U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Essential hypertension, genetic(EHT)

MedGen UID:
987958
Concept ID:
CN305331
Disease or Syndrome
Synonym: EHT
 
Genes (locations): ADD1 (4p16.3); AGT (1q42.2); AGTR1 (3q24); ATP1B1 (1q24.2); CYP3A5 (7q22.1); ECE1 (1p36.12); GNB3 (12p13.31); NOS3 (7q36.1); PTGIS (20q13.13); RGS5 (1q23.3)
 
Monarch Initiative: MONDO:0007781
OMIM®: 145500

Definition

An instance of essential hypertension that is caused by a modification of the individual's genome. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Solinas S, Boucly A, Beurnier A, Kularatne M, Grynblat J, Eyries M, Dorfmüller P, Sitbon O, Humbert M, Montani D
Expert Rev Respir Med 2023 Jul-Dec;17(8):635-649. Epub 2023 Aug 21 doi: 10.1080/17476348.2023.2247989. PMID: 37578057
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
Gurnani M, Birken C, Hamilton J
Pediatr Clin North Am 2015 Aug;62(4):821-40. Epub 2015 May 23 doi: 10.1016/j.pcl.2015.04.001. PMID: 26210619

Recent clinical studies

Etiology

Wu DF, Yin RX, Deng JL
Eur J Prev Cardiol 2024 Jul 23;31(9):1092-1103. doi: 10.1093/eurjpc/zwae022. PMID: 38236144
Falkner B, Gidding SS, Baker-Smith CM, Brady TM, Flynn JT, Malle LM, South AM, Tran AH, Urbina EM; American Heart Association Council on Hypertension; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Cardiovascular and Stroke Nursing
Hypertension 2023 Jun;80(6):e101-e111. Epub 2023 Mar 30 doi: 10.1161/HYP.0000000000000228. PMID: 36994715
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J
Microbiome 2017 Feb 1;5(1):14. doi: 10.1186/s40168-016-0222-x. PMID: 28143587Free PMC Article
Wise IA, Charchar FJ
Int J Mol Sci 2016 Mar 25;17(4):451. doi: 10.3390/ijms17040451. PMID: 27023534Free PMC Article
Chen S, Sun Y, Agrawal DK
J Am Soc Hypertens 2015 Nov;9(11):885-901. Epub 2015 Aug 21 doi: 10.1016/j.jash.2015.08.009. PMID: 26419755Free PMC Article

Diagnosis

Wu DF, Yin RX, Deng JL
Eur J Prev Cardiol 2024 Jul 23;31(9):1092-1103. doi: 10.1093/eurjpc/zwae022. PMID: 38236144
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Falkner B, Gidding SS, Baker-Smith CM, Brady TM, Flynn JT, Malle LM, South AM, Tran AH, Urbina EM; American Heart Association Council on Hypertension; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Cardiovascular and Stroke Nursing
Hypertension 2023 Jun;80(6):e101-e111. Epub 2023 Mar 30 doi: 10.1161/HYP.0000000000000228. PMID: 36994715
Huber MJ, Chen QH, Shan Z
Cell Mol Neurobiol 2018 Mar;38(2):385-391. Epub 2017 Mar 27 doi: 10.1007/s10571-017-0487-z. PMID: 28349223Free PMC Article
Chen S, Sun Y, Agrawal DK
J Am Soc Hypertens 2015 Nov;9(11):885-901. Epub 2015 Aug 21 doi: 10.1016/j.jash.2015.08.009. PMID: 26419755Free PMC Article

Therapy

Yang J, Zhou J, Yang J, Lou H, Zhao B, Chi J, Tang W
Sci Rep 2024 Jan 10;14(1):968. doi: 10.1038/s41598-023-50351-6. PMID: 38200066Free PMC Article
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E
Hypertension 2022 Sep;79(9):1962-1970. Epub 2022 Jul 25 doi: 10.1161/HYPERTENSIONAHA.122.19120. PMID: 35876003
Chen S, Sun Y, Agrawal DK
J Am Soc Hypertens 2015 Nov;9(11):885-901. Epub 2015 Aug 21 doi: 10.1016/j.jash.2015.08.009. PMID: 26419755Free PMC Article
Moncada S
J Hypertens Suppl 1994 Dec;12(10):S35-9. PMID: 7539493

Prognosis

Wang N, Yu Y, Sun Y, Zhang H, Wang Y, Chen C, Tan X, Wang B, Lu Y
Eur Heart J 2023 Dec 14;44(47):4982-4993. doi: 10.1093/eurheartj/ehad615. PMID: 37723974Free PMC Article
Xie J, Huang H, Liu Z, Li Y, Yu C, Xu L, Xu C
Hepatology 2023 Mar 1;77(3):949-964. Epub 2023 Feb 17 doi: 10.1002/hep.32728. PMID: 35971878
Chen S, Sun Y, Agrawal DK
J Am Soc Hypertens 2015 Nov;9(11):885-901. Epub 2015 Aug 21 doi: 10.1016/j.jash.2015.08.009. PMID: 26419755Free PMC Article
Smajlović D
Vasc Health Risk Manag 2015;11:157-64. Epub 2015 Feb 24 doi: 10.2147/VHRM.S53203. PMID: 25750539Free PMC Article
Benaiges D, Goday A, Pedro-Botet J, Más A, Chillarón JJ, Flores-Le Roux JA
Minerva Endocrinol 2015 Jun;40(2):119-28. Epub 2015 Feb 10 PMID: 25665592

Clinical prediction guides

Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E
Hypertension 2022 Sep;79(9):1962-1970. Epub 2022 Jul 25 doi: 10.1161/HYPERTENSIONAHA.122.19120. PMID: 35876003
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Loscalzo J
Circ Res 2019 Mar 29;124(7):987-989. doi: 10.1161/CIRCRESAHA.119.314403. PMID: 30920923Free PMC Article
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J
Microbiome 2017 Feb 1;5(1):14. doi: 10.1186/s40168-016-0222-x. PMID: 28143587Free PMC Article

Recent systematic reviews

Elsaid N, Saied A, Kandil H, Soliman A, Taher F, Hadi M, Giridharan G, Jennings R, Casanova M, Keynton R, El-Baz A
Front Biosci (Landmark Ed) 2021 Dec 30;26(12):1643-1652. doi: 10.52586/5057. PMID: 34994178
Liu M, Yi J, Tang W
J Renin Angiotensin Aldosterone Syst 2021 Jan-Dec;22(1):1470320321995074. doi: 10.1177/1470320321995074. PMID: 33726555Free PMC Article
Yako YY, Balti EV, Matsha TE, Dzudie A, Kruger D, Sobngwi E, Agyemang C, Kengne AP
J Clin Hypertens (Greenwich) 2018 Mar;20(3):485-495. Epub 2018 Mar 9 doi: 10.1111/jch.13225. PMID: 29520984Free PMC Article
Reiter LM, Christensen DL, Gjesing AP
J Hum Hypertens 2016 Aug;30(8):467-78. Epub 2015 Nov 26 doi: 10.1038/jhh.2015.114. PMID: 26607294
Xi B, Chen M, Chandak GR, Shen Y, Yan L, He J, Mou SH
PLoS One 2013;8(3):e59584. Epub 2013 Mar 18 doi: 10.1371/journal.pone.0059584. PMID: 23527223Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...