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Conserved domains on  [gi|528468894|ref|XP_005160101|]
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activating transcription factor 7-interacting protein 1 isoform X4 [Danio rerio]

Protein Classification

Ig and FN3 domain-containing protein; fibronectin type III domain-containing protein; purple acid phosphatase N-terminal domain-containing protein; receptor tyrosine-protein kinase( domain architecture ID 11073588)

Ig and FN3 domain-containing protein similar to Homo sapiens contactins, which are comprised of six immunoglobulin (Ig)-like domains followed by four fibronectin type III (Fn3) domains anchored to the membrane by glycosylphosphatidylinositol, and to Robo (roundabout) receptors which typically contain five Ig-like domains and three FN3 domains; fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III (FN3) domain-containing protein such as mammalian interleukin-7 receptor subunit alpha; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein such as Drosophila melanogaster Ihog (interference hedgehog) and human neural cell adhesion molecule (NCAM); fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III (FN3) domain-containing protein such as mammalian interleukin-7 receptor subunit alpha; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein such as Drosophila melanogaster Ihog (interference hedgehog) and human neural cell adhesion molecule (NCAM); fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless); fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; fibronectin type III domain-containing protein similar to mammalian interleukin-9 and interleukin-21 receptors, and vertebrate phytanoyl-CoA hydroxylase-interacting protein; purple acid phosphatase N-terminal domain-containing protein; receptor tyrosine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, similar to Sus scrofa insulin-like growth factor 1 (IGF1) receptor that binds IGF1 with high affinity and IGF2 and insulin with a lower affinity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
fn3_4 pfam16794
Fibronectin-III type domain;
699-803 2.25e-44

Fibronectin-III type domain;


:

Pssm-ID: 465273 [Multi-domain]  Cd Length: 101  Bit Score: 154.81  E-value: 2.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  699 PPQQPQLKLARVQsqNGIVLSWCVAETDRNCAAVDTYHLYAYhqdhQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFV 778
Cdd:pfam16794   2 PPQKPTLKLARVP--TGIVLSWNMPDLDPKYAPVESYHLFAY----QENTSTTPSTDSWKKIGDVKALPLPMACTLSQFK 75
                          90       100
                  ....*....|....*....|....*
gi 528468894  779 SGSTYYFAVRAKDVYGRFGPFCEPQ 803
Cdd:pfam16794  76 AGQRYYFAVRAVDIHGRYGPFSDPK 100
ATF7IP_BD super family cl25111
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
236-324 2.77e-22

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


The actual alignment was detected with superfamily member pfam16788:

Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 95.90  E-value: 2.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  236 QLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALqhiNTLQAKISRLAKKFGAA 315
Cdd:pfam16788  12 QINENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIA---TELQAKIARLTKRFKAA 88

                  ....*....
gi 528468894  316 NQASENAKR 324
Cdd:pfam16788  89 LEDLKKCLP 97
 
Name Accession Description Interval E-value
fn3_4 pfam16794
Fibronectin-III type domain;
699-803 2.25e-44

Fibronectin-III type domain;


Pssm-ID: 465273 [Multi-domain]  Cd Length: 101  Bit Score: 154.81  E-value: 2.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  699 PPQQPQLKLARVQsqNGIVLSWCVAETDRNCAAVDTYHLYAYhqdhQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFV 778
Cdd:pfam16794   2 PPQKPTLKLARVP--TGIVLSWNMPDLDPKYAPVESYHLFAY----QENTSTTPSTDSWKKIGDVKALPLPMACTLSQFK 75
                          90       100
                  ....*....|....*....|....*
gi 528468894  779 SGSTYYFAVRAKDVYGRFGPFCEPQ 803
Cdd:pfam16794  76 AGQRYYFAVRAVDIHGRYGPFSDPK 100
ATF7IP_BD pfam16788
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
236-324 2.77e-22

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 95.90  E-value: 2.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  236 QLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALqhiNTLQAKISRLAKKFGAA 315
Cdd:pfam16788  12 QINENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIA---TELQAKIARLTKRFKAA 88

                  ....*....
gi 528468894  316 NQASENAKR 324
Cdd:pfam16788  89 LEDLKKCLP 97
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
221-327 3.34e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894 221 RDGKRARLEGEELEAQLE-----LKITANGGNRDKIEKMVQQL------VEERLRVLQltvfdRSLKELKDRVEKIDNVT 289
Cdd:COG4717  395 EEYQELKEELEELEEQLEellgeLEELLEALDEEELEEELEELeeeleeLEEELEELR-----EELAELEAELEQLEEDG 469
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528468894 290 KQQNALQHINTLQAKISRLAKKFGAANQASENAKRTQD 327
Cdd:COG4717  470 ELAELLQELEELKAELRELAEEWAALKLALELLEEARE 507
 
Name Accession Description Interval E-value
fn3_4 pfam16794
Fibronectin-III type domain;
699-803 2.25e-44

Fibronectin-III type domain;


Pssm-ID: 465273 [Multi-domain]  Cd Length: 101  Bit Score: 154.81  E-value: 2.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  699 PPQQPQLKLARVQsqNGIVLSWCVAETDRNCAAVDTYHLYAYhqdhQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFV 778
Cdd:pfam16794   2 PPQKPTLKLARVP--TGIVLSWNMPDLDPKYAPVESYHLFAY----QENTSTTPSTDSWKKIGDVKALPLPMACTLSQFK 75
                          90       100
                  ....*....|....*....|....*
gi 528468894  779 SGSTYYFAVRAKDVYGRFGPFCEPQ 803
Cdd:pfam16794  76 AGQRYYFAVRAVDIHGRYGPFSDPK 100
ATF7IP_BD pfam16788
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
236-324 2.77e-22

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 95.90  E-value: 2.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894  236 QLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALqhiNTLQAKISRLAKKFGAA 315
Cdd:pfam16788  12 QINENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIA---TELQAKIARLTKRFKAA 88

                  ....*....
gi 528468894  316 NQASENAKR 324
Cdd:pfam16788  89 LEDLKKCLP 97
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
221-327 3.34e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528468894 221 RDGKRARLEGEELEAQLE-----LKITANGGNRDKIEKMVQQL------VEERLRVLQltvfdRSLKELKDRVEKIDNVT 289
Cdd:COG4717  395 EEYQELKEELEELEEQLEellgeLEELLEALDEEELEEELEELeeeleeLEEELEELR-----EELAELEAELEQLEEDG 469
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528468894 290 KQQNALQHINTLQAKISRLAKKFGAANQASENAKRTQD 327
Cdd:COG4717  470 ELAELLQELEELKAELRELAEEWAALKLALELLEEARE 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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