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    RGS5 regulator of G protein signaling 5 [ Homo sapiens (human) ]

    Gene ID: 8490, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RGS5provided by HGNC
    Official Full Name
    regulator of G protein signaling 5provided by HGNC
    Primary source
    HGNC:HGNC:10001
    See related
    Ensembl:ENSG00000143248 MIM:603276; AllianceGenome:HGNC:10001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]
    Expression
    Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS5 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163142299..163321735, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162487178..162666666, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163112089..163291525, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene regulator of G protein signaling 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:163101622-163102196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_592 Neighboring gene RGS5 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163172770-163173435 Neighboring gene uncharacterized LOC127814295 Neighboring gene TRNT1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2014 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163369660-163370204 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:163384530-163384653 Neighboring gene eukaryotic translation initiation factor 3 subunit J pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. Enström A, et al. Biol Open, 2022 Oct 15. PMID 36111549, Free PMC Article
    2. RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells. Jin Y, et al. J Biol Chem, 2009 Aug 28. PMID 19564336, Free PMC Article
    3. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese. Xiao B, et al. Clin Chem Lab Med, 2009. PMID 19863299
    4. Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. Adams LD, et al. Arterioscler Thromb Vasc Biol, 2006 Feb. PMID 16293795
    5. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. Liang Y, et al. FEBS J, 2005 Feb. PMID 15670159

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
      Title: Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
    2. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
      Title: RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
    3. Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
      Title: Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
    4. Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
      Title: Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
    5. RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
      Title: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
    6. RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
      Title: RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
    7. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
      Title: Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
    8. Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
      Title: Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
    9. Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
      Title: Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
    10. Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
      Title: Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Essential hypertension, genetic
    MedGen: CN305331 OMIM: 145500 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 5
    Names
    regulator of G-protein signalling 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027731.2 RefSeqGene

      Range
      123876..184493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195303.3 → NP_001182232.1  regulator of G-protein signaling 5 isoform 2

      See identical proteins and their annotated locations for NP_001182232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AJ891044, AL157502, AL583850, BX537427, DA699380
      Consensus CDS
      CCDS55652.1
      UniProtKB/Swiss-Prot
      O15539
      Related
      ENSP00000432313.1, ENST00000527988.1
      Conserved Domains (1) summary
      cl02565
      Location:1 → 70
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001254748.2 → NP_001241677.1  regulator of G-protein signaling 5 isoform 2

      See identical proteins and their annotated locations for NP_001241677.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AL157502, AL583850, BP292867, BX537427
      Consensus CDS
      CCDS55652.1
      UniProtKB/Swiss-Prot
      O15539
      Related
      ENSP00000480891.1, ENST00000618415.4
      Conserved Domains (1) summary
      cl02565
      Location:1 → 70
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_001254749.2 → NP_001241678.1  regulator of G-protein signaling 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AL157502, AL583850, BU172751, BX537427, DA699380
      Consensus CDS
      CCDS58041.1
      UniProtKB/TrEMBL
      B2RD05
      Related
      ENSP00000433001.1, ENST00000530507.5
      Conserved Domains (1) summary
      cd08717
      Location:65 → 182
      RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

    4. NM_001414472.1 → NP_001401401.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05

    5. NM_001414473.1 → NP_001401402.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05

    6. NM_001414474.1 → NP_001401403.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05

    7. NM_001414475.1 → NP_001401404.1  regulator of G-protein signaling 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL451063, AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05

    8. NM_001414476.1 → NP_001401405.1  regulator of G-protein signaling 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435
      UniProtKB/TrEMBL
      B2RD05

    9. NM_001414477.1 → NP_001401406.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435

    10. NM_001414478.1 → NP_001401407.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435

    11. NM_001414479.1 → NP_001401408.1  regulator of G-protein signaling 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL499616, AL583850, AL592435

    12. NM_003617.4 → NP_003608.1  regulator of G-protein signaling 5 isoform 1

      See identical proteins and their annotated locations for NP_003608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions.
      Source sequence(s)
      AL451063, AL583850, BC030059
      Consensus CDS
      CCDS1244.1
      UniProtKB/Swiss-Prot
      E9PMP5, O15539, Q53XA9, Q599J0
      UniProtKB/TrEMBL
      B2RD05
      Related
      ENSP00000319308.5, ENST00000313961.10
      Conserved Domains (1) summary
      cd08717
      Location:65 → 178
      RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      163142299..163321735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      162487178..162666666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025226.1: Suppressed sequence

      Description
      NM_025226.1: This RefSeq was permanently suppressed because it is UTR sequence and contains the wrong CDS.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15539.1 GenPept UniProtKB/Swiss-Prot:O15539

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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