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    lit-1 Serine/threonine kinase NLK [ Caenorhabditis elegans ]

    Gene ID: 176808, updated on 9-Dec-2024

    Summary

    Official Symbol
    lit-1
    Official Full Name
    Serine/threonine kinase NLK
    Primary source
    WormBase:WBGene00003048
    Locus tag
    CELE_W06F12.1
    See related
    AllianceGenome:WB:WBGene00003048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell fate specification; and polarity specification of proximal/distal axis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Is expressed in several structures, including E; amphid sheath cell; hermaphrodite gonad; pharynx; and tail hypodermis. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See lit-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (13701993..13724404)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein dyf-2 Neighboring gene Systemic RNA interference defective protein 2 Neighboring gene Cullin-2 Neighboring gene Peptidyl-prolyl cis-trans isomerase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc finger protein Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables MAP kinase activity  
    enables beta-catenin binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in Wnt signaling pathway  
    involved_in Wnt signaling pathway PubMed 
    involved_in anatomical structure morphogenesis PubMed 
    involved_in asymmetric cell division PubMed 
    involved_in asymmetric protein localization involved in cell fate determination PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in endoderm development PubMed 
    involved_in endodermal cell fate specification PubMed 
    involved_in intracellular signal transduction  
    involved_in muscle cell fate specification PubMed 
    involved_in polarity specification of proximal/distal axis PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis PubMed 
    involved_in protein phosphorylation  
    Component Evidence Code Pubs
    located_in cell cortex PubMed 
    located_in cell cortex  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of serine/threonine protein kinase complex PubMed 

    General protein information

    Preferred Names
    Serine/threonine kinase NLK
    NP_001022805.1
    • Confirmed by transcript evidence
    NP_001022806.1
    • Confirmed by transcript evidence
    NP_001022807.1
    • Confirmed by transcript evidence
    NP_001022808.1
    • Confirmed by transcript evidence
    NP_001367102.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13701993..13724404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027637.6 → NP_001022808.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:206 → 583
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:211 → 498
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    2. NM_001027634.3 → NP_001022805.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62395, Q69YW9, Q8WQB7, Q9U343, Q9U9Y8, Q9UA07, Q9Y198
      Conserved Domains (2) summary
      cd07853
      Location:239 → 616
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:244 → 531
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    3. NM_001027635.6 → NP_001022806.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:67 → 444
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:72 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    4. NM_001379989.1 → NP_001367102.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07853
      Location:59 → 436
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    5. NM_001027636.4 → NP_001022807.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:42 → 419
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:47 → 334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
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