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ymel-1 ATP-dependent zinc metalloprotease YME1 homolog [ Caenorhabditis elegans ]

Gene ID: 176460, updated on 9-Dec-2024

Summary

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Official Symbol
ymel-1
Official Full Name
ATP-dependent zinc metalloprotease YME1 homolog
Primary source
WormBase:WBGene00010842
Locus tag
CELE_M03C11.5
See related
AllianceGenome:WB:WBGene00010842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ymel-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (10416139..10421757)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase chl-1 Neighboring gene PH domain-containing protein Neighboring gene Histone acetyltransferase type B catalytic subunit Neighboring gene BBS2_C domain-containing protein Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. van Ham TJ, et al. PLoS Genet, 2008 Mar 21. PMID 18369446, Free PMC Article
  2. Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans. Pandey T, et al. Exp Gerontol, 2019 Jun. PMID 30825547
  3. Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1. Sharma S, et al. Mol Neurobiol, 2021 Jan. PMID 32894501
  4. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Monaghan RM, et al. Nat Cell Biol, 2015 Jun. PMID 25961505, Free PMC Article
  5. NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Romani M, et al. Cell Rep, 2021 Jan 19. PMID 33472069, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of m-AAA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent zinc metalloprotease YME1 homolog
NP_001366715.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10416139..10421757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379892.2 → NP_001366715.1  ATP-dependent zinc metalloprotease YME1 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54813
    Conserved Domains (1) summary
    TIGR01241
    Location:195 → 685
    FtsH_fam; ATP-dependent metalloprotease FtsH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54813.2

Gene LinkOut

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