paxip1 PAX interacting (with transcription-activation domain) protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: paxip1provided by ZNC
Official Full Name: PAX interacting (with transcription-activation domain) protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-214
See related: Ensembl:ENSDARG00000005606 AllianceGenome:ZFIN:ZDB-GENE-041010-214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa04b06; zgc:92593; wu:fa04b06
Summary: Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Orthologous to human PAXIP1 (PAX interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (29902676..29923406, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (29919143..29939870, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PAX-interacting protein 1

Names: PAX transactivation activation domain-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005929.2 → NP_001005929.2 PAX-interacting protein 1

Status: VALIDATED

Source sequence(s)

AI877856, CR855328, EB910284

UniProtKB/Swiss-Prot

Q5XIY8

UniProtKB/TrEMBL

A0A8M1N2L1, F1Q5Z1

Related

ENSDARP00000113779.1, ENSDART00000144672.3

Conserved Domains (3) summary

smart00292
Location:10 → 77

BRCT; breast cancer carboxy-terminal domain

cd00027
Location:921 → 988

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

pfam12738
Location:764 → 825

PTCB-BRCT; twin BRCT domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

29902676..29923406 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480006.2 → XP_021335681.1 PAX-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5XIY8

UniProtKB/TrEMBL

A0A8M9QII6

Related

ENSDARP00000131783.2, ENSDART00000158844.3

Conserved Domains (5) summary

smart00292
Location:10 → 77

BRCT; breast cancer carboxy-terminal domain

pfam00533
Location:656 → 731

BRCT; BRCA1 C Terminus (BRCT) domain

pfam12738
Location:764 → 825

PTCB-BRCT; twin BRCT domain

pfam16770
Location:910 → 1000

RTT107_BRCT_5; Regulator of Ty1 transposition protein 107 BRCT domain

cl00038
Location:102 → 164

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...