
    4. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Toda H, et al. Genes Dev, 2008 Dec 1. PMID 19056884, Free PMC Article
    5. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. Vichas A, et al. J Cell Biol, 2015 Dec 7. PMID 26644515, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster
      Title: Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42709-PA
    CG42709-PB
    CG42709-PC
    CG42709-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12790192..12796084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140343.4 → NP_648600.1  uncharacterized protein Dmel_CG42709, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE1, Q95TK3, Q9VU13
      Related
      FBpp0292105
      Conserved Domains (3) summary
      cd00116
      Location:150 → 225
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:128 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:126 → 182
      LRR_8; Leucine rich repeat

    2. NM_001169963.2 → NP_001163434.1  uncharacterized protein Dmel_CG42709, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE1, Q95TK3, Q9VU13
      Conserved Domains (3) summary
      cd00116
      Location:150 → 225
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:128 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:126 → 182
      LRR_8; Leucine rich repeat

    3. NM_001300122.1 → NP_001287051.1  uncharacterized protein Dmel_CG42709, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE1, X2JCD3
      Conserved Domains (3) summary
      cd00116
      Location:150 → 225
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:128 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:126 → 182
      LRR_8; Leucine rich repeat

    4. NM_168516.3 → NP_729833.1  uncharacterized protein Dmel_CG42709, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE1, Q95TK3, Q9VU13
      Related
      FBpp0292106
      Conserved Domains (3) summary
      cd00116
      Location:150 → 225
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:128 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:126 → 182
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU13 Q9VU13
    X2JCD3 X2JCD3

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