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Conserved domains on  [gi|19112851|ref|NP_596059|]
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meiotic cohesin complex kleisin subunit Rec8 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-95 3.18e-35

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 461446  Cd Length: 104  Bit Score: 127.67  E-value: 3.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851     1 MFYNQDVLTKeKGGMGVIWLAATLGskhslRKLHKKDIMSVDIDEACDFVAFSPEPLALRLSSNLMIGVTRVWAHQYSFF 80
Cdd:pfam04825   1 MFYSHEILSK-KGPLATVWLAATLG-----KKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYL 74

                          90
                  ....*....|....*
gi 19112851    81 HSQVSTLHLRVRKEL 95
Cdd:pfam04825  75 LDDCNEALVKIKKAF 89
Rad21_Rec8_M_SpRec8p-like cd21789
Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination ...
 284-386 1.37e-16

Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination protein Rec8 (SpRec8p) and similar proteins; SpRec8p, also called cohesin rec8, is involved primarily in the early steps of meiotic recombination. It is required to ensure reductional chromosome segregation. This model corresponds to a small region in the middle of SpRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


:

Pssm-ID: 439291  Cd Length: 118  Bit Score: 75.96  E-value: 1.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851 284 KRRKVqKLLEPDENIELSTRTLSQWRKNYVERMIALEATKyvRRRGASSAKKKELNKFF------------DWESFHPLL 351
Cdd:cd21789   1 RKRRP-KTIKLDERTELSNSELREWQENYLENMEAASKKK--QRRRLAQAAKKNAAFWVgqgiggvgagvgGGGLSHPLA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19112851 352 KPWIEKL-----KPSNNTPSEIDDVLRNIDTSEVEVGRDV 386
Cdd:cd21789  78 EFFGGELleallGTSERSRARKRRRSSGDDDDEEEESRRV 117
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 503-557 2.54e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.05  E-value: 2.54e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19112851   503 NNGRITFSSLLPNDLKRPVVAQAFSHLLSLATKSAFLVKQDKPYSEISVSLNLKS 557
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-95 3.18e-35

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 127.67  E-value: 3.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851     1 MFYNQDVLTKeKGGMGVIWLAATLGskhslRKLHKKDIMSVDIDEACDFVAFSPEPLALRLSSNLMIGVTRVWAHQYSFF 80
Cdd:pfam04825   1 MFYSHEILSK-KGPLATVWLAATLG-----KKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYL 74

                          90
                  ....*....|....*
gi 19112851    81 HSQVSTLHLRVRKEL 95
Cdd:pfam04825  75 LDDCNEALVKIKKAF 89
Rad21_Rec8_M_SpRec8p-like cd21789
Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination ...
 284-386 1.37e-16

Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination protein Rec8 (SpRec8p) and similar proteins; SpRec8p, also called cohesin rec8, is involved primarily in the early steps of meiotic recombination. It is required to ensure reductional chromosome segregation. This model corresponds to a small region in the middle of SpRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439291  Cd Length: 118  Bit Score: 75.96  E-value: 1.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851 284 KRRKVqKLLEPDENIELSTRTLSQWRKNYVERMIALEATKyvRRRGASSAKKKELNKFF------------DWESFHPLL 351
Cdd:cd21789   1 RKRRP-KTIKLDERTELSNSELREWQENYLENMEAASKKK--QRRRLAQAAKKNAAFWVgqgiggvgagvgGGGLSHPLA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19112851 352 KPWIEKL-----KPSNNTPSEIDDVLRNIDTSEVEVGRDV 386
Cdd:cd21789  78 EFFGGELleallGTSERSRARKRRRSSGDDDDEEEESRRV 117
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 503-557 2.54e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.05  E-value: 2.54e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19112851   503 NNGRITFSSLLPNDLKRPVVAQAFSHLLSLATKSAFLVKQDKPYSEISVSLNLKS 557
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M_ScRec8p-like cd21790
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination ...
 485-545 3.30e-06

Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination protein Rec8 (ScRec8p) and similar proteins; ScRec8p, also called cohesin REC8, or sporulation protein 69, replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. It is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. It is protected from cleavage by SPO13. This model corresponds to a small region in the middle of ScRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439292  Cd Length: 92  Bit Score: 45.34  E-value: 3.30e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19112851 485 MEKECANFYEYAKTAIYE----------NNGRITFSSLLPNDLK-------RPVVAQAFSHLLSLATKSAFLVKQDKP 545
Cdd:cd21790   1 LDQQLRKFYEYLKERAEElgkttssdppFKRKILFEDLVPSTSTseeepvsRKIAANAFLSLLTLATKSLVSIEQDPV 78
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-95 3.18e-35

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 127.67  E-value: 3.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851     1 MFYNQDVLTKeKGGMGVIWLAATLGskhslRKLHKKDIMSVDIDEACDFVAFSPEPLALRLSSNLMIGVTRVWAHQYSFF 80
Cdd:pfam04825   1 MFYSHEILSK-KGPLATVWLAATLG-----KKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYL 74

                          90
                  ....*....|....*
gi 19112851    81 HSQVSTLHLRVRKEL 95
Cdd:pfam04825  75 LDDCNEALVKIKKAF 89
Rad21_Rec8_M_SpRec8p-like cd21789
Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination ...
 284-386 1.37e-16

Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination protein Rec8 (SpRec8p) and similar proteins; SpRec8p, also called cohesin rec8, is involved primarily in the early steps of meiotic recombination. It is required to ensure reductional chromosome segregation. This model corresponds to a small region in the middle of SpRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439291  Cd Length: 118  Bit Score: 75.96  E-value: 1.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851 284 KRRKVqKLLEPDENIELSTRTLSQWRKNYVERMIALEATKyvRRRGASSAKKKELNKFF------------DWESFHPLL 351
Cdd:cd21789   1 RKRRP-KTIKLDERTELSNSELREWQENYLENMEAASKKK--QRRRLAQAAKKNAAFWVgqgiggvgagvgGGGLSHPLA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19112851 352 KPWIEKL-----KPSNNTPSEIDDVLRNIDTSEVEVGRDV 386
Cdd:cd21789  78 EFFGGELleallGTSERSRARKRRRSSGDDDDEEEESRRV 117
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 503-557 2.54e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.05  E-value: 2.54e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19112851   503 NNGRITFSSLLPNDLKRPVVAQAFSHLLSLATKSAFLVKQDKPYSEISVSLNLKS 557
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M cd21747
Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic ...
 284-369 3.97e-07

Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic cohesins of the Rad21, Rec8, and Scc1 subfamilies. They mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation. This model corresponds to a conserved middle/central region of family members, consisting of short helices and two extended segments, which functions in binding to HEAT-repeat containing cohesin subunits. For example, human Scc1 homolog (NXP-1) binds to either SA1 or SA2, two homologous HEAT-containing proteins; the SA-Scc1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439289 [Multi-domain]  Cd Length: 79  Bit Score: 47.84  E-value: 3.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112851 284 KRRKVQKLLePDENIELSTRTLSQWRKNYvermialEATKYVRRRGASS-AKKKELNKFFDWESFHPLLKPWIEKLKpsN 362
Cdd:cd21747   1 RRRRKRKLL-IDEVTELSTEQMRSQLQDT-------SDIVRSRDLNPPTpVRPLRKASGTDSLFSLNPLSGWDNALL--E 70


                ....*..
gi 19112851 363 NTPSEID 369
Cdd:cd21747  71 LFPSPLR 77
Rad21_Rec8_M_ScRec8p-like cd21790
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination ...
 485-545 3.30e-06

Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination protein Rec8 (ScRec8p) and similar proteins; ScRec8p, also called cohesin REC8, or sporulation protein 69, replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. It is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. It is protected from cleavage by SPO13. This model corresponds to a small region in the middle of ScRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439292  Cd Length: 92  Bit Score: 45.34  E-value: 3.30e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19112851 485 MEKECANFYEYAKTAIYE----------NNGRITFSSLLPNDLK-------RPVVAQAFSHLLSLATKSAFLVKQDKP 545
Cdd:cd21790   1 LDQQLRKFYEYLKERAEElgkttssdppFKRKILFEDLVPSTSTseeepvsRKIAANAFLSLLTLATKSLVSIEQDPV 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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