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Conserved domains on  [gi|21355805|ref|NP_651005|]
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uncharacterized protein Dmel_CG6015 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 277-576 1.20e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.20e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 277 HIHTWSGHNKGISSIRWFPKTaHLLLSGSMDCRVKLWEVYGERrCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLW 356
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 357 DAETGDVVSRFTT-RKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSD 435
Cdd:cd00200  79 DLETGECVRTLTGhTSYVSSVAFSPDG---RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 436 DKSMRIWEwdiPVDMKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRFKmnrKKTFTGHmvSGYACQLDF 513
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC---LGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355805 514 SPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPhEASKVVTAGWDGQIKYWD 576
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 277-576 1.20e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.20e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 277 HIHTWSGHNKGISSIRWFPKTaHLLLSGSMDCRVKLWEVYGERrCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLW 356
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 357 DAETGDVVSRFTT-RKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSD 435
Cdd:cd00200  79 DLETGECVRTLTGhTSYVSSVAFSPDG---RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 436 DKSMRIWEwdiPVDMKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRFKmnrKKTFTGHmvSGYACQLDF 513
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC---LGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355805 514 SPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPhEASKVVTAGWDGQIKYWD 576
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-576 1.16e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 1.16e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 276 AHIHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKL 355
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 356 WDAETGDVVSRFT-TRKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTS 434
Cdd:COG2319 189 WDLATGKLLRTLTgHTGAVRSVAFSPDG---KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 435 DDKSMRIWEWDIPVDMKYIADPTmHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRfkmNRKKTFTGHmvSGYACQLDFS 514
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHS-GGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGH--TGAVRSVAFS 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355805 515 PDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEaSKVVTAGWDGQIKYWD 576
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-357 8.83e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 8.83e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21355805    319 RRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWD 357
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 288-485 1.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  288 ISSIRWFPKTAHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFL-SASYDRYIKLWDAETGDVVSR 366
Cdd:PLN00181 535 LSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  367 FTTRKMPFCVKFHPDNSKQHLFvaGTSDKKIICWDTRSGDI-VQEYDRHLGSVSTITFVDDNrRFVTTSDDKSMRIweWD 445
Cdd:PLN00181 614 IKTKANICCVQFPSESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WD 688

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 21355805  446 IPVDMKYIADPTMHSMPA-------VTLAPNGKWMACQSLDNKIVIF 485
Cdd:PLN00181 689 LSMSISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
319-357 9.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 9.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355805   319 RRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWD 357
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 277-576 1.20e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.20e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 277 HIHTWSGHNKGISSIRWFPKTaHLLLSGSMDCRVKLWEVYGERrCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLW 356
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 357 DAETGDVVSRFTT-RKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSD 435
Cdd:cd00200  79 DLETGECVRTLTGhTSYVSSVAFSPDG---RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 436 DKSMRIWEwdiPVDMKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRFKmnrKKTFTGHmvSGYACQLDF 513
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC---LGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355805 514 SPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPhEASKVVTAGWDGQIKYWD 576
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-576 1.16e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 1.16e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 276 AHIHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKL 355
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 356 WDAETGDVVSRFT-TRKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTS 434
Cdd:COG2319 189 WDLATGKLLRTLTgHTGAVRSVAFSPDG---KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 435 DDKSMRIWEWDIPVDMKYIADPTmHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRfkmNRKKTFTGHmvSGYACQLDFS 514
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHS-GGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGH--TGAVRSVAFS 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355805 515 PDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEaSKVVTAGWDGQIKYWD 576
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
278-536 6.01e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.80  E-value: 6.01e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 278 IHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWD 357
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 358 AETGDVVSRFTT-RKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDD 436
Cdd:COG2319 233 LATGKLLRTLTGhSGSVRSVAFSPDG---RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 437 KSMRIWEWDIPvdmKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRfkmNRKKTFTGHmvSGYACQLDFS 514
Cdd:COG2319 310 GTVRLWDLATG---KLLRTLTGHTGAvrSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGH--TGAVTSVAFS 381

                       250       260
                ....*....|....*....|..
gi 21355805 515 PDMSYLVSGDGDGKCYIWDWKT 536
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
276-576 8.94e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 8.94e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 276 AHIHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWEVYGeRRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKL 355
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 356 WDAETGDVVSRFTTRKMP-FCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTS 434
Cdd:COG2319 147 WDLATGKLLRTLTGHSGAvTSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 435 DDKSMRIWEWDipvDMKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRfkmNRKKTFTGHmvSGYACQLD 512
Cdd:COG2319 224 ADGTVRLWDLA---TGKLLRTLTGHSGSvrSVAFSPDGRLLASGSADGTVRLWDLATG---ELLRTLTGH--SGGVNSVA 295

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355805 513 FSPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEaSKVVTAGWDGQIKYWD 576
Cdd:COG2319 296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
276-576 1.28e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.28e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 276 AHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGerRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKL 355
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 356 WDAETGDVVSRFT-TRKMPFCVKFHPDNskqHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTS 434
Cdd:COG2319 105 WDLATGLLLRTLTgHTGAVRSVAFSPDG---KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 435 DDKSMRIWEWDipvDMKYIADPTMHSMP--AVTLAPNGKWMACQSLDNKIVIFSALNRfkmNRKKTFTGHmvSGYACQLD 512
Cdd:COG2319 182 DDGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGH--SGSVRSVA 253

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355805 513 FSPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPhEASKVVTAGWDGQIKYWD 576
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 275-357 5.81e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 5.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 275 KAHIHTWSGHNKGISSIRWFPKTaHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIK 354
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 21355805 355 LWD 357
Cdd:cd00200 287 IWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-357 8.83e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 8.83e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21355805    319 RRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWD 357
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 288-485 1.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  288 ISSIRWFPKTAHLLLSGSMDCRVKLWEVyGERRCIRTFSGHRQAIKDIAWNNRGTNFL-SASYDRYIKLWDAETGDVVSR 366
Cdd:PLN00181 535 LSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  367 FTTRKMPFCVKFHPDNSKQHLFvaGTSDKKIICWDTRSGDI-VQEYDRHLGSVSTITFVDDNrRFVTTSDDKSMRIweWD 445
Cdd:PLN00181 614 IKTKANICCVQFPSESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WD 688

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 21355805  446 IPVDMKYIADPTMHSMPA-------VTLAPNGKWMACQSLDNKIVIF 485
Cdd:PLN00181 689 LSMSISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
319-357 9.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 9.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355805   319 RRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWD 357
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 277-403 3.52e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  277 HIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVygER-RCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKL 355
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV--ERgKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21355805  356 WDAETGDVVSRFTTR---KMPFCVKFHPDNSKQHLFVAGTSDKKIICWDTR 403
Cdd:PTZ00421 195 IDPRDGTIVSSVEAHasaKSQRCLWAKRKDLIITLGCSKSQQRQIMLWDTR 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 278-314 4.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 21355805    278 IHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWE 314
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 492-533 6.86e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.86e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 21355805    492 KMNRKKTFTGHmvSGYACQLDFSPDMSYLVSGDGDGKCYIWD 533
Cdd:smart00320   1 SGELLKTLKGH--TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
334-447 9.51e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 9.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 334 DIAWNNRGTN-FLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKqhLFVAGTSDKKIIC----WDTRSGDIV 408
Cdd:COG3391 114 GLAVDPDGGRlYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKR--LYVANSGSNTVSVivsvIDTATGKVV 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21355805 409 QEYDRHLGSVStITFVDDNRR-FVT-----TSDDKSMRIWEWDIP 447
Cdd:COG3391 192 ATIPVGGGPVG-VAVSPDGRRlYVAnrgsnTSNGGSNTVSVIDLA 235
WD40 pfam00400
WD domain, G-beta repeat;
278-314 3.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21355805   278 IHTWSGHNKGISSIRWFPkTAHLLLSGSMDCRVKLWE 314
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
335-528 4.78e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 4.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 335 IAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFVAGTSDKKIICWDTRSGDIVQEYDrH 414
Cdd:COG3391  30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-V 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 415 LGSVSTITFVDDNRR-FVTTSDDKsmRIWEWDIPvDMKYIADPTMHSMP-AVTLAPNGKWM-ACQSLDNKI-VIFSALNR 490
Cdd:COG3391 109 GGGPRGLAVDPDGGRlYVADSGNG--RVSVIDTA-TGKVVATIPVGAGPhGIAVDPDGKRLyVANSGSNTVsVIVSVIDT 185

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 21355805 491 FKMNRKKTFTghmVSGYACQLDFSPDMSYL-VSGDGDGK 528
Cdd:COG3391 186 ATGKVVATIP---VGGGPVGVAVSPDGRRLyVANRGSNT 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 4.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21355805    404 SGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWE 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
344-485 6.76e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 6.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 344 FLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNskQHLFVAGTSDKKIICWDTRSGDIVQEYDrhLG-SVSTIT 422
Cdd:COG3391  83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDG--GRLYVADSGNGRVSVIDTATGKVVATIP--VGaGPHGIA 158

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355805 423 FVDDNRR-FVTTSDDKSMR--IWEWDiPVDMKYIADPTMHSMP-AVTLAPNGK--WMACQ------SLDNKIVIF 485
Cdd:COG3391 159 VDPDGKRlYVANSGSNTVSviVSVID-TATGKVVATIPVGGGPvGVAVSPDGRrlYVANRgsntsnGGSNTVSVI 232
PTZ00420 PTZ00420
coronin; Provisional
 283-443 7.26e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 7.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  283 GHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGER---------RCIrtFSGHRQAIKDIAWNNRGTNFL-SASYDRY 352
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  353 IKLWDAETGDVVSRFTTRKMPFCVKFhpdNSKQHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVST-ITFVD----DN 427
Cdd:PTZ00420 150 VNIWDIENEKRAFQINMPKKLSSLKW---NIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTkNIWIDglggDD 226

                        170       180
                 ....*....|....*....|
gi 21355805  428 RRFVTTSDDKS----MRIWE 443
Cdd:PTZ00420 227 NYILSTGFSKNnmreMKLWD 246
WD40 pfam00400
WD domain, G-beta repeat;
493-533 9.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21355805   493 MNRKKTFTGHmvSGYACQLDFSPDMSYLVSGDGDGKCYIWD 533
Cdd:pfam00400   1 GKLLKTLEGH--TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
405-443 8.34e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355805   405 GDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWE 443
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
401-545 1.48e-03

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 41.40  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805 401 DTRSGDIVQEYDRHlGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIADPTMHSMPavTLAPNGKWMACQSLDN 480
Cdd:COG5354 261 RITERSIPVEKDLK-DPVHDFTWEPLSSRFAVISGYMPASVSVFDLRGNLRFYFPEQKRNTI--FFSPHERYILFAGFDN 337

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355805 481 K---IVIFSALNRFKMNRKktftghmVSGYACQL-DFSPDMS-YLVSGDG-----DGKCYIWDWKTTKMYKKWQA 545
Cdd:COG5354 338 LqgnIEIFDPAGRFKVAGA-------FNGLNTSYcDWSPDGQfYDTDTTSeklrvDNSIKLWDVYGAKVFELTNI 405
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
339-405 2.99e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 2.99e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355805 339 NRGTNFLSAsydrYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNskQHLFVA----GTSDK---KIICWDTRSG 405
Cdd:COG3391 170 NSGSNTVSV----IVSVIDTATGKVVATIPVGGGPVGVAVSPDG--RRLYVAnrgsNTSNGgsnTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 536-576 4.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21355805    536 TTKMYKKWQAHDGVCISALWHPHEaSKVVTAGWDGQIKYWD 576
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 327-419 8.74e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355805  327 GHRQAIKDIAWNNRGTNFL-SASYDRYIKLWDAETGDVVSrfttrkmpfCVKFHPD-------NSKQHLFVAGTSDKKII 398
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVE---------VIKCHSDqitslewNLDGSLLCTTSKDKKLN 193

                         90       100
                 ....*....|....*....|.
gi 21355805  399 CWDTRSGDIVQEYDRHLGSVS 419
Cdd:PTZ00421 194 IIDPRDGTIVSSVEAHASAKS 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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