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Conserved domains on  [gi|21356527|ref|NP_648642|]
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flare, isoform A [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-397 5.19e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 5.19e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  16 ATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVN 95
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  96 KEHLLknEFQPIAGPIKDISWSPDNQRIVAVGEGRErfGHVFMSETGTSVGEISGQSKSINSADFRPARPfRIVTGSEDN 175
Cdd:COG2319 110 GLLLR--TLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 176 TIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLL 255
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSPDGRLLA 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 256 TCSGDKTCRLWTVESRELVSEFVmGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPsKPLRVVKGHNKPITVLGLSD 335
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSP 340

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356527 336 DRSTIYTGSHDGVVTNWNSGSGTNDRiTGTGHGNQINGIAAW--GDFVYTCGIDDSLRQFSVEG 397
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLR-TLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 488-607 4.59e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 488 HLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHnKEWGfHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAK 567
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21356527 568 HTIIKnAHpQSQITRLVWLDNNTVIST-GQDCNTKVWHVEN 607
Cdd:cd00200  86 VRTLT-GH-TSYVSSVAFSPDGRILSSsSRDKTIKVWDVET 124
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-397 5.19e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 5.19e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  16 ATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVN 95
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  96 KEHLLknEFQPIAGPIKDISWSPDNQRIVAVGEGRErfGHVFMSETGTSVGEISGQSKSINSADFRPARPfRIVTGSEDN 175
Cdd:COG2319 110 GLLLR--TLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 176 TIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLL 255
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSPDGRLLA 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 256 TCSGDKTCRLWTVESRELVSEFVmGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPsKPLRVVKGHNKPITVLGLSD 335
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSP 340

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356527 336 DRSTIYTGSHDGVVTNWNSGSGTNDRiTGTGHGNQINGIAAW--GDFVYTCGIDDSLRQFSVEG 397
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLR-TLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 1.43e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.43e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  59 VYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLKNEFQpiAGPIKDISWSPDNQRIVAVGEgrERFGHVFM 138
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSS--DKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 139 SETGTSVGEISGQSKSINSADFRPARPFrIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGK 218
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 219 VFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFvmgtTVDDQQV-SCLWQGDNL 297
Cdd:cd00200 159 IKLWDLRTGKCVATL--TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL----RGHENGVnSVAFSPDGY 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21356527 298 ITVSLS--GVITYLNVADPsKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWN 353
Cdd:cd00200 233 LLASGSedGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 488-607 4.59e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 488 HLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHnKEWGfHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAK 567
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21356527 568 HTIIKnAHpQSQITRLVWLDNNTVIST-GQDCNTKVWHVEN 607
Cdd:cd00200  86 VRTLT-GH-TSYVSSVAFSPDGRILSSsSRDKTIKVWDVET 124
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 211-372 8.55e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.48  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  211 ASAGFDGKVFLYDGTSSELVGEFGSpaHKGGVYALAW-KPDSTQLLTCSGDKTCRLWTVESRelVSefvMGTTVDDQQVS 289
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKE--HEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQG--VS---IGTIKTKANIC 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  290 CLW----QGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDrSTIYTGSHDGVVTNWN---SGSGTNDRI 362
Cdd:PLN00181 622 CVQfpseSGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDlsmSISGINETP 700

                        170
                 ....*....|..
gi 21356527  363 --TGTGHGNQIN 372
Cdd:PLN00181 701 lhSFMGHTNVKN 712
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 532-561 4.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.26e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 21356527    532 HSARVNTVAWSPNSLLVASGSLDTTIIIWS 561
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-266 4.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.77e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21356527   236 PAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-266 5.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 5.45e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21356527    236 PAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
532-561 9.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.86e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 21356527   532 HSARVNTVAWSPNSLLVASGSLDTTIIIWS 561
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 439-570 9.69e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 9.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  439 KIFSLPIKYEAssiAVN-ADTSDVAV------------------GGDDQkLHIYTLKGGVLEPKVELDHLGAVTDVSYSP 499
Cdd:COG4946  323 EVFTVPAEKGP---TRNlTNTPGVRErlpawspdgksiayfsdaSGEYE-LYIAPADGSGEPKQLTLGDLGRVFNPVWSP 398

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356527  500 DLKYLVACDAHRKVVLYSVEEYKP---AHNKEWGfhsaRVNTVAWSPNS-LLVASGSLDTT---IIIWSVANPAKHTI 570
Cdd:COG4946  399 DGKKIAFTDNRGRLWVVDLASGKVrkvDTDGYGD----GISDLAWSPDSkWLAYSKPGPNQlsqIFLYDVETGKTVQL 472
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-397 5.19e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 5.19e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  16 ATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVN 95
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  96 KEHLLknEFQPIAGPIKDISWSPDNQRIVAVGEGRErfGHVFMSETGTSVGEISGQSKSINSADFRPARPfRIVTGSEDN 175
Cdd:COG2319 110 GLLLR--TLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 176 TIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLL 255
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSPDGRLLA 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 256 TCSGDKTCRLWTVESRELVSEFVmGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPsKPLRVVKGHNKPITVLGLSD 335
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSP 340

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356527 336 DRSTIYTGSHDGVVTNWNSGSGTNDRiTGTGHGNQINGIAAW--GDFVYTCGIDDSLRQFSVEG 397
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLR-TLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 1.43e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.43e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  59 VYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLKNEFQpiAGPIKDISWSPDNQRIVAVGEgrERFGHVFM 138
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSS--DKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 139 SETGTSVGEISGQSKSINSADFRPARPFrIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGK 218
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 219 VFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFvmgtTVDDQQV-SCLWQGDNL 297
Cdd:cd00200 159 IKLWDLRTGKCVATL--TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL----RGHENGVnSVAFSPDGY 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21356527 298 ITVSLS--GVITYLNVADPsKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWN 353
Cdd:cd00200 233 LLASGSedGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-564 6.31e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.79  E-value: 6.31e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  46 VIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLknEFQPIAGPIKDISWSPDNQRIVA 125
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA--TLLGHTAAVLSVAFSPDGRLLAS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 126 VGEGRERfgHVFMSETGTSVGEISGQSKSINSADFRPARPfRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSP 205
Cdd:COG2319  96 ASADGTV--RLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 206 DGKFFASAGFDGKVFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRelvsefvmgttvdd 285
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-------------- 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 286 qqvsclwqgdnlitvslsgvitylnvadpsKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTNDRiTGT 365
Cdd:COG2319 237 ------------------------------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR-TLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 366 GHGNQINGIAawgdfvytcgiddslrqFSVEGNSytdyvvklncqprglailrneniialacikeltlvqdqkkifslpi 445
Cdd:COG2319 286 GHSGGVNSVA-----------------FSPDGKL---------------------------------------------- 302

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 446 kyeassiavnadtsdVAVGGDDQKLHIYTLKGGVLEPKVElDHLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAH 525
Cdd:COG2319 303 ---------------LASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                       490       500       510
                ....*....|....*....|....*....|....*....
gi 21356527 526 nkEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVAN 564
Cdd:COG2319 367 --TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
73-607 2.09e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 2.09e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  73 SPSGFYIASGDASGKIRIWDTVNKEHLLknEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVfmSETGTSVGEISGQS 152
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD--AAAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 153 KSINSADFRPARPfRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGE 232
Cdd:COG2319  79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 233 FgsPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRelvsefvmgttvddqqvsclwqgdnlitvslsgvitylnva 312
Cdd:COG2319 158 L--TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----------------------------------------- 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 313 dpsKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTnDRITGTGHGNQINGIAawgdfvytcgiddslrq 392
Cdd:COG2319 195 ---KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVA----------------- 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 393 FSVEGNSytdyvvklncqprglailrneniialacikeltlvqdqkkifslpikyeassiavnadtsdVAVGGDDQKLHI 472
Cdd:COG2319 254 FSPDGRL-------------------------------------------------------------LASGSADGTVRL 272

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 473 YTLKGGVLEPKVElDHLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHnkEWGFHSARVNTVAWSPNSLLVASGS 552
Cdd:COG2319 273 WDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGAVRSVAFSPDGKTLASGS 349

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21356527 553 LDTTIIIWSVANPAKHTIIKnAHpQSQITRLVWL-DNNTVISTGQDCNTKVWHVEN 607
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLT-GH-TGAVTSVAFSpDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-561 3.71e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 3.71e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 144 SVGEISGQSKSINSADFRPARPFrIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYD 223
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 224 GTSSELVGEFGSpaHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRelvsefvmgttvddqqvsclwqgdnlitvsls 303
Cdd:cd00200  80 LETGECVRTLTG--HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 304 gvitylnvadpsKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTNDRiTGTGHGNQINgiaawgdfvyt 383
Cdd:cd00200 126 ------------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTGEVN----------- 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 384 cgiddslrqfsvegnsytdyvvklncqprglailrneniialacikeltlvqdqkkifslpikyeasSIAVNADTSDVAV 463
Cdd:cd00200 182 -------------------------------------------------------------------SVAFSPDGEKLLS 194

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 464 GGDDQKLHIYTLKGGvlEPKVELD-HLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPaHNKEWGfHSARVNTVAWS 542
Cdd:cd00200 195 SSSDGTIKLWDLSTG--KCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSG-HTNSVTSLAWS 270

                       410
                ....*....|....*....
gi 21356527 543 PNSLLVASGSLDTTIIIWS 561
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 44-266 3.24e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.08  E-value: 3.24e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  44 NSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEhlLKNEFQPIAGPIKDISWSPDNQRI 123
Cdd:cd00200  73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 124 VAVgeGRERFGHVFMSETGTSVGEISGQSKSINSADFRPARpFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRY 203
Cdd:cd00200 151 ASS--SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21356527 204 SPDGKFFASAGFDGKVFLYDGTSSELVGEFgsPAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 488-607 4.59e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 488 HLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHnKEWGfHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAK 567
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21356527 568 HTIIKnAHpQSQITRLVWLDNNTVIST-GQDCNTKVWHVEN 607
Cdd:cd00200  86 VRTLT-GH-TSYVSSVAFSPDGRILSSsSRDKTIKVWDVET 124
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 211-372 8.55e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.48  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  211 ASAGFDGKVFLYDGTSSELVGEFGSpaHKGGVYALAW-KPDSTQLLTCSGDKTCRLWTVESRelVSefvMGTTVDDQQVS 289
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKE--HEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQG--VS---IGTIKTKANIC 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  290 CLW----QGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDrSTIYTGSHDGVVTNWN---SGSGTNDRI 362
Cdd:PLN00181 622 CVQfpseSGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDlsmSISGINETP 700

                        170
                 ....*....|..
gi 21356527  363 --TGTGHGNQIN 372
Cdd:PLN00181 701 lhSFMGHTNVKN 712
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 532-561 4.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.26e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 21356527    532 HSARVNTVAWSPNSLLVASGSLDTTIIIWS 561
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-266 4.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.77e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21356527   236 PAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-266 5.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 5.45e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21356527    236 PAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-223 8.55e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 8.55e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21356527    184 PFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
532-561 9.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.86e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 21356527   532 HSARVNTVAWSPNSLLVASGSLDTTIIIWS 561
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-92 3.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 21356527     59 VYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWD 92
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
185-223 7.83e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21356527   185 FKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYD 223
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-353 3.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21356527    314 PSKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWN 353
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 150-303 6.39e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  150 GQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQD-------HSRFVQAVRYSPDGK-FFASAGFDGKVFL 221
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDpivhlqgHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  222 YD---GTSSELVGefgspAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFVMGTTVDDQQvsCLW--QGDN 296
Cdd:PTZ00421 153 WDverGKAVEVIK-----CHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQR--CLWakRKDL 225


                 ....*..
gi 21356527  297 LITVSLS 303
Cdd:PTZ00421 226 IITLGCS 232
WD40 pfam00400
WD domain, G-beta repeat;
59-92 7.23e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 21356527    59 VYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWD 92
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 33-124 8.61e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 8.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527    33 PKGKNFLYTNGnsviirniENPAIADVYtEHSCAV---------NVAKYSPSGFYIAS---GDASGKIRIWDTVNKEHLL 100
Cdd:pfam08662  69 PNGKEFAVIYG--------YMPAKVSFF-DLKGNVihsfgeqprNTIFWSPFGRLVLLagfGNLAGDIEFWDVVNKKKIA 139

                          90       100
                  ....*....|....*....|....
gi 21356527   101 KNEfqpiAGPIKDISWSPDNQRIV 124
Cdd:pfam08662 140 TAE----ASNATLCEWSPDGRYFL 159
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 201-293 9.17e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 9.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527   201 VRYSPDGKFFASAGFDGKVFLYDgTSSELVGEFGSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFvmg 280
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHR-LNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF--- 76

                          90
                  ....*....|....
gi 21356527   281 tTVDDQQVSCL-WQ 293
Cdd:pfam12894  77 -SAGSDLITCLgWG 89
WD40 pfam00400
WD domain, G-beta repeat;
315-353 1.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21356527   315 SKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWN 353
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 455-606 1.68e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527   455 NADTSDVAVGGDdQKLHIYTLKGGVLEpKVELDHLGAVTDVSYSPDLK--YLVACDAHRKVVLYSVEeYKPAHNkewgFH 532
Cdd:pfam08662  27 DVDKTGKSYYGE-TNLYLIGETGGPDC-VVELDKEGPIHDVAWSPNGKefAVIYGYMPAKVSFFDLK-GNVIHS----FG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527   533 SARVNTVAWSPNSLLVAS---GSLDTTIIIWSVANpaKHTIIKNAHPQSqiTRLVWLDNNTVISTGQ-------DCNTKV 602
Cdd:pfam08662 100 EQPRNTIFWSPFGRLVLLagfGNLAGDIEFWDVVN--KKKIATAEASNA--TLCEWSPDGRYFLTATtaprlrvDNGFKI 175


                  ....
gi 21356527   603 WHVE 606
Cdd:pfam08662 176 WHYN 179
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 198-247 1.80e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 1.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 21356527   198 VQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVgeFGSPAHKGGVYALAW 247
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV--HHFSAGSDLITCLGW 88
8prop_hemeD1_cyt_cd1-like cd20783
eight-bladed heme d1-binding beta-propeller domain and similar proteins; Cytochrome cd1 (cyt ...
 77-234 4.32e-03

eight-bladed heme d1-binding beta-propeller domain and similar proteins; Cytochrome cd1 (cyt cd1) nitrite reductase catalyzes in vitro the reduction of molecular oxygen to water and the reduction of nitrite to nitric oxide). It is a dimer of two identical subunits of 60 kDa, each containing one c and one d1 heme group. The c heme is the electron accepting pole of the molecule and is reduced in vitro by either azurin or cytochrome c551. The d1 heme is the site where nitrite, and oxygen reduction occur. NiR is a key denitrification enzyme, which controls the rate of the production of toxic nitric oxide (NO) and ultimately regulates the release of NO into the atmosphere. The two types of heme are located in separate domains whose arrangement suggests a mechanism requiring domain movement during catalysis.


Pssm-ID: 467727 [Multi-domain]  Cd Length: 388  Bit Score: 39.68  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  77 FYIASgDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQR---IVAVGEGRerfGHVFMSETGTSVGEI--SGQ 151
Cdd:cd20783 213 FYLAS-QTDNWMAAIDVATMKIVAKIPTGDKPHPGSGAVWEADGKEyaaTVHAGEGK---VTIWDLDTNEIVGEVptSGP 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527 152 SKSINSADFRPARPFRIVTGSEDNTIAVFE-GPPFKFKMTKQDHSRFVQAvRYSPDGKF-FASAGFDGKVFLYDGTSSEL 229
Cdd:cd20783 289 GLFIRTTENMPYVWADSMFAPEPNEITVHEkAPPFKVVKRITDGTRTLHP-EPTADGKYvYVSDWDGNVVRVYDAETLEL 367


                ....*
gi 21356527 230 VGEFG 234
Cdd:cd20783 368 VKEIT 372
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 439-570 9.69e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 9.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356527  439 KIFSLPIKYEAssiAVN-ADTSDVAV------------------GGDDQkLHIYTLKGGVLEPKVELDHLGAVTDVSYSP 499
Cdd:COG4946  323 EVFTVPAEKGP---TRNlTNTPGVRErlpawspdgksiayfsdaSGEYE-LYIAPADGSGEPKQLTLGDLGRVFNPVWSP 398

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356527  500 DLKYLVACDAHRKVVLYSVEEYKP---AHNKEWGfhsaRVNTVAWSPNS-LLVASGSLDTT---IIIWSVANPAKHTI 570
Cdd:COG4946  399 DGKKIAFTDNRGRLWVVDLASGKVrkvDTDGYGD----GISDLAWSPDSkWLAYSKPGPNQlsqIFLYDVETGKTVQL 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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