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    Mcm2 Minichromosome maintenance 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40973, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mcm2provided by FlyBase
    Official Full Name
    Minichromosome maintenance 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014861
    Locus tag
    Dmel_CG7538
    See related
    AllianceGenome:FB:FBgn0014861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7538; dMcm2; dMCM2; Dmel\CG7538; DmeMCM2; DmMcm2; DmMCM2; l(3)rL074; mcm2; McM2; MCM2; mcm2-7; Mcm2-7; MCM2-7; MCM2_DROME; PCR3
    Summary
    Contributes to 3'-5' DNA helicase activity. Involved in chromosome condensation. Part of CMG complex and MCM complex. Is expressed in several structures, including antennal primordium; anterior endoderm; ganglia; mesoderm; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Mcm2 in Genome Data Viewer
    Location:
    84F6-84F6; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8264970..8267924)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4090692..4093646)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mind the gap Neighboring gene pseudo Neighboring gene Replication protein A1 Neighboring gene uncharacterized protein Neighboring gene atonal

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity  
    contributes_to 3'-5' DNA helicase activity PubMed 
    enables ATP binding  
    enables DNA binding  
    enables single-stranded DNA binding  
    contributes_to single-stranded DNA helicase activity  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in DNA replication  
    involved_in DNA replication PubMed 
    involved_in DNA replication initiation  
    involved_in DNA unwinding involved in DNA replication  
    involved_in chromosome condensation PubMed 
    involved_in double-strand break repair via break-induced replication  
    involved_in mitotic DNA replication initiation  
    Component Evidence Code Pubs
    part_of CMG complex PubMed 
    part_of MCM complex  
    part_of MCM complex PubMed 
    part_of MCM complex  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    minichromosome maintenance 2
    Names
    CG7538-PA
    Mcm2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8264970..8267924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057773.4 → NP_477121.1  minichromosome maintenance 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477121.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49735, Q9VHU2
      Related
      FBpp0081317
      Conserved Domains (3) summary
      smart00350
      Location:276 → 780
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:59 → 166
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:182 → 271
      MCM_N; MCM N-terminal domain
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