Bcat1 branched chain amino acid transaminase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcat1provided by RGD
Official Full Name: branched chain amino acid transaminase 1provided by RGD
Primary source: RGD:2195
See related: EnsemblRapid:ENSRNOG00000015514 AllianceGenome:RGD:2195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bcatc
Summary: Enables branched-chain-amino-acid transaminase activity and identical protein binding activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Is active in cytoplasm. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1453.7) and Uterus (RPKM 95.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (179695662..179777973, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (177964834..178046573, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (179259305..179340021, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
Title: BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
this metabolic enzyme is expressed throughout the brain and spinal cord, with distinct differences in regional and intracellular patterns of expression.
Title: Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048984 (e-PCR)
- UniSTS:145433

RH138612 (e-PCR)
- UniSTS:220699

RH128559 (e-PCR)
- UniSTS:211867

RH137483 (e-PCR)
- UniSTS:219571

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-valine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables branched-chain-amino-acid transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain-amino-acid transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables branched-chain-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-amino-acid transaminase activity	ISO Inferred from Sequence Orthology more info
enables branched-chain-amino-acid transaminase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branched-chain amino acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: branched-chain-amino-acid aminotransferase, cytosolic

Names: BCAT(c); branched chain amino acid transaminase 1, cytosolic; branched chain aminotransferase 1, cytosolic

NP_001380930.1

EC 2.6.1.42

NP_058949.1

EC 2.6.1.42

XP_008761592.1

EC 2.6.1.42

XP_008761594.1

EC 2.6.1.42

XP_008761595.1

EC 2.6.1.42

XP_063141757.1

EC 2.6.1.42

XP_063141758.1

EC 2.6.1.42

XP_063141759.1

EC 2.6.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394001.2 → NP_001380930.1 branched-chain-amino-acid aminotransferase, cytosolic isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2K7K5, A6IMZ3, Q99JD5

Related

ENSRNOP00000074245.1, ENSRNOT00000080410.3

Conserved Domains (1) summary

PRK13357
Location:52 → 391

PRK13357; branched-chain amino acid aminotransferase; Provisional
NM_017253.4 → NP_058949.1 branched-chain-amino-acid aminotransferase, cytosolic isoform 1

See identical proteins and their annotated locations for NP_058949.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P54690

UniProtKB/TrEMBL

A6IMZ1, A6IMZ3

Related

ENSRNOP00000085607.1, ENSRNOT00000119115.2

Conserved Domains (2) summary

PRK13357
Location:64 → 403

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:105 → 400

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

179695662..179777973 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285688.1 → XP_063141758.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X3

UniProtKB/TrEMBL

A0A0G2K7K5, A6IMZ3, Q99JD5
XM_008763372.3 → XP_008761594.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X3

See identical proteins and their annotated locations for XP_008761594.1

UniProtKB/TrEMBL

A0A0G2K7K5, A6IMZ3, Q99JD5

Conserved Domains (1) summary

PRK13357
Location:52 → 391

PRK13357; branched-chain amino acid aminotransferase; Provisional
XM_063285689.1 → XP_063141759.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X4

UniProtKB/TrEMBL

A0A0G2K7K5, A6IMZ3, Q99JD5

Related

ENSRNOP00000090195.1, ENSRNOT00000117044.2
XM_063285687.1 → XP_063141757.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X1

UniProtKB/TrEMBL

A0A8I6A0J2
XM_008763370.4 → XP_008761592.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X2

UniProtKB/TrEMBL

A0A8I5ZVC5, A6IMZ3

Conserved Domains (2) summary

PRK13357
Location:81 → 420

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:122 → 417

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
XM_008763373.3 → XP_008761595.1 branched-chain-amino-acid aminotransferase, cytosolic isoform X5

See identical proteins and their annotated locations for XP_008761595.1

UniProtKB/TrEMBL

A0A8L2QAQ9, A6IMZ4

Related

ENSRNOP00000021193.6, ENSRNOT00000021193.9

Conserved Domains (2) summary

PRK13357
Location:51 → 390

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:92 → 387

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...