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    M6 M6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40383, updated on 17-Dec-2024

    Summary

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    Official Symbol
    M6provided by FlyBase
    Official Full Name
    M6provided by FlyBase
    Primary source
    FLYBASE:FBgn0037092
    Locus tag
    Dmel_CG7540
    See related
    AllianceGenome:FB:FBgn0037092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7540; dM6a; Dmel\CG7540; m6
    Summary
    Involved in several processes, including maintenance of epithelial integrity, open tracheal system; positive phototaxis; and tricellular tight junction assembly. Located in lateral plasma membrane and tricellular tight junction. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and ovary. Used to study intellectual disability. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to several human genes including GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    Location:
    78D4-78D4; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21507852..21512749)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21500952..21505849)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43933 Neighboring gene Hormone-receptor-like in 78 Neighboring gene Golgi complex-localized glycoprotein 1 Neighboring gene Esterase Q Neighboring gene Sak kinase Neighboring gene Cyclin-dependent kinase 12 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered GPM6A/M6 dosage impairs cognition and causes phenotypes responsive to cholesterol in human and Drosophila. Gregor A, et al. Hum Mutat, 2014 Dec. PMID 25224183
    2. A role for the membrane protein M6 in the Drosophila visual system. Zappia MP, et al. BMC Neurosci, 2012 Jul 4. PMID 22762289, Free PMC Article
    3. The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. Stecca B, et al. J Neurosci, 2000 Jun 1. PMID 10818135, Free PMC Article
    4. Palmitoylation of proteolipid protein M6 promotes tricellular junction assembly in epithelia of Drosophila. Schleutker R, et al. J Cell Sci, 2024 Mar 15. PMID 38345097
    5. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Wittek A, et al. Curr Biol, 2020 Nov 2. PMID 32857972

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
      Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
    2. Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
      Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
    3. This study demonistrated that M6 is key in cell remodeling processes underlying visual system function.
      Title: A role for the membrane protein M6 in the Drosophila visual system.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tricellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    M6
    Names
    CG7540-PB
    CG7540-PC
    CG7540-PD
    CG7540-PE
    CG7540-PF
    CG7540-PG
    M6-PB
    M6-PC
    M6-PD
    M6-PE
    M6-PF
    M6-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21507852..21512749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275237.1 → NP_001262166.1  M6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGC0
      Conserved Domains (1) summary
      pfam01275
      Location:123 → 345
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    2. NM_001275236.1 → NP_001262165.1  M6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFW7
      Conserved Domains (1) summary
      pfam01275
      Location:52 → 274
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    3. NM_141066.3 → NP_649323.2  M6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649323.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9A9K0, Q9VP23
      Conserved Domains (1) summary
      pfam01275
      Location:73 → 296
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    4. NM_001300214.1 → NP_001287143.1  M6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9A9K2
      Conserved Domains (1) summary
      pfam01275
      Location:3 → 156
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    5. NM_001275235.1 → NP_001262164.1  M6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGC6
      Conserved Domains (1) summary
      pfam01275
      Location:1 → 225
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    6. NM_168911.2 → NP_730642.1  M6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KI49
      Related
      FBpp0078012
      Conserved Domains (1) summary
      pfam01275
      Location:69 → 291
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9A9K2 H9A9K2
    M9PFW7 M9PFW7
    M9PGC0 M9PGC0
    Q7KI49 Q7KI49
    Q9NGC6 Q9NGC6
    Q9VP23 Q9VP23

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