klhl42 kelch-like family, member 42 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klhl42provided by ZNC
Official Full Name: kelch-like family, member 42provided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-190
See related: Ensembl:ENSDARG00000006011 AllianceGenome:ZFIN:ZDB-GENE-041210-190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klhdc5; si:ch211-234f20.7
Summary: Acts upstream of or within endocrine pancreas development; glucose homeostasis; and pancreas regeneration. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17634311..17643025, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (17647082..17653216, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: kelch-like protein 42

Names: kelch domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045136.2 → NP_001038601.2 kelch-like protein 42

See identical proteins and their annotated locations for NP_001038601.2

Status: PROVISIONAL

Source sequence(s)

BC135056

UniProtKB/TrEMBL

A4IGE1

Related

ENSDARP00000014696.6, ENSDART00000007030.7

Conserved Domains (6) summary

smart00612
Location:267 → 309

Kelch; Kelch domain

PHA03098
Location:2 → 455

PHA03098; kelch-like protein; Provisional

cd14821
Location:102 → 154

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

sd00038
Location:209 → 252

Kelch; KELCH repeat [structural motif]

pfam00651
Location:10 → 94

BTB; BTB/POZ domain

pfam01344
Location:209 → 253

Kelch_1; Kelch motif