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Conserved domains on  [gi|17506405|ref|NP_491907|]
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Protein Phosphatase Four Regulatory subunit [Caenorhabditis elegans]

Protein Classification

serine/threonine-protein phosphatase 4 regulatory subunit 2( domain architecture ID 10293)

serine/threonine-protein phosphatase 4 regulatory subunit 2 (PP4R2) is a regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process

Gene Ontology:  GO:0030289|GO:0019888

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP4R2 super family cl07707
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 127-300 3.65e-31

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


The actual alignment was detected with superfamily member pfam09184:

Pssm-ID: 462710  Cd Length: 256  Bit Score: 119.06  E-value: 3.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   127 EKIAESPVKEKL-SILGHkvnLIKTTPV-VFSTEESMEFVLSKAKSFDGFPFTWQRLCELLIEPMRHYNTIDKFLRAVDK 204
Cdd:pfam09184  34 WSSFKPLFREKLeNVIDH---FTETIPEeIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   205 VINVVTTINENGGRSFGDWDlpnsQQFHLENTFFGVVDEvemmelekvkhdfqsssspseePLDMSQKSMPAPRVSTASP 284
Cdd:pfam09184 111 NCLVVSTWDPGSERSESEKD----NGDSSDNRINGVMPD----------------------PLDVSLVSIPWSDETNGLP 164

                         170
                  ....*....|....*.
gi 17506405   285 DPPSFVLPTARSPINT 300
Cdd:pfam09184 165 LSPFIKEIDSIMSVNF 180
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 127-300 3.65e-31

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 119.06  E-value: 3.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   127 EKIAESPVKEKL-SILGHkvnLIKTTPV-VFSTEESMEFVLSKAKSFDGFPFTWQRLCELLIEPMRHYNTIDKFLRAVDK 204
Cdd:pfam09184  34 WSSFKPLFREKLeNVIDH---FTETIPEeIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   205 VINVVTTINENGGRSFGDWDlpnsQQFHLENTFFGVVDEvemmelekvkhdfqsssspseePLDMSQKSMPAPRVSTASP 284
Cdd:pfam09184 111 NCLVVSTWDPGSERSESEKD----NGDSSDNRINGVMPD----------------------PLDVSLVSIPWSDETNGLP 164

                         170
                  ....*....|....*.
gi 17506405   285 DPPSFVLPTARSPINT 300
Cdd:pfam09184 165 LSPFIKEIDSIMSVNF 180
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 127-300 3.65e-31

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 119.06  E-value: 3.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   127 EKIAESPVKEKL-SILGHkvnLIKTTPV-VFSTEESMEFVLSKAKSFDGFPFTWQRLCELLIEPMRHYNTIDKFLRAVDK 204
Cdd:pfam09184  34 WSSFKPLFREKLeNVIDH---FTETIPEeIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506405   205 VINVVTTINENGGRSFGDWDlpnsQQFHLENTFFGVVDEvemmelekvkhdfqsssspseePLDMSQKSMPAPRVSTASP 284
Cdd:pfam09184 111 NCLVVSTWDPGSERSESEKD----NGDSSDNRINGVMPD----------------------PLDVSLVSIPWSDETNGLP 164

                         170
                  ....*....|....*.
gi 17506405   285 DPPSFVLPTARSPINT 300
Cdd:pfam09184 165 LSPFIKEIDSIMSVNF 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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