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    CG6015 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6015provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038927
    Locus tag
    Dmel_CG6015
    See related
    AllianceGenome:FB:FBgn0038927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CDC40; Dmel\CG6015; prp17
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6015 in Genome Data Viewer
    Location:
    94A1-94A1; 3-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22032150..22034286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17857872..17860008, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 42 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitchoune Neighboring gene Fas-associated death domain Neighboring gene small Cajal body-specific RNA : MeU5-G38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes. Yu J, et al. Cell Death Dis, 2021 May 14. PMID 33990549, Free PMC Article
    2. Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes. Zheng Q, et al. Cell Death Discov, 2021 Apr 6. PMID 33824283, Free PMC Article
    3. A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation. Rylee J, et al. G3 (Bethesda), 2022 Nov 4. PMID 36218412, Free PMC Article
    4. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article
    5. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6015-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22032150..22034286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142748.5 → NP_651005.1  uncharacterized protein Dmel_CG6015 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD52
      Related
      FBpp0083581
      Conserved Domains (3) summary
      COG2319
      Location:274 → 576
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:277 → 576
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:289 → 327
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD52 Q9VD52

    Gene LinkOut

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