Nsdhl NAD(P) dependent steroid dehydrogenase-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nsdhlprovided by RGD
Official Full Name: NAD(P) dependent steroid dehydrogenase-likeprovided by RGD
Primary source: RGD:1359337
See related: EnsemblRapid:ENSRNOG00000057814 AllianceGenome:RGD:1359337
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in cholesterol metabolic process. Predicted to act upstream of or within hair follicle development; labyrinthine layer blood vessel development; and smoothened signaling pathway. Predicted to be located in lipid droplet. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1015.9), Kidney (RPKM 76.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (155817301..155848224)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (150775034..150807161)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (152933118..152964399)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

NP_001009399.1

EC 1.1.1.170

XP_017457511.1

EC 1.1.1.170

XP_038955611.1

EC 1.1.1.170

XP_063136039.1

EC 1.1.1.170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009399.1 → NP_001009399.1 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

See identical proteins and their annotated locations for NP_001009399.1

Status: PROVISIONAL

Source sequence(s)

BC087626

UniProtKB/Swiss-Prot

Q5PPL3

UniProtKB/TrEMBL

A6KSY6

Related

ENSRNOP00000069662.1, ENSRNOT00000091154.3

Conserved Domains (1) summary

cl21454
Location:29 → 355

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

155817301..155848224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602022.3 → XP_017457511.1 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X2
XM_039099683.2 → XP_038955611.1 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X3

Conserved Domains (1) summary

cl21454
Location:1 → 201

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_063279969.1 → XP_063136039.1 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X1

UniProtKB/Swiss-Prot

Q5PPL3

UniProtKB/TrEMBL

A6KSY6