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Conserved domains on  [gi|24663477|ref|NP_729833|]
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uncharacterized protein Dmel_CG42709, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-300 5.77e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 127 IDLSHNVIAELrPEDFANLSRAVEINLNHNLISSIdKDVFQGSERLKRLRLANNRLTKIdPDTFAAAKELTLLDLSNNTI 206
Cdd:COG4886 164 LDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 207 TQRldGSFLNQPDLVEFSCVNCSWTELPEQTfqNMSGLEVLRLNKNDFKqQINTKAFSPLTKIIKLKLPELEQQNIEELC 286
Cdd:COG4886 241 TDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                       170
                ....*....|....
gi 24663477 287 SLLTSIDTISFLNY 300
Cdd:COG4886 316 LLLLLTTLLLLLLL 329
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-300 5.77e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 127 IDLSHNVIAELrPEDFANLSRAVEINLNHNLISSIdKDVFQGSERLKRLRLANNRLTKIdPDTFAAAKELTLLDLSNNTI 206
Cdd:COG4886 164 LDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 207 TQRldGSFLNQPDLVEFSCVNCSWTELPEQTfqNMSGLEVLRLNKNDFKqQINTKAFSPLTKIIKLKLPELEQQNIEELC 286
Cdd:COG4886 241 TDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                       170
                ....*....|....
gi 24663477 287 SLLTSIDTISFLNY 300
Cdd:COG4886 316 LLLLLTTLLLLLLL 329
LRR_8 pfam13855
Leucine rich repeat;
150-204 9.28e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.28e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24663477   150 EINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNN 204
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-229 1.84e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  127 IDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTI 206
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559

                         90       100
                 ....*....|....*....|...
gi 24663477  207 TQRLDGSFLNQPDLVEfscVNCS 229
Cdd:PLN00113 560 SGEIPKNLGNVESLVQ---VNIS 579
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-209 1.39e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 126 IIDLSHNVIAELrpEDFANLSRAVEINLNHNLISSID--KDVFQGSERLKRLRLANNRLTKIDP--DTF-AAAKELTLLD 200
Cdd:cd21340 124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVLD 201


                ....*....
gi 24663477 201 LSNNTITQR 209
Cdd:cd21340 202 GKEITDTER 210
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-300 5.77e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 127 IDLSHNVIAELrPEDFANLSRAVEINLNHNLISSIdKDVFQGSERLKRLRLANNRLTKIdPDTFAAAKELTLLDLSNNTI 206
Cdd:COG4886 164 LDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 207 TQRldGSFLNQPDLVEFSCVNCSWTELPEQTfqNMSGLEVLRLNKNDFKqQINTKAFSPLTKIIKLKLPELEQQNIEELC 286
Cdd:COG4886 241 TDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                       170
                ....*....|....
gi 24663477 287 SLLTSIDTISFLNY 300
Cdd:COG4886 316 LLLLLTTLLLLLLL 329
LRR_8 pfam13855
Leucine rich repeat;
150-204 9.28e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.28e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24663477   150 EINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNN 204
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
126-182 4.78e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 4.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663477   126 IIDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRL 182
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
171-254 9.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 9.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477   171 RLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQrldgsflnqpdlvefscvncswteLPEQTFQNMSGLEVLRLN 250
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT------------------------LSPGAFSGLPSLRYLDLS 57


                  ....
gi 24663477   251 KNDF 254
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-229 1.84e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  127 IDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTI 206
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559

                         90       100
                 ....*....|....*....|...
gi 24663477  207 TQRLDGSFLNQPDLVEfscVNCS 229
Cdd:PLN00113 560 SGEIPKNLGNVESLVQ---VNIS 579
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-274 2.20e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 2.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 132 NVIAELRPEDFANLSRAVEINLNHNlissidkDVFQGSERLKRLRLANNRLTKIdPDTFAAAKELTLLDLSNNTITQrLD 211
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD-LP 152

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24663477 212 GSFLNQPDLVEFSCVNCSWTELPEqTFQNMSGLEVLRLNKNdfkqQINT--KAFSPLTKIIKLKL 274
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN----QITDlpEPLGNLTNLEELDL 212
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-247 1.60e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  119 DMPkTAAIIDLSHNVIAELRPEDFANlSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTL 198
Cdd:PLN00113 450 DMP-SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVS 527

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 24663477  199 LDLSNNTITQRLDGSFLNQPDLvefSCVNCSWTELPEQTFQNMSGLEVL 247
Cdd:PLN00113 528 LDLSHNQLSGQIPASFSEMPVL---SQLDLSQNQLSGEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-293 3.24e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  116 VPLDMPK--TAAIIDLSHNVIAELRPEDFANLSRAVEINLNHN-LISSIDKDVfQGSERLKRLRLANNRLTKIDPDTFAA 192
Cdd:PLN00113 348 IPKNLGKhnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNsLEGEIPKSL-GACRSLRRVRLQDNSFSGELPSEFTK 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  193 AKELTLLDLSNNTITQRLDGSFLNQPDLVEFS-CVNCSWTELPEqtFQNMSGLEVLRLNKNDFKQQINTKaFSPLTKIIK 271
Cdd:PLN00113 427 LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSlARNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPRK-LGSLSELMQ 503

                        170       180
                 ....*....|....*....|....*.
gi 24663477  272 LKLPELEQQNI--EEL--CSLLTSID 293
Cdd:PLN00113 504 LKLSENKLSGEipDELssCKKLVSLD 529
LRR_9 pfam14580
Leucine-rich repeat;
127-209 9.36e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477   127 IDLSHNVIAELrpEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKI-DPDTFAAAKELTLLDLSNNT 205
Cdd:pfam14580  47 IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSLLRNP 124


                  ....
gi 24663477   206 ITQR 209
Cdd:pfam14580 125 VTNK 128
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 171-212 1.29e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24663477   171 RLKRLRLANNRLTKIDPdtFAAAKELTLLDLSNNTITQRLDG 212
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-209 1.39e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 126 IIDLSHNVIAELrpEDFANLSRAVEINLNHNLISSID--KDVFQGSERLKRLRLANNRLTKIDP--DTF-AAAKELTLLD 200
Cdd:cd21340 124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVLD 201


                ....*....
gi 24663477 201 LSNNTITQR 209
Cdd:cd21340 202 GKEITDTER 210
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-258 2.93e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  127 IDLS-HNVIAELRPEDFaNLSRAVEINL-NHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAkeLTLLDLSNN 204
Cdd:PLN00113  74 IDLSgKNISGKISSAIF-RLPYIQTINLsNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNN 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24663477  205 TITQRLD---GSF--LNQPDLVEfscvNCSWTELPeQTFQNMSGLEVLRLNKNDFKQQI 258
Cdd:PLN00113 151 MLSGEIPndiGSFssLKVLDLGG----NVLVGKIP-NSLTNLTSLEFLTLASNQLVGQI 204
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 150-225 3.69e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 3.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477 150 EINLNHNLISS-----IDKDVFQGSERLKRLRLANNRLTKIDPDTFA----AAKELTLLDLSNNTITQrlDGSFLNQPDL 220
Cdd:cd00116 225 VLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE--EGAQLLAESL 302


                ....*
gi 24663477 221 VEFSC 225
Cdd:cd00116 303 LEPGN 307
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-285 5.36e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  127 IDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNT- 205
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNl 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663477  206 ---ITQRLDG-SFLNQPDLVefscVNCSWTELPeQTFQNMSGLEVLRLNKNDFKQQINTKAFSpLTKIIKLKL------- 274
Cdd:PLN00113 225 sgeIPYEIGGlTSLNHLDLV----YNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFS-LQKLISLDLsdnslsg 298

                        170
                 ....*....|....*
gi 24663477  275 --PEL--EQQNIEEL 285
Cdd:PLN00113 299 eiPELviQLQNLEIL 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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