flr flare [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: flrprovided by FlyBase
Official Full Name: flareprovided by FlyBase
Primary source: FLYBASE:FBgn0260049
Locus tag: Dmel_CG10724
See related: AllianceGenome:FB:FBgn0260049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aip1; Aip1; AIP1; CG10724; Dmel\CG10724; Flare
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including actin cytoskeleton organization; epithelial cell differentiation; and regulation of actin filament organization. Located in cytoskeleton. Is expressed in several structures, including adult head; adult heart; germline cell; larval muscle cell; and mesoderm. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70A8-70B1; 3-40 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (13412843..13416453)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (13405943..13409553)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that actin-interacting protein 1 (AIP1) and twinstar protein (Drosophila cofilin gene) achieve an optimal balance between resistance to tissue tension and morphogenesis.
Title: AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Title: AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: flare

Names: AIP1; CG10724-PA; CG10724-PB; actin interacting protein 1; actin-interacting protein 1; flare hair; flare-3; flr-PA; flr-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

13412843..13416453

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140385.4 → NP_648642.1 flare, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648642.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IQJ6, Q9VU68

Related

FBpp0075581

Conserved Domains (4) summary

COG2319
Location:26 → 557

WD40; WD40 repeat [General function prediction only]

cd00200
Location:59 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:68 → 106

7WD40; WD40 repeat [structural motif]

cl02567
Location:317 → 607

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_168543.2 → NP_729891.1 flare, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729891.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV50

Related

FBpp0075582

Conserved Domains (4) summary

COG2319
Location:1 → 553

WD40; WD40 repeat [General function prediction only]

cd00200
Location:55 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:64 → 102

7WD40; WD40 repeat [structural motif]

cl02567
Location:313 → 603

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...