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    atf7ip activating transcription factor 7 interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 558977, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atf7ipprovided by ZNC
    Official Full Name
    activating transcription factor 7 interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061103-178
    See related
    Ensembl:ENSDARG00000069619 AllianceGenome:ZFIN:ZDB-GENE-061103-178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa12g02; wu:fa12g02; zgc:152981
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation; protein stabilization; and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See atf7ip in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45570062..45614481, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (44878267..44922686, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:ch211-243a20.3 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b Neighboring gene uncharacterized LOC137495816 Neighboring gene septin 3 Neighboring gene small integral membrane protein 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Samarut E, et al. Front Mol Neurosci, 2016. PMID 27065799, Free PMC Article
    2. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Ko S, et al. J Hepatol, 2016 Feb. PMID 26505118, Free PMC Article
    3. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Wu J, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36577070, Free PMC Article
    4. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
    5. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Xue Y, et al. Cell Rep, 2019 Apr 30. PMID 31042481

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.
      Title: Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152981

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activating transcription factor 7-interacting protein 1
    Names
    MBD1-containing chromatin-associated factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077603.2 → NP_001071071.2  activating transcription factor 7-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      BX537268, EB936980
      UniProtKB/TrEMBL
      A0A8N7UYD8, F8W5Q4
      Related
      ENSDARP00000125013.1, ENSDART00000149155.3
      Conserved Domains (3) summary
      pfam09184
      Location:82 → 227
      PPP4R2; PPP4R2
      pfam16788
      Location:265 → 431
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:741 → 846
      fn3_4; Fibronectin-III type domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      45570062..45614481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160043.5 → XP_005160100.1  activating transcription factor 7-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005160100.1

      UniProtKB/TrEMBL
      A0A0R4IKD6, A0A8M2B6V3
      Conserved Domains (3) summary
      pfam16788
      Location:223 → 387
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:699 → 804
      fn3_4; Fibronectin-III type domain
      cl25732
      Location:56 → 308
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021475024.2 → XP_021330699.1  activating transcription factor 7-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0R4IKD6, A0A8M2B6V3
      Conserved Domains (3) summary
      pfam16788
      Location:223 → 387
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:699 → 804
      fn3_4; Fibronectin-III type domain
      cl25732
      Location:56 → 308
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_068219647.1 → XP_068075748.1  activating transcription factor 7-interacting protein 1 isoform X5

      UniProtKB/Swiss-Prot
      A0JME2, A2BH15
      Related
      ENSDARP00000122892.1, ENSDART00000135089.3

    4. XM_005160044.5 → XP_005160101.1  activating transcription factor 7-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005160101.1

      UniProtKB/TrEMBL
      A0A0R4IKD6, A0A8M2B6V3
      Conserved Domains (3) summary
      pfam16788
      Location:223 → 387
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:699 → 804
      fn3_4; Fibronectin-III type domain
      cl25732
      Location:56 → 308
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_021475019.2 → XP_021330694.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0G7
      Conserved Domains (2) summary
      pfam16788
      Location:266 → 430
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:742 → 847
      fn3_4; Fibronectin-III type domain

    6. XM_005160041.4 → XP_005160098.1  activating transcription factor 7-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6X0
      Conserved Domains (3) summary
      pfam09184
      Location:84 → 229
      PPP4R2; PPP4R2
      pfam16788
      Location:267 → 433
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:743 → 848
      fn3_4; Fibronectin-III type domain

    7. XM_068219634.1 → XP_068075735.1  activating transcription factor 7-interacting protein 1 isoform X3

    8. XM_005160045.5 → XP_005160102.1  activating transcription factor 7-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005160102.1

      UniProtKB/TrEMBL
      A0A0R4IKD6, A0A8M2B6V3
      Conserved Domains (3) summary
      pfam16788
      Location:223 → 387
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:699 → 804
      fn3_4; Fibronectin-III type domain
      cl25732
      Location:56 → 308
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_005160048.5 → XP_005160105.1  activating transcription factor 7-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005160105.1

      UniProtKB/TrEMBL
      A0A0R4IKD6, A0A8M2B6V3
      Related
      ENSDARP00000136294.2, ENSDART00000160961.2
      Conserved Domains (3) summary
      pfam16788
      Location:223 → 387
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:699 → 804
      fn3_4; Fibronectin-III type domain
      cl25732
      Location:56 → 308
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JME2.2 GenPept UniProtKB/Swiss-Prot:A0JME2

    Gene LinkOut

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