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Psf2 Partner of Sld Five 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33641, updated on 9-Dec-2024

Summary

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Official Symbol
Psf2provided by FlyBase
Official Full Name
Partner of Sld Five 2provided by FlyBase
Primary source
FLYBASE:FBgn0261976
Locus tag
Dmel_CG18013
See related
AllianceGenome:FB:FBgn0261976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18013; Dmel\CG18013; l(2)SH0805; l(2)SH2 0805; PSF2; P{lacW}l(2)SH0805[SH0805]
Summary
Involved in chromosome condensation. Part of CMG complex and GINS complex. Is expressed in organism. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Psf2 in Genome Data Viewer
Location:
24E4-24E4; 2-12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4386182..4387356, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4386182..4387356, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 53 Neighboring gene Trehalose-6-phosphate synthase 1 Neighboring gene uncharacterized protein Neighboring gene lethal (2) k05819

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Psf2 has a role in chromosome condensation. Chmielewski JP, et al. Chromosoma, 2012 Dec. PMID 22993141, Free PMC Article
  2. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
  3. Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. Gosnell JA, et al. BMC Mol Biol, 2011 Apr 6. PMID 21470422, Free PMC Article
  4. DNA replication machinery contributes to development of eye in Drosophila. Kohzaki H, et al. Front Biosci (Landmark Ed), 2018 Jan 1. PMID 28930558
  5. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IC
Inferred by Curator
more info
 PubMed 
involved_in DNA strand elongation involved in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
partner of Sld five 2
Names
CG18013-PB
CG18013-PC
Psf2-PB
Psf2-PC
lethal (2) SH0805

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4386182..4387356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273093.1 → NP_001260022.1  partner of Sld five 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PB28, Q8SYY9, Q9VQY9
    Conserved Domains (2) summary
    cd11712
    Location:55 → 174
    GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
    cd21694
    Location:2 → 63
    GINS_B_Psf2; beta-strand (B) domain of GINS complex protein Psf2

  2. NM_134982.3 → NP_608826.4  partner of Sld five 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608826.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PB28, Q8SYY9, Q9VQY9
    Conserved Domains (2) summary
    cd11712
    Location:55 → 174
    GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
    cd21694
    Location:2 → 63
    GINS_B_Psf2; beta-strand (B) domain of GINS complex protein Psf2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQY9.1 Q9VQY9

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