|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
64-403 |
2.35e-138 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 399.52 E-value: 2.35e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 64 KKKPDPSSLVFGASFTDHMLMVEWTSKyGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMK 143
Cdd:PRK13357 14 KRAIDWANLGFGYVFTDHMVVIDYKDG-KWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFRPDANAK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 144 RMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWV-PYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNG 222
Cdd:PRK13357 93 RLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 223 tFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGEEel 301
Cdd:PRK13357 173 -VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFF--ITKDGTV-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 302 aTPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTME 381
Cdd:PRK13357 248 -TPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGE 325
|
330 340
....*....|....*....|..
gi 8392971 382 NGhKLSSRIMAKLTDIQYGRIK 403
Cdd:PRK13357 326 VG-PVTQKLYDELTGIQFGDVE 346
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
105-400 |
8.79e-127 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 366.91 E-value: 8.79e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 105 SIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSAS 184
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 185 LYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPkFVRSWKGGTGDFKMGCNYGSSLLAQCEAAE 264
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGG-EKGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 265 NGCHQVLWLYGKENRITEVGTMNLFLYWINkdgeeELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTA 344
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVKDG-----ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 8392971 345 leenrvKEMFGSGTACVVCPVASILYKGQmlhIPTMENGHKLSSRIMAKLTDIQYG 400
Cdd:cd01557 233 ------DEVFATGTAAVVTPVGEIDYRGK---EPGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
93-410 |
2.56e-102 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 305.91 E-value: 2.56e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 93 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQL 172
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 173 DREWVP-YSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCN 251
Cdd:TIGR01123 81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 252 YGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGeFK 330
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFF--ITGDG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 331 VCERHITMDDLSTALEenRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGhKLSSRIMAKLTDIQYGRIKSE--WTL 408
Cdd:TIGR01123 235 VEERRIDIDELKAFVE--AGEIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEDPygWIV 311
|
..
gi 8392971 409 EL 410
Cdd:TIGR01123 312 EV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
93-402 |
2.30e-72 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 228.15 E-value: 2.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 93 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQ 171
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 172 LDREwvpystsASLYIRPTFIGIEPSLGVKKP-SKALLFVILSPVGSYFSNGTFSPVSLWANPkFVRSWKGGTGDFKmGC 250
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 251 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFK 330
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGV--LVTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8392971 331 VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASIlyKGQmlHIPTMENGhKLSSRIMAKLTDIQYGRI 402
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGR--PIGDGKPG-PVTRRLRELYTDIVRGEA 283
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
119-368 |
2.58e-33 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 124.39 E-value: 2.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 119 LFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLDREWVPYstsaslyIRPT-FIGIEP 196
Cdd:pfam01063 2 VFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVGR-------LRLTvSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 197 SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSwkggtgDFKmGCNYGSSLLAQCEAAENGCHQVLwLYGK 276
Cdd:pfam01063 70 FGLPTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 277 ENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGS 356
Cdd:pfam01063 142 DGNVTEGSTSNVFLV---KGGT--LYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFLT 209
|
250
....*....|..
gi 8392971 357 GTACVVCPVASI 368
Cdd:pfam01063 210 NSLRGVTPVSSI 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
64-403 |
2.35e-138 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 399.52 E-value: 2.35e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 64 KKKPDPSSLVFGASFTDHMLMVEWTSKyGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMK 143
Cdd:PRK13357 14 KRAIDWANLGFGYVFTDHMVVIDYKDG-KWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFRPDANAK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 144 RMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWV-PYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNG 222
Cdd:PRK13357 93 RLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 223 tFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGEEel 301
Cdd:PRK13357 173 -VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFF--ITKDGTV-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 302 aTPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTME 381
Cdd:PRK13357 248 -TPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGE 325
|
330 340
....*....|....*....|..
gi 8392971 382 NGhKLSSRIMAKLTDIQYGRIK 403
Cdd:PRK13357 326 VG-PVTQKLYDELTGIQFGDVE 346
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
105-400 |
8.79e-127 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 366.91 E-value: 8.79e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 105 SIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSAS 184
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 185 LYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPkFVRSWKGGTGDFKMGCNYGSSLLAQCEAAE 264
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGG-EKGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 265 NGCHQVLWLYGKENRITEVGTMNLFLYWINkdgeeELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTA 344
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVKDG-----ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 8392971 345 leenrvKEMFGSGTACVVCPVASILYKGQmlhIPTMENGHKLSSRIMAKLTDIQYG 400
Cdd:cd01557 233 ------DEVFATGTAAVVTPVGEIDYRGK---EPGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
93-410 |
2.56e-102 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 305.91 E-value: 2.56e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 93 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQL 172
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 173 DREWVP-YSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCN 251
Cdd:TIGR01123 81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 252 YGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGeFK 330
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFF--ITGDG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 331 VCERHITMDDLSTALEenRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGhKLSSRIMAKLTDIQYGRIKSE--WTL 408
Cdd:TIGR01123 235 VEERRIDIDELKAFVE--AGEIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEDPygWIV 311
|
..
gi 8392971 409 EL 410
Cdd:TIGR01123 312 EV 313
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
110-394 |
1.76e-75 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 235.19 E-value: 1.76e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 110 ASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLdrewvpySTSASLYIR 188
Cdd:cd00449 1 DRGLHYGDGVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAA-------NNGASLYIR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 189 PTFIGIEPSLGV--KKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSsLLAQCEAAENG 266
Cdd:cd00449 69 PLLTRGVGGLGVapPPSPEPTFVVFASPVGAYAKGG-EKGVRLITSPDRRRAAPGGTGDAKTGGNLNS-VLAKQEAAEAG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 267 CHQVLWLYGkENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAle 346
Cdd:cd00449 147 ADEALLLDD-NGYVTEGSASNVFIV---KDGE--LVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDELYAA-- 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 8392971 347 enrvKEMFGSGTACVVCPVASILYKGQmlhipTMENGHKLSSRIMAKL 394
Cdd:cd00449 218 ----DEVFLTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
93-402 |
2.30e-72 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 228.15 E-value: 2.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 93 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQ 171
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 172 LDREwvpystsASLYIRPTFIGIEPSLGVKKP-SKALLFVILSPVGSYFSNGTFSPVSLWANPkFVRSWKGGTGDFKmGC 250
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 251 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFK 330
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGV--LVTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8392971 331 VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASIlyKGQmlHIPTMENGhKLSSRIMAKLTDIQYGRI 402
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGR--PIGDGKPG-PVTRRLRELYTDIVRGEA 283
|
|
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
43-410 |
3.10e-64 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 211.25 E-value: 3.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 43 SEASTQTFRAKDLiitkadvlkkkpDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEG 122
Cdd:PLN02782 58 SSSYTEVTELADI------------DWDNLGFGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 123 LKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVkK 202
Cdd:PLN02782 126 LKAYRKEDGNILLFRPEENAIRMRNGAERMCMPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGL-A 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 203 PSKALLFVI-LSPVGSYFSNGTfSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-I 280
Cdd:PLN02782 205 PAPEYTFLIyVSPVGNYFKEGV-APINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKyL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 281 TEVGTMNLFlywINKDgeEELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTAC 360
Cdd:PLN02782 284 EEVSSCNIF---IVKD--NVISTPAIKGTILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------DEVFCTGTAV 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 8392971 361 VVCPVASILYKGQmlhipTMENGHK----LSSRIMAKLTDIQYGRIKS--EWTLEL 410
Cdd:PLN02782 352 VVSPVGSITYKGK-----RVSYGEGgfgtVSQQLYTVLTSLQMGLIEDnmNWTVEL 402
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
52-410 |
1.85e-60 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 199.77 E-value: 1.85e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 52 AKDLIITKADVLKKKPDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDN 131
Cdd:PLN03117 5 SSPLPTSKADEKYANVKWEELGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 132 KIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVI 211
Cdd:PLN03117 85 RITLFRPDQNALRMQTGADRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 212 LSPVGSYFSNGtfSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFL 290
Cdd:PLN03117 165 ASPVGNYHKAS--SGLNLKVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLDAATGKnIEELSACNIFI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 291 YWINKdgeeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILY 370
Cdd:PLN03117 243 LKGNI-----VSTPPTSGTILPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVFCTGTAVVVKAVETVTF 310
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 8392971 371 KGQMLHIPTMENGhkLSSRIMAKLTDIQYGRI--KSEWTLEL 410
Cdd:PLN03117 311 HDKKVKYRTGEEA--LSTKLHLILTNIQMGVVedKKGWMVEI 350
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
68-403 |
3.85e-50 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 173.75 E-value: 3.85e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 68 DPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCR 147
Cdd:PLN02259 57 DWDNLGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 148 SAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPV 227
Cdd:PLN02259 137 GAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFKEG-MAAL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 228 SLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYG-KENRITEVGTMNLFLYwinkdGEEELATPPL 306
Cdd:PLN02259 216 NLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSvKKKYLEEASSCNVFVV-----KGRTISTPAT 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 307 DGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILYKGQMLHIPTMEngHKL 386
Cdd:PLN02259 291 NGTILEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFCTGTAVVVAPVGTITYQEKRVEYKTGD--ESV 361
|
330
....*....|....*..
gi 8392971 387 SSRIMAKLTDIQYGRIK 403
Cdd:PLN02259 362 CQKLRSVLVGIQTGLIE 378
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
68-410 |
9.68e-49 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 169.90 E-value: 9.68e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 68 DPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCR 147
Cdd:PLN02883 53 DWDKLGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 148 SAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGTfSPV 227
Cdd:PLN02883 133 GAERMCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKEGT-AAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 228 SLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLYWINKdgeeeLATPPL 306
Cdd:PLN02883 212 NLYVEEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDADTGKnIEEVSAANIFLVKGNI-----IVTPAT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 307 DGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILYKGQMLHIPTMENghKL 386
Cdd:PLN02883 287 SGTILGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTGTAAGVASVGSITFKNTRTEYKVGDG--IV 357
|
330 340
....*....|....*....|....*.
gi 8392971 387 SSRIMAKLTDIQYGRIK--SEWTLEL 410
Cdd:PLN02883 358 TQQLRSILLGIQTGSIQdtKDWVLQI 383
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
119-368 |
2.58e-33 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 124.39 E-value: 2.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 119 LFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLDREWVPYstsaslyIRPT-FIGIEP 196
Cdd:pfam01063 2 VFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVGR-------LRLTvSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 197 SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSwkggtgDFKmGCNYGSSLLAQCEAAENGCHQVLwLYGK 276
Cdd:pfam01063 70 FGLPTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 277 ENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGS 356
Cdd:pfam01063 142 DGNVTEGSTSNVFLV---KGGT--LYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFLT 209
|
250
....*....|..
gi 8392971 357 GTACVVCPVASI 368
Cdd:pfam01063 210 NSLRGVTPVSSI 221
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
100-368 |
1.21e-29 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 116.78 E-value: 1.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 100 PFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIrLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQ---LDr 174
Cdd:PRK06606 17 PWEDAKVHVLTHALHYGTGVFEGIRAYDTPKGPA-IFRLREHTKRLFNSAkiLRMEIP-YSVDELMEAQREVVRknnLK- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 175 ewvpystsaSLYIRP-TFIGIEpSLGVKKPS-KALLFVILSPVGSY-----FSNGTFSPVSLWA----NPKFVRSwkggt 243
Cdd:PRK06606 94 ---------SAYIRPlVFVGDE-GLGVRPHGlPTDVAIAAWPWGAYlgeeaLEKGIRVKVSSWTrhapNSIPTRA----- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 244 gdfKMGCNYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELG 323
Cdd:PRK06606 159 ---KASGNYLNSILAKTEARRNGYDEALLL-DVEGYVSEGSGENIF---IVRDGV--LYTPPLTSSILEGITRDTVITLA 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 8392971 324 EEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:PRK06606 230 KDLG-IEVIERRITRDELYIA------DEVFFTGTAAEVTPIREV 267
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
100-368 |
8.29e-28 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 111.30 E-value: 8.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 100 PFENLSIHPAASVLHYAVELFEGLKAFRGvDNKIRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLdrewvp 178
Cdd:TIGR01122 8 DWEDAKVHVLTHALHYGTGVFEGIRAYDT-DKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRK------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 179 ySTSASLYIRP-TFIGIEpSLGVKKPSKAL--LFVILSPVGSY-----FSNGTFSPVSLW--ANPKFVrswkggTGDFKM 248
Cdd:TIGR01122 81 -NNLRSAYIRPlVFRGDG-DLGLNPRAGYKpdVIIAAWPWGAYlgeeaLEKGIDAKVSSWrrNAPNTI------PTAAKA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 249 GCNYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGe 328
Cdd:TIGR01122 153 GGNYLNSLLAKSEARRHGYDEAILL-DVEGYVAEGSGENIF---IVKDG--VLFTPPVTSSILPGITRDTVITLAKELG- 225
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 8392971 329 FKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:TIGR01122 226 IEVVEQPISREELYTA------DEAFFTGTAAEITPIREV 259
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
98-368 |
1.98e-23 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 98.82 E-value: 1.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 98 IKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDRe 175
Cdd:cd01558 6 YVPREEAKVSVFDRGFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAkeLRIDIP-YTREELKELIRELVAKNE- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 176 wvpySTSASLYIRPTFiGIEP-SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSL-------WANPkfvrswkggtgDFK 247
Cdd:cd01558 79 ----GGEGDVYIQVTR-GVGPrGHDFPKCVKPTVVIITQPLPLPPAELLEKGVRVitvpdirWLRC-----------DIK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 248 MgCNYGSSLLAQCEAAENGCHQVlWLYGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWG 327
Cdd:cd01558 143 S-LNLLNNVLAKQEAKEAGADEA-ILLDADGLVTEGSSSNVF---IVKNGV--LVTPPLDNGILPGITRATVIELAKELG 215
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 8392971 328 eFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:cd01558 216 -IPVEERPFSLEELYTA------DEVFLTSTTAEVMPVVEI 249
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
113-368 |
1.88e-14 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 72.73 E-value: 1.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 113 LHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLdrewvpySTSASLYIRPTFI 192
Cdd:cd01559 4 FAYGDGVFETMRALDG-----RLFLLDAHLARLERSARRLGIPEPDLPRLRAALESLLAA-------NDIDEGRIRLILS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 193 ------GIEPSLGvkkPSKALLFVILSPVGSYFSNGT---FSPVSLWANPKFVRswkggtgdFKMgCNYGSSLLAQCEAA 263
Cdd:cd01559 72 rgpggrGYAPSVC---PGPALYVSVIPLPPAWRQDGVrliTCPVRLGEQPLLAG--------LKH-LNYLENVLAKREAR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 264 ENGCHQVLWLYGkENRITEVGTMNLFlyWInKDGEeeLATPPLDGVILPGVTRQSILELGEEWGEFKVcERHITMDDLST 343
Cdd:cd01559 140 DRGADEALFLDT-DGRVIEGTASNLF--FV-KDGE--LVTPSLDRGGLAGITRQRVIELAAAKGYAVD-ERPLRLEDLLA 212
|
250 260
....*....|....*....|....*
gi 8392971 344 AleenrvKEMFGSGTACVVCPVASI 368
Cdd:cd01559 213 A------DEAFLTNSLLGVAPVTAI 231
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
120-368 |
9.67e-14 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 71.06 E-value: 9.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 120 FEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDRewvpySTSAslYIRPTF------ 191
Cdd:PRK08320 33 FEGIRAYNG-----RVFRLKEHIDRLYDSAkaIMLEIP-LSKEEMTEIVLETLRKNN-----LRDA--YIRLVVsrgvgd 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 192 IGIEPslgvKKPSKALLFVILSPVGSY----FSNG----TFS-----PVSLwaNPKfVRSwkggtgdfkmgCNYGSSLLA 258
Cdd:PRK08320 100 LGLDP----RKCPKPTVVCIAEPIGLYpgelYEKGlkviTVStrrnrPDAL--SPQ-VKS-----------LNYLNNILA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 259 QCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITM 338
Cdd:PRK08320 162 KIEANLAGVDEAIML-NDEGYVAEGTGDNIFIV---KNGK--LITPPTYAGALEGITRNAVIEIAKELG-IPVREELFTL 234
|
250 260 270
....*....|....*....|....*....|
gi 8392971 339 DDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:PRK08320 235 HDLYTA------DEVFLTGTAAEVIPVVKV 258
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
120-368 |
5.31e-13 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 68.83 E-value: 5.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 120 FEGLKAFRGVdnkirlfRPDLNM--KRMCRSAVRTTL-PEFDKEELLQCVLQLIQldrewvPYSTSASLYIRPTFIGIEP 196
Cdd:PRK13356 37 FDGARAFEGV-------TPDLDLhcARVNRSAEALGLkPTVSAEEIEALAREGLK------RFDPDTALYIRPMYWAEDG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 197 SLGVKKPSK-----AL-LFVILSPVGSYFSnGTFSPvslwanpkFVRSW-KGGTGDFKMGCNYGSSLLAQCEAAENGCHQ 269
Cdd:PRK13356 104 FASGVAPDPestrfALcLEEAPMPEPTGFS-LTLSP--------FRRPTlEMAPTDAKAGCLYPNNARALREARSRGFDN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 270 VLWLYGKENrITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenr 349
Cdd:PRK13356 175 ALVLDMLGN-VAETATSNVF---MVKDGV--VFTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA----- 242
|
250
....*....|....*....
gi 8392971 350 vKEMFGSGTACVVCPVASI 368
Cdd:PRK13356 243 -DEVFSTGNYSKVVPVTRF 260
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
262-368 |
8.59e-09 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 56.14 E-value: 8.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 262 AAEN-GCHQVLWL-YgkENRITEVGTMNLFLYwinKDGEeeLATPPLDgVILPGVTRQSILELGEEWGeFKVCERHITMD 339
Cdd:PRK07544 171 AAEAkGYADALMLdY--RGYVAEATGANIFFV---KDGV--IHTPTPD-CFLDGITRQTVIELAKRRG-IEVVERHIMPE 241
|
90 100
....*....|....*....|....*....
gi 8392971 340 DLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:PRK07544 242 ELAGF------SECFLTGTAAEVTPVSEI 264
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
115-368 |
3.58e-08 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 54.57 E-value: 3.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 115 YAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDrewvpysTSASLYIR---- 188
Cdd:PRK12479 29 YGDGVFEGIRSYGG-----NVFCLKEHVKRLYESAksILLTIP-LTVDEMEEAVLQTLQKN-------EYADAYIRlivs 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 189 --PTFIGIEPSlGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWA--------NPKfVRSwkggtgdfkmgCNYGSSLLA 258
Cdd:PRK12479 96 rgKGDLGLDPR-SCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASrrntpdalDPR-IKS-----------MNYLNNVLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 259 QCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITM 338
Cdd:PRK12479 163 KIEAAQAGVLEALML-NQQGYVCEGSGDNVF---VVKDGK--VLTPPSYLGALEGITRNSVIELCERLS-IPCEERPFTR 235
|
250 260 270
....*....|....*....|....*....|
gi 8392971 339 DDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:PRK12479 236 HDVYVA------DEVFLTGTAAELIPVVKV 259
|
|
| PLN02845 |
PLN02845 |
Branched-chain-amino-acid aminotransferase-like protein |
251-367 |
3.44e-06 |
|
Branched-chain-amino-acid aminotransferase-like protein
Pssm-ID: 215454 [Multi-domain] Cd Length: 336 Bit Score: 48.47 E-value: 3.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 251 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNL-FLywiNKDGeeELATPPLDGvILPGVTRQSILELGEEWGEF 329
Cdd:PLN02845 188 NYLPNALSQMEAEERGAFAGIWL-DEEGFVAEGPNMNVaFL---TNDG--ELVLPPFDK-ILSGCTARRVLELAPRLVSP 260
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 8392971 330 K----VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVAS 367
Cdd:PLN02845 261 GdlrgVKQRKISVEEAKAA------DEMMLIGSGVPVLPIVS 296
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
257-368 |
6.46e-06 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 47.62 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392971 257 LAQCEAAENGCHQVlWLYGkENRITEVGTMNLFLywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHI 336
Cdd:PRK06680 158 LAKQAAKEAGAQEA-WMVD-DGFVTEGASSNAWI--VTKDGK--LVTRPADNFILPGITRHTLIDLAKELG-LEVEERPF 230
|
90 100 110
....*....|....*....|....*....|..
gi 8392971 337 TMDDLSTAleenrvKEMFGSGTACVVCPVASI 368
Cdd:PRK06680 231 TLQEAYAA------REAFITAASSFVFPVVQI 256
|
|
| PRK07546 |
PRK07546 |
hypothetical protein; Provisional |
280-344 |
1.26e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 169002 [Multi-domain] Cd Length: 209 Bit Score: 43.04 E-value: 1.26e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8392971 280 ITEVGTMNLFLywinKDGEEELATPPLDGVILPGVTRQSILELGeewgefKVCERHITMDDLSTA 344
Cdd:PRK07546 137 VCEGTITNVFL----DRGGGMLTTPPLSCGLLPGVLRAELLDAG------RAREAVLTVDDLKSA 191
|
|
| |
