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    rec8 meiotic cohesin complex kleisin subunit Rec8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540458, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rec8
    Official Full Name
    meiotic cohesin complex kleisin subunit Rec8
    Primary source
    PomBase:SPBC29A10.14
    Locus tag
    SPOM_SPBC29A10.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rec8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003423.3 (2568938..2570993)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F0-ATPase subunit D Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene origin recognition complex subunit Orc1 Neighboring gene ncRNA Neighboring gene Ragulator-Rag complex subunit Lam1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Kinetochore geometry defined by cohesin within the centromere]. Sakuno T, et al. Tanpakushitsu Kakusan Koso, 2009 Nov. PMID 19894585
    2. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination. Sakuno T, et al. Nucleic Acids Res, 2022 Apr 22. PMID 35333350, Free PMC Article
    3. Cohesin Rec8 is required for reductional chromosome segregation at meiosis. Watanabe Y, et al. Nature, 1999 Jul 29. PMID 10440376
    4. Distinct cohesin complexes organize meiotic chromosome domains. Kitajima TS, et al. Science, 2003 May 16. PMID 12750522
    5. Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. Ding DQ, et al. J Cell Biol, 2006 Aug 14. PMID 16893973, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
      Title: Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
    2. Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.
      Title: Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.
    3. Rec8 and Pds5 play an essential role in building a platform to support the chromosome architecture necessary for the spatial alignment of homologous chromosomes.
      Title: Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
    4. balance between Rec8 phosphorylation and its dephosphorylation by Sgo1-PP2A regulates the step-wise loss of chromosomal cohesion in meiosis
      Title: Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
    5. Cohesin within the centromere regulates kinetochore geometry. (review)
      Title: [Kinetochore geometry defined by cohesin within the centromere].
    6. Meiotic prophase chromosomes are organized as chromatin loops emanating from a Rec8-containing axis: the absence of Rec8 disrupts the axis, resulting in disorganized chromosomes.
      Title: Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables topological DNA co-entrapment activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome orientation in meiotic metaphase I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion involved in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle attachment to meiosis I kinetochore EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiotic cohesin complex kleisin subunit Rec8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2568938..2570993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021970.3 → NP_596059.1  meiotic cohesin complex kleisin subunit Rec8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596059.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60051, P36626
      Conserved Domains (2) summary
      pfam04824
      Location:503 → 557
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1 → 93
      Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
    Nucleotide Protein
    Heading Accession and Version

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