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    ppfr-2 Protein Phosphatase Four Regulatory subunit [ Caenorhabditis elegans ]

    Gene ID: 172381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppfr-2
    Official Full Name
    Protein Phosphatase Four Regulatory subunit
    Primary source
    WormBase:WBGene00017064
    Locus tag
    CELE_D2092.2
    See related
    AllianceGenome:WB:WBGene00017064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ppfr-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (6625066..6626788, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Translation initiation factor IF-2 Neighboring gene AcetylCholine Receptor Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene C2 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. Rivard RS, et al. PLoS One, 2020. PMID 33315870, Free PMC Article
    2. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
    3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein Phosphatase Four Regulatory subunit
    NP_491907.1
    • Product from WormBase gene class ppfr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6625066..6626788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059506.7 → NP_491907.1  Protein Phosphatase Four Regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91198
      Conserved Domains (1) summary
      pfam09184
      Location:110 → 286
      PPP4R2; PPP4R2
    Nucleotide Protein
    Heading Accession and Version

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