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    ant-1.2 ADP/ATP translocase [ Caenorhabditis elegans ]

    Gene ID: 189112, updated on 9-Dec-2024

    Summary

    Official Symbol
    ant-1.2
    Official Full Name
    ADP/ATP translocase
    Primary source
    WormBase:WBGene00007057
    Locus tag
    CELE_W02D3.6
    See related
    AllianceGenome:WB:WBGene00007057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in mitochondrion. Is expressed in body wall musculature; head neurons; intestine; pharynx; and seam cell. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ant-1.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003279.8 (6730057..6730959, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Mechanosensory abnormality protein 6 Neighboring gene Fatty acid-binding protein homolog 6 Neighboring gene Fatty acid-binding protein homolog 5 Neighboring gene PIN domain-containing protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    ADP/ATP translocase
    NP_491927.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6730057..6730959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059526.3NP_491927.1  ADP/ATP translocase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4YEQ8, O01813
      Conserved Domains (2) summary
      PTZ00169
      Location:12300
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:11105
      Mito_carr; Mitochondrial carrier protein
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