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D1037.1 Protein SON [ Caenorhabditis elegans ]

Gene ID: 171936, updated on 9-Dec-2024

Summary

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Official Symbol
D1037.1
Official Full Name
Protein SON
Primary source
WormBase:WBGene00017025
Locus tag
CELE_D1037.1
See related
AllianceGenome:WB:WBGene00017025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Human ortholog(s) of this gene implicated in ZTTK syndrome and congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to human SON (SON DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See D1037.1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (3684781..3690347)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ferritin Neighboring gene Ras-related protein Rab-8A Neighboring gene phospholipase A2 Neighboring gene DNA mismatch repair proteins mutS family domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein SON
NP_491200.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3684781..3690347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058799.6 → NP_491200.1  Protein SON [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYS1
    Conserved Domains (2) summary
    cd00048
    Location:706 → 773
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam01585
    Location:637 → 681
    G-patch; G-patch domain
Nucleotide Protein
Heading Accession and Version

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