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Conserved domains on  [gi|836939487|ref|NP_001005929|]
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PAX-interacting protein 1 [Danio rerio]

Protein Classification

PAX interacting protein 1( domain architecture ID 13026270)

PAX interacting protein 1 (PAXIP1, also termed PTIP) is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes

Gene Ontology:  GO:0044666|GO:0006281|GO:0006310
PubMed:  10908331|19229280|20088963

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_PAXIP1_rpt6 cd18440
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 1025-1115 1.83e-46

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the sixth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


:

Pssm-ID: 349393  Cd Length: 90  Bit Score: 161.23  E-value: 1.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1025 LFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKIMEhKQNKNLPEIILITCENDSHLCREYFLKNIEVYTAEL 1104
Cdd:cd18440     1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKKRPSLKKIME-KNNQGPPSYIIITCENDLHLCRDLFRKNIDVYNAEF 79

                          90
                  ....*....|.
gi 836939487 1105 ILTGVLTQSLD 1115
Cdd:cd18440    80 ILTGVLRQKLD 90
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 98-177 1.00e-41

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


:

Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 147.38  E-value: 1.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   98 VFFGVTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKD 176
Cdd:cd17710     1 LFSGVVVCPSQIsAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                  .
gi 836939487  177 E 177
Cdd:cd17710    81 E 81
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 919-993 3.09e-41

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


:

Pssm-ID: 349344  Cd Length: 75  Bit Score: 145.46  E-value: 3.09e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  919 TPYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17712     1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 763-835 4.77e-41

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


:

Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 145.08  E-value: 4.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487  763 HIISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLCDILLGNFE 835
Cdd:cd17730     1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73
BRCT_PAXIP1_rpt1 cd17714
first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...
 13-87 4.46e-38

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.


:

Pssm-ID: 349346  Cd Length: 76  Bit Score: 136.68  E-value: 4.46e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487   13 FKDVKFYVVGDIDQKVVQLLKSGKGKEVSYNA-LATHIIAEDGDNPEVGESREVFDLPVVKPSWVILSVKCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 663-743 1.79e-37

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


:

Pssm-ID: 349343  Cd Length: 81  Bit Score: 135.08  E-value: 1.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  663 GCIFAIADYPEQMADkQLLATWKRIIQLNGGTVDSAL-NRCTHLLCESQVSNTYLQALREGKRCVTAHWLNTVLKKKKMV 741
Cdd:cd17711     1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYsPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                  ..
gi 836939487  742 PP 743
Cdd:cd17711    80 PP 81
 
Name Accession Description Interval E-value
BRCT_PAXIP1_rpt6 cd18440
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 1025-1115 1.83e-46

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the sixth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349393  Cd Length: 90  Bit Score: 161.23  E-value: 1.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1025 LFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKIMEhKQNKNLPEIILITCENDSHLCREYFLKNIEVYTAEL 1104
Cdd:cd18440     1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKKRPSLKKIME-KNNQGPPSYIIITCENDLHLCRDLFRKNIDVYNAEF 79

                          90
                  ....*....|.
gi 836939487 1105 ILTGVLTQSLD 1115
Cdd:cd18440    80 ILTGVLRQKLD 90
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 98-177 1.00e-41

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 147.38  E-value: 1.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   98 VFFGVTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKD 176
Cdd:cd17710     1 LFSGVVVCPSQIsAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                  .
gi 836939487  177 E 177
Cdd:cd17710    81 E 81
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 919-993 3.09e-41

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 145.46  E-value: 3.09e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  919 TPYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17712     1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 763-835 4.77e-41

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 145.08  E-value: 4.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487  763 HIISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLCDILLGNFE 835
Cdd:cd17730     1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73
BRCT_PAXIP1_rpt1 cd17714
first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...
 13-87 4.46e-38

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.


Pssm-ID: 349346  Cd Length: 76  Bit Score: 136.68  E-value: 4.46e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487   13 FKDVKFYVVGDIDQKVVQLLKSGKGKEVSYNA-LATHIIAEDGDNPEVGESREVFDLPVVKPSWVILSVKCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 663-743 1.79e-37

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 135.08  E-value: 1.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  663 GCIFAIADYPEQMADkQLLATWKRIIQLNGGTVDSAL-NRCTHLLCESQVSNTYLQALREGKRCVTAHWLNTVLKKKKMV 741
Cdd:cd17711     1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYsPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                  ..
gi 836939487  742 PP 743
Cdd:cd17711    80 PP 81
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
 912-1000 4.83e-24

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 97.20  E-value: 4.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   912 KKLPPDSTPYVLFTGFE--PLQAQQYIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKS 989
Cdd:pfam16770    1 KKSLPPYDIRAVLTGCErwIDKEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKE 80

                           90
                   ....*....|.
gi 836939487   990 QKFVDEQSYML 1000
Cdd:pfam16770   81 GKLPDEEDYLL 91
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 764-825 2.09e-23

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 94.19  E-value: 2.09e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487   764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQW 825
Cdd:pfam12738    2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 102-164 1.12e-11

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 61.07  E-value: 1.12e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836939487   102 VTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECAlRHNNIKIVTPEW 164
Cdd:pfam12738    1 LVICVTGFdGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKA-KEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
758-830 1.20e-10

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 58.54  E-value: 1.20e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487    758 KPCAQHIISVTG-FVDSDRDDLKLMAYLAGARYTGYLCR-SNTVLICKEPSG--LKYEKAKEWRIPCVNAQWLCDIL 830
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78
BRCT smart00292
breast cancer carboxy-terminal domain;
111-169 3.22e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 51.61  E-value: 3.22e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836939487    111 EDLNALWAFITFYGGDCQLHFNKK-CTHLVVPEPKGAKYECAL-RHNNIKIVTPEWILDSV 169
Cdd:smart00292   18 EERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKaIALGIPIVKEEWLLDCL 78
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 12-91 3.21e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 48.90  E-value: 3.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487    12 LFKDVKFYVV---GDIDQKVVQLLKSGKGKEVSY-NALATHIIAEDGDNPEVGESRevfDLPVVKPSWVILSVKCGDLLP 87
Cdd:pfam16589    4 LFEPLRFYINaipSPSRSKLKRLIEANGGTVVDNiNPAVYIVIAPYNKTDKLAENT---KLGVVSPQWIFDCVKKGKLLP 80


                   ....
gi 836939487    88 VTGF 91
Cdd:pfam16589   81 LENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
922-987 3.72e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.53  E-value: 3.72e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487    922 VLFTG-FEPLQAQQYIKKLYDLGGEVADSTQK--CTHLVANKV-TRTVKFLTAISVVKHIVTPEWLEESW 987
Cdd:smart00292    9 FYITGsFDKEERDELKELIEALGGKVTSSLSSktTTHVIVGSPeGGKLELLKAIALGIPIVKEEWLLDCL 78
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 656-731 1.61e-06

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 46.90  E-value: 1.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487   656 PEEGFLVGCIFAIadYPEQMADKQLLatwKRIIQLNGGTVDSALNR-CTHLLCESQVSNtYLQALREGKRCVTAHWL 731
Cdd:pfam00533    1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKkTTHVIVEARTKK-YLKAKELGIPIVTEEWL 71
BRCT smart00292
breast cancer carboxy-terminal domain;
663-731 9.50e-06

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 44.67  E-value: 9.50e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487    663 GCIFAIADYPeqmaDKQLLATWKRIIQLNGGTVDSALNR--CTHLLCESQV--SNTYLQALREGKRCVTAHWL 731
Cdd:smart00292    6 GKTFYITGSF----DKEERDELKELIEALGGKVTSSLSSktTTHVIVGSPEggKLELLKAIALGIPIVKEEWL 74
BRCT smart00292
breast cancer carboxy-terminal domain;
10-77 1.49e-05

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 44.29  E-value: 1.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487     10 EELFKDVKFYVVGDIDQ----KVVQLLKSGKGKEVSY--NALATHIIAEDGDNPEVGESREVF-DLPVVKPSWVI 77
Cdd:smart00292    1 PKLFKGKTFYITGSFDKeerdELKELIEALGGKVTSSlsSKTTTHVIVGSPEGGKLELLKAIAlGIPIVKEEWLL 75
 
Name Accession Description Interval E-value
BRCT_PAXIP1_rpt6 cd18440
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 1025-1115 1.83e-46

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the sixth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349393  Cd Length: 90  Bit Score: 161.23  E-value: 1.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1025 LFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKIMEhKQNKNLPEIILITCENDSHLCREYFLKNIEVYTAEL 1104
Cdd:cd18440     1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKKRPSLKKIME-KNNQGPPSYIIITCENDLHLCRDLFRKNIDVYNAEF 79

                          90
                  ....*....|.
gi 836939487 1105 ILTGVLTQSLD 1115
Cdd:cd18440    80 ILTGVLRQKLD 90
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 98-177 1.00e-41

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 147.38  E-value: 1.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   98 VFFGVTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKD 176
Cdd:cd17710     1 LFSGVVVCPSQIsAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                  .
gi 836939487  177 E 177
Cdd:cd17710    81 E 81
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 919-993 3.09e-41

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 145.46  E-value: 3.09e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  919 TPYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17712     1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 763-835 4.77e-41

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 145.08  E-value: 4.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487  763 HIISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLCDILLGNFE 835
Cdd:cd17730     1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73
BRCT_PAXIP1_rpt1 cd17714
first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...
 13-87 4.46e-38

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.


Pssm-ID: 349346  Cd Length: 76  Bit Score: 136.68  E-value: 4.46e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487   13 FKDVKFYVVGDIDQKVVQLLKSGKGKEVSYNA-LATHIIAEDGDNPEVGESREVFDLPVVKPSWVILSVKCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 663-743 1.79e-37

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 135.08  E-value: 1.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  663 GCIFAIADYPEQMADkQLLATWKRIIQLNGGTVDSAL-NRCTHLLCESQVSNTYLQALREGKRCVTAHWLNTVLKKKKMV 741
Cdd:cd17711     1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYsPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                  ..
gi 836939487  742 PP 743
Cdd:cd17711    80 PP 81
BRCT_PAXIP1_rpt6_like cd18432
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA ...
 1025-1115 1.05e-25

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the sixth BRCT domain of PAXIP1 and the second BRCT domain of MDC1.


Pssm-ID: 349385 [Multi-domain]  Cd Length: 85  Bit Score: 101.51  E-value: 1.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1025 LFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSyRKIMEHKQNknlpeIILITCENDSHLCREYFLKNIEVYTAEL 1104
Cdd:cd18432     1 LFEGYTFYVTPNVKPPPEELKEIIEAAGGKVLKKLPT-KRIEDDDPD-----TIVISCEEDRKLWKPLKKKGIPIYSVEF 74

                          90
                  ....*....|.
gi 836939487 1105 ILTGVLTQSLD 1115
Cdd:cd18432    75 ILTGILRQKLD 85
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 920-993 1.41e-24

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 98.07  E-value: 1.41e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836939487  920 PYVLFTGFEPLQAQQyiKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17744     1 PRVLFTGVSDKEEGE--KIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
 912-1000 4.83e-24

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 97.20  E-value: 4.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   912 KKLPPDSTPYVLFTGFE--PLQAQQYIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKS 989
Cdd:pfam16770    1 KKSLPPYDIRAVLTGCErwIDKEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKE 80

                           90
                   ....*....|.
gi 836939487   990 QKFVDEQSYML 1000
Cdd:pfam16770   81 GKLPDEEDYLL 91
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 764-825 2.09e-23

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 94.19  E-value: 2.09e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487   764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQW 825
Cdd:pfam12738    2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT_BRC1_like_rpt5 cd17743
fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 921-990 1.37e-18

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.


Pssm-ID: 349374  Cd Length: 70  Bit Score: 80.75  E-value: 1.37e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  921 YVLFTGFEPLQAQQyIKKLYDLGGEVADSTQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQ 990
Cdd:cd17743     2 RLLFTGYKLWTEKE-IKKLKKLGISIVEDPDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEACLKAG 70
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 98-170 1.20e-15

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 72.57  E-value: 1.20e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836939487   98 VFFGVTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVK 170
Cdd:cd17731     2 PFKGLVICVTGFdSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSIHIVTPEWLYDSIE 75
BRCT_BRC1_like_rpt6 cd18439
sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...
 1006-1115 3.91e-15

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.


Pssm-ID: 349392  Cd Length: 116  Bit Score: 72.72  E-value: 3.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1006 EVLFSFSLEESLKRAHA--APLFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKImeHKQNKNLPEIILITCE 1083
Cdd:cd18439     1 EKKYGCTLAESLARAKAnkGKLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKL--GDGIAEKGPVVLISTT 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 836939487 1084 NDSHLcREYFLKNIE-------VYTAELILTGVLTQSLD 1115
Cdd:cd18439    79 KEKKL-WPKFLKNAReggkeprVYSTDWLLDVVLRQELV 116
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 919-990 6.84e-15

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 70.67  E-value: 6.84e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  919 TPYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQ---KCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQ 990
Cdd:cd17738     1 KPVFLLSGFSEDEKKELISIIEKLGGKVLDSDEfdpKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKAG 75
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 758-830 1.42e-14

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 69.63  E-value: 1.42e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487   758 KPCAQHIISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSgLKYEKAKEWRIPCVNAQWLCDIL 830
Cdd:pfam00533    4 KLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEART-KKYLKAKELGIPIVTEEWLLDCI 75
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 920-986 2.64e-14

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 68.54  E-value: 2.64e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836939487  920 PYVLFTGFEPLQAQQYIKKLYDLGGEVADS-TQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEES 986
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESlSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 764-826 3.90e-14

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 68.87  E-value: 3.90e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487  764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCR---------SNTVLICKEPSGLKYEKAKEWRIPCVNAQWL 826
Cdd:cd18434     6 VISVSQFTGTERDCLTHLAELLGAKVQDYFVRkanpskgllASTHLVLKEPEGSKYEAAKKWNLPAVTKSWL 77
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 764-828 7.89e-14

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 67.57  E-value: 7.89e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWR-IPCVNAQWLCD 828
Cdd:cd17731     7 VICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYD 72
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 764-828 1.01e-13

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 67.02  E-value: 1.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLCD 828
Cdd:cd18438     2 KITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYD 66
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 764-826 1.75e-13

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 66.23  E-value: 1.75e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836939487  764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKY-EKAKEWRIPCVNAQWL 826
Cdd:cd00027     2 VICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWL 65
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 104-168 2.17e-13

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 65.85  E-value: 2.17e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  104 ACLPHLAEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDS 168
Cdd:cd00027     4 CFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT_MDC1_rpt2 cd18441
second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 1025-1115 3.45e-12

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the second BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349394  Cd Length: 81  Bit Score: 63.17  E-value: 3.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487 1025 LFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKimehkqnknlPEIILITCENDSHLCREYFLKNIEVYTAEL 1104
Cdd:cd18441     1 LLEGYEIHVTPGVKPEPPQMKDIITCAGGTFLPSMPKTYK----------PQTVVISCPEDFPHCSPALKAGLPVVSAEF 70

                          90
                  ....*....|.
gi 836939487 1105 ILTGVLTQSLD 1115
Cdd:cd18441    71 LLTGILRQEAD 81
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 102-164 1.12e-11

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 61.07  E-value: 1.12e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836939487   102 VTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECAlRHNNIKIVTPEW 164
Cdd:pfam12738    1 LVICVTGFdGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKA-KEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
758-830 1.20e-10

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 58.54  E-value: 1.20e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487    758 KPCAQHIISVTG-FVDSDRDDLKLMAYLAGARYTGYLCR-SNTVLICKEPSG--LKYEKAKEWRIPCVNAQWLCDIL 830
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 99-170 4.64e-10

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 56.85  E-value: 4.64e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487   99 FFGVTACLPHLAE-DLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHN--NIKIVTPEWILDSVK 170
Cdd:cd18436     1 FSGVVITCSDLPSgDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKRPelNIKIVLPHWFDDCFK 75
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 922-987 4.80e-10

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 56.92  E-value: 4.80e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487   922 VLFTGFEPLQAQQYIKKLYDLGGEVADS-TQKCTHLVANKvtRTVKFLTAISVVKHIVTPEWLEESW 987
Cdd:pfam00533   11 FVITGLDGLERDELKELIEKLGGKVTDSlSKKTTHVIVEA--RTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 765-830 1.76e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 54.96  E-value: 1.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836939487  765 ISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICK--EPSGLKYEKAKEWRIPCVNAQWLCDIL 830
Cdd:cd17723     4 ISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKWGIPVVSVEWLWDCL 71
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 942-985 7.46e-09

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 53.37  E-value: 7.46e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 836939487  942 LGGEVADS-TQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEE 985
Cdd:cd17741    25 LGGKVVNEwTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDA 69
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 105-177 1.45e-08

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 53.08  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  105 CLPHLAEDLNALwafitfyggdCQLHFNKK---------CTHLVVPEPKGAKYECALRHnNIKIVTPEWILDSVKEKNRK 175
Cdd:cd18434    19 CLTHLAELLGAK----------VQDYFVRKanpskgllaSTHLVLKEPEGSKYEAAKKW-NLPAVTKSWLFECARTGKKV 87


                  ..
gi 836939487  176 DE 177
Cdd:cd18434    88 PE 89
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 116-180 2.68e-08

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 52.19  E-value: 2.68e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  116 LWAFITFYGGDCQLHFNK-KCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKDEMLY 180
Cdd:cd17719    20 LKRLILLHGGQYEHYYSRsRVTHIIATNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRLLPEAPY 85
BRCT smart00292
breast cancer carboxy-terminal domain;
111-169 3.22e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 51.61  E-value: 3.22e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836939487    111 EDLNALWAFITFYGGDCQLHFNKK-CTHLVVPEPKGAKYECAL-RHNNIKIVTPEWILDSV 169
Cdd:smart00292   18 EERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKaIALGIPIVKEEWLLDCL 78
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 116-177 7.20e-08

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 51.38  E-value: 7.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487  116 LWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKDE 177
Cdd:cd17729    36 LWKLAESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMPGIHVVHPDWLWACAERWERVDE 97
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 925-989 1.06e-07

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 50.23  E-value: 1.06e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836939487  925 TGFEPLQAQQYIKKLYDLGGEV-ADSTQKCTHLVANKVTrTVKFLTAI--SVVkHIVTPEWLEESWKS 989
Cdd:cd17731    11 TGFDSEERKEIQQLVEQNGGSYsPDLSKNCTHLIAGSPS-GQKYEFARkwNSI-HIVTPEWLYDSIEA 76
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
 920-993 1.42e-07

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 49.90  E-value: 1.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  920 PYVLFTGFEPLQAQQYIKKLYDLGG-EVADS-TQKCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17736     1 RTLVMTSVHSEEQELLESVVKKLGGfRVEDSvTEKTTHVVVGSPRRTLNVLLGIARGCWILSPDWVLESLEAGKWL 76
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 772-828 1.50e-07

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 49.64  E-value: 1.50e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 836939487  772 DSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWL--CD 828
Cdd:cd17742    13 PESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLraCE 71
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 685-738 2.07e-07

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 49.46  E-value: 2.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  685 KRIIQLNGGTVDSALNR-CTHLLCESQVSNTYLQALREGK-RCVTAHWLNTVLKKK 738
Cdd:cd17731    22 QQLVEQNGGSYSPDLSKnCTHLIAGSPSGQKYEFARKWNSiHIVTPEWLYDSIEAG 77
BRCT_DNA_ligase_III cd18431
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ...
 98-176 3.16e-07

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.


Pssm-ID: 349384 [Multi-domain]  Cd Length: 78  Bit Score: 48.85  E-value: 3.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   98 VFFGVTACLPHLAED-LNALWAFITFYGGDCQLHFNKK-CTHLVVPEPKGAKyecalrHNNIKIVTPEWILDSVKEKNRK 175
Cdd:cd18431     4 IFTGVKVYLPGSVEDdYKKLKRYFIAYDGDVVEEYDEEdATHVVVDRDDKLG------NPSAKVVSPEWLWDCIKKQKLV 77


                  .
gi 836939487  176 D 176
Cdd:cd18431    78 P 78
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 12-91 3.21e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 48.90  E-value: 3.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487    12 LFKDVKFYVV---GDIDQKVVQLLKSGKGKEVSY-NALATHIIAEDGDNPEVGESRevfDLPVVKPSWVILSVKCGDLLP 87
Cdd:pfam16589    4 LFEPLRFYINaipSPSRSKLKRLIEANGGTVVDNiNPAVYIVIAPYNKTDKLAENT---KLGVVSPQWIFDCVKKGKLLP 80


                   ....
gi 836939487    88 VTGF 91
Cdd:pfam16589   81 LENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
922-987 3.72e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.53  E-value: 3.72e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487    922 VLFTG-FEPLQAQQYIKKLYDLGGEVADSTQK--CTHLVANKV-TRTVKFLTAISVVKHIVTPEWLEESW 987
Cdd:smart00292    9 FYITGsFDKEERDELKELIEALGGKVTSSLSSktTTHVIVGSPeGGKLELLKAIALGIPIVKEEWLLDCL 78
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 118-169 5.82e-07

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 48.06  E-value: 5.82e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 836939487   118 AFITFYGGDCQLHFNKKCTHLVVpEPKGAKYECALRHNnIKIVTPEWILDSV 169
Cdd:pfam00533   26 ELIEKLGGKVTDSLSKKTTHVIV-EARTKKYLKAKELG-IPIVTEEWLLDCI 75
BRCT_SLF1 cd17750
BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; ...
 920-995 8.94e-07

BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; SLF1, also termed Smc5/6 localization factor 1, or ankyrin repeat domain-containing protein 32 (ANKRD32), or BRCT domain-containing protein 1 (BRCTD1), plays a role in the DNA damage response (DDR) pathway by regulating post replication repair of UV-damaged DNA and genomic stability maintenance. It is a component of the SLF1-SLF2 complex that acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand break (DSB) sites on chromatin during DNA repair in response to stalled replication forks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349381  Cd Length: 81  Bit Score: 47.89  E-value: 8.94e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836939487  920 PYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQ--KCTHLVANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFVDE 995
Cdd:cd17750     4 HIIQLTGFKGEEKEALVKLLLKLDCVFIKSEKyeNCTHLIAKKPCRSEKFLAACAAGKWILTKDYIINSAKSGRWLDE 81
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 656-731 1.61e-06

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 46.90  E-value: 1.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487   656 PEEGFLVGCIFAIadYPEQMADKQLLatwKRIIQLNGGTVDSALNR-CTHLLCESQVSNtYLQALREGKRCVTAHWL 731
Cdd:pfam00533    1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKkTTHVIVEARTKK-YLKAKELGIPIVTEEWL 71
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 677-731 1.63e-06

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 46.59  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 836939487  677 DKQLLATWKRIIQLNGGTVDSALNR-CTHLLCESQVSNTY-LQALREGKRCVTAHWL 731
Cdd:cd00027     9 DDEEREELKKLIEALGGKVSESLSSkVTHLIAKSPSGEKYyLAALAWGIPIVSPEWL 65
BRCT smart00292
breast cancer carboxy-terminal domain;
663-731 9.50e-06

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 44.67  E-value: 9.50e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487    663 GCIFAIADYPeqmaDKQLLATWKRIIQLNGGTVDSALNR--CTHLLCESQV--SNTYLQALREGKRCVTAHWL 731
Cdd:smart00292    6 GKTFYITGSF----DKEERDELKELIEALGGKVTSSLSSktTTHVIVGSPEggKLELLKAIALGIPIVKEEWL 74
BRCT smart00292
breast cancer carboxy-terminal domain;
10-77 1.49e-05

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 44.29  E-value: 1.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487     10 EELFKDVKFYVVGDIDQ----KVVQLLKSGKGKEVSY--NALATHIIAEDGDNPEVGESREVF-DLPVVKPSWVI 77
Cdd:smart00292    1 PKLFKGKTFYITGSFDKeerdELKELIEALGGKVTSSlsSKTTTHVIVGSPEGGKLELLKAIAlGIPIVKEEWLL 75
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 130-170 1.68e-05

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 43.77  E-value: 1.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 836939487  130 HFNKKCTHLVVPEPKGAKYECALRHnNIKIVTPEWILDSVK 170
Cdd:cd17730    30 YLTRSNTHLICKRPEGEKYEKAKEW-RIPVVNAQWLEDILL 69
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 922-995 2.62e-05

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 44.06  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  922 VLFTGFEPLQA---QQYIKKLYD-LGGEVADS-TQKCTHLVANKvTRTVKFLTAI-SVVKHIVTPEWLEESWKSQKFVDE 995
Cdd:cd17729    19 IVFSGVIPTGIdpeRSRLWKLAEsLGAKVVTDlSPRTTHLVAAK-LGTEKVKQALkMPGIHVVHPDWLWACAERWERVDE 97
LIG3_BRCT pfam16759
DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT ...
 98-172 3.01e-05

DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT domain of the scaffolding protein X-ray repair cross-complementing protein 1 (XRCC1) and mediates homo- and heterodimerization.


Pssm-ID: 465260  Cd Length: 77  Bit Score: 43.13  E-value: 3.01e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487    98 VFFGVTACLPHLAEDLNALWAFITFYGGD-CQLHFNKKCTHLVVPEPKGAKYECAlrhNNIKIVTPEWILDSVKEK 172
Cdd:pfam16759    5 IFTGVRLFLPPSVPDFSKLRRYFIAYDGDlVQEYDLDSATHVVVPKDSAKEKEES---SGAKHVTASWIWECIKKR 77
BRCT_Ect2_rpt1 cd17733
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 922-987 3.54e-05

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.


Pssm-ID: 349365 [Multi-domain]  Cd Length: 76  Bit Score: 43.08  E-value: 3.54e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836939487  922 VLFTGFeplQAQQYIKKLYDL----GGEV-ADSTQKCTHLVANKvTRTVKFLTAISVVKHIVTPEWLEESW 987
Cdd:cd17733     6 LCFTGF---RKKEELSRLVNLvhhmGGSIrKDFSSKVTHLVANS-TQGEKYRVAVSLGTPIMTEDWIYKAW 72
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 950-995 9.68e-05

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 41.83  E-value: 9.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 836939487  950 TQKCTHLVANKvTRTVKFLTAIsvvKH----IVTPEWLEESWKSQKFVDE 995
Cdd:cd17710    36 DKKCTHLVTGK-ASGAKYECAL---KHegikIVTPDWVTDCIKAKTLLDE 81
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 925-989 1.05e-04

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 41.63  E-value: 1.05e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  925 TGFEPLQAQQYIKKLYDLGGEVA-DSTQKCTHLVANKVTrTVKFLTAISVVKHIVTPEWLEESWKS 989
Cdd:cd17737     7 TSLEKEEREEVHKYVQLMGGRVSrDLTVSVTHLIAGEVG-SKKYLVAASLKKPIMLPSWVKTLWEK 71
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 663-743 1.08e-04

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 41.83  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  663 GCIFAIAdypeQMADKQLLATWkRIIQLNGGTVDSALN-RCTHLLCESQVSNTYLQALREGK-RCVTAHWLNTVLKKKKM 740
Cdd:cd17710     4 GVVVCPS----QISAEDRLKLW-AMVTFHGGKCQLNLDkKCTHLVTGKASGAKYECALKHEGiKIVTPDWVTDCIKAKTL 78


                  ...
gi 836939487  741 VPP 743
Cdd:cd17710    79 LDE 81
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 132-175 1.36e-04

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 41.55  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 836939487  132 NKKCTHLVVPEPKGAKYECALRhNNIKIVTPEWiLDSVkEKNRK 175
Cdd:cd17742    35 AIDTTHFVCTVPSGPEYEKAKE-MNIPIVRPEW-LRAC-EVEKK 75
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 12-91 1.53e-04

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 41.40  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   12 LFKDVKFYVVGDIDQKVVQL----LKSGkGKEVSYNA--LATHIIAEDGDNPEVGESREVFDLPVVKPSWVILSVKCGDL 85
Cdd:cd17719     1 IFKGVVIYVNGYTDPSADELkrliLLHG-GQYEHYYSrsRVTHIIATNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRL 79


                  ....*.
gi 836939487   86 LPVTGF 91
Cdd:cd17719    80 LPEAPY 85
BRCT_PARP4_like cd17726
BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also ...
 114-172 2.36e-04

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349358 [Multi-domain]  Cd Length: 85  Bit Score: 41.12  E-value: 2.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836939487  114 NALWAFITFYGGDCQLHFNKKCTHLVVPEPKG-AKYEC-ALRHNNIKIVTPEWILDSVKEK 172
Cdd:cd17726    21 KKLKKKITENGGIISYIINKKCTHVVVNNAKAlSSYKCrMAQKYGIPVVSLDYIWKCVEAG 81
BRCT_Bard1_rpt1 cd17734
first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...
 931-993 2.89e-04

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.


Pssm-ID: 349366  Cd Length: 80  Bit Score: 40.66  E-value: 2.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  931 QAQQYIKKLYD-LGGEVADS-TQKCTHLVA-----NKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFV 993
Cdd:cd17734    11 EQKKLLEKLAQlLKAKVVTEfSPEVTHVVVpaderGVCPRTMKYLMGILAGKWIVSFEWVEACLKAKKLV 80
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 101-167 2.96e-04

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 40.27  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487  101 GVTACLP-HLAEDLNALWAFITFYGGDCQLHFNKKCTHLV-----VPEPKGAKyecALRHNNIKIVTPEWILD 167
Cdd:cd17727     3 GVVICVSkKLSKRQGELNKIAASLGAEYRWTYDESCTHFIyqgkaNDTNREYK---SAKEQGKFIVSPHWLYA 72
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 99-170 3.47e-04

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 40.68  E-value: 3.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 836939487   99 FFGVTACLPHL-AEDLNALWAFITFYGGDCQLHFNKKCTHLVVPEPKGAKYECALRHnNIKIVTPEWILDSVK 170
Cdd:cd17746     7 LFKCRVCLTNIgQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKW-KINVVCVEWLWQSIQ 78
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 111-172 4.78e-04

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 39.86  E-value: 4.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487  111 EDLNALWAFITFYGGDCQL--HFNKKCTHLVVPEPK-GAKYECALRhNNIKIVTPEWILDSVKEK 172
Cdd:cd17738    12 DEKKELISIIEKLGGKVLDsdEFDPKCTHLICGKPSrSEKFLAACA-AGKWILHPSYIEASAKAG 75
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 764-828 6.60e-04

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 39.52  E-value: 6.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  764 IISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKA-KEWRIPCVNAQWLCD 828
Cdd:cd17710     6 VVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTD 71
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 133-172 8.54e-04

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 39.14  E-value: 8.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 836939487  133 KKCTHLVVPEPK-GAKYECAL---RHnnikIVTPEWILDSVKEK 172
Cdd:cd17712    33 QECTHLVAPKVSrTVKFLTAIsvcKH----IVTPEWLEESFKQG 72
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 98-172 1.53e-03

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 38.50  E-value: 1.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 836939487    98 VFFgVTACLPHLAEDLNALwafITFYGGDCQLHFNKKCTHLVVPEPKGAKyecALRHNNIKIVTPEWILDSVKEK 172
Cdd:pfam16589    9 RFY-INAIPSPSRSKLKRL---IEANGGTVVDNINPAVYIVIAPYNKTDK---LAENTKLGVVSPQWIFDCVKKG 76
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 949-1000 1.58e-03

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 38.70  E-value: 1.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 836939487  949 STQKCTHLVANKVTRT-VKFLTAISVVKhIVTPEWLEESWKSQKFVDEQSYML 1000
Cdd:cd17719    36 SRSRVTHIIATNLPGSkIKKLKKARNYK-VVRPEWIVDSIKAGRLLPEAPYLL 87
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 663-745 1.69e-03

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 38.50  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487   663 GCIFAIADYPEQMADKqllatWKRIIQLNGGTV-DSALNRCTHLLCESqvSNTYLQALREGKRCVTAHWLNTVLKKKKMV 741
Cdd:pfam16589    7 PLRFYINAIPSPSRSK-----LKRLIEANGGTVvDNINPAVYIVIAPY--NKTDKLAENTKLGVVSPQWIFDCVKKGKLL 79


                   ....
gi 836939487   742 PPHR 745
Cdd:pfam16589   80 PLEN 83
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 119-172 2.28e-03

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 38.01  E-value: 2.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 836939487  119 FITFYGGDCQLHFNKKCTHLVVP--EPKGAKYECALRHNnIKIVTPEWILDSVKEK 172
Cdd:cd17723    20 LIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKWG-IPVVSVEWLWDCLKEG 74
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 685-741 2.37e-03

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 37.99  E-value: 2.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 836939487  685 KRIIQLNGGTVDSALNRCTHLLCeSQVSNT--YLQALREGKRCVTAHWLNTVLKKKKMV 741
Cdd:cd17712    18 TKKVTILGGEVVESPQECTHLVA-PKVSRTvkFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 132-180 2.46e-03

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 38.03  E-value: 2.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 836939487  132 NKKCTHLVVPEPKGAKYECALRHNNIkIVTPEWILDSVKEKNRKDEMLY 180
Cdd:cd17725    33 TADCTHLICAFANTPKYKQVKGAGGI-IVSKEWILDCYKKKKRLPWKRY 80
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 935-993 3.61e-03

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 37.56  E-value: 3.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836939487  935 YIKKLYDLGGEVADS-TQKCTHLV-ANKVTRTVKFLTAISVvkHIVTPEWLEESWKSQKFV 993
Cdd:cd17716    20 FRSILEELGAKVVKRlTKTVTHVVfKDGSQSTLEKAKKRNV--KLVSPLWVEACKETGKRV 78
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 685-742 3.93e-03

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 37.55  E-value: 3.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487  685 KRIIQLNGGTVDSALN--RCTHLLCeSQVSNTYLQALREGKRC--VTAHWLNTVLKKKKMVP 742
Cdd:cd17719    21 KRLILLHGGQYEHYYSrsRVTHIIA-TNLPGSKIKKLKKARNYkvVRPEWIVDSIKAGRLLP 81
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 700-742 3.98e-03

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 37.26  E-value: 3.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 836939487  700 NRCTHLLCesQVSNT--YLQALREGKRCVTAHWLNTVLKKKKMVP 742
Cdd:cd17725    34 ADCTHLIC--AFANTpkYKQVKGAGGIIVSKEWILDCYKKKKRLP 76
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 131-174 7.83e-03

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 36.40  E-value: 7.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 836939487  131 FNKKCTHLVVPEPKGAKYECAlRHNNIKIVTPEWILDSVKEKNR 174
Cdd:cd17716    35 LTKTVTHVVFKDGSQSTLEKA-KKRNVKLVSPLWVEACKETGKR 77
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 765-828 7.95e-03

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 36.78  E-value: 7.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836939487  765 ISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSN-TVLICkepSGLKYEKAKEWR----IPCVNAQWLCD 828
Cdd:cd17719     7 IYVNGYTDPSADELKRLILLHGGQYEHYYSRSRvTHIIA---TNLPGSKIKKLKkarnYKVVRPEWIVD 72
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 922-998 8.31e-03

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 36.49  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836939487  922 VLFT--GFE-PLQAQQYIKKLyDLGGEV-ADSTQKCTHLVAnKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFVDEQS 997
Cdd:cd17725     2 VVFVlsGFQnPFRGELRDKAL-EMGAKYrPDWTADCTHLIC-AFANTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKR 79


                  .
gi 836939487  998 Y 998
Cdd:cd17725    80 Y 80
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 16-79 8.47e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 36.19  E-value: 8.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836939487   16 VKFYVVGDIDQ---KVVQLLKSGKGKEV-SYNALATHIIAEDGDNPEVGESREVFDLPVVKPSWVILS 79
Cdd:cd00027     1 LVICFSGLDDEereELKKLIEALGGKVSeSLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 765-826 9.06e-03

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 36.83  E-value: 9.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836939487  765 ISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWL 826
Cdd:cd17746    12 VCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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