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Conserved domains on  [gi|148539936|ref|NP_001038601|]
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kelch-like protein 42 [Danio rerio]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 16( domain architecture ID 13335449)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB/POZ domain-containing protein 16 (BTBD16) is a BTB-domain-containing Kelch-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 99-202 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


:

Pssm-ID: 350553  Cd Length: 103  Bit Score: 189.98  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  99 IKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAANVREQIRDIRLKGTATLVAIGDFTHTCLDlANQ 178
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSLKQQLRERRLRGTPALVALGDFLGTPLD-PYQ 79

                         90       100
                 ....*....|....*....|....
gi 148539936 179 DEPWSMLRYGEVEQRWKPLASNLP 202
Cdd:cd18478   80 DEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 1.44e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 151.18  E-value: 1.44e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   5 EQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQV----------DNE 74
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHEsqgdstdtleENE 80

                         90
                 ....*....|...
gi 148539936  75 TLEDLIETASFLQ 87
Cdd:cd18319   81 LLEDLVEAASFLQ 93
PHA03098 super family cl33709
kelch-like protein; Provisional
 2-455 2.79e-31

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 126.42  E-value: 2.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   2 TSPEQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESA------EDSVrlrglsapglELVLEFINTSKVQVDNET 75
Cdd:PHA03098   8 KFCDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlnidYDSF----------NEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  76 LEDLIETASFLQVTSILKL----LLSEIKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAAN----- 146
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLcinyIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNeliki 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 147 --------------VREQIRDIRLKGTATLVAIGD-------------------------------FTHTCL-------- 173
Cdd:PHA03098 158 lsddklnvssedvvLEIIIKWLTSKKNNKYKDICLilkvlritflseegikklkrwklrikkkkivFNKRCIkiiyskky 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 174 ---DLANQDEPWSMLRYGEVEQRWKPLASNLPQDMIN----------VRGYGSAVLDNYLFIVGGYRMTSQEISAAHCYN 240
Cdd:PHA03098 238 nlnKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSeintiidihyVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 241 PSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGG----HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGG 316
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 317 YTSKDRNTN-VLRYCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVGGYTHElearesgrrrlSQTEDMLTVQSYNVQTG 395
Cdd:PHA03098 398 ISKNDELLKtVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYI-----------DNIKVYNIVESYNPVTN 466

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148539936 396 EWLQLKE-NTSKSGPNLtCTLHNDgIYIMSRDVSLPTSQEHRVflkYNIFSDAWEAFRRFP 455
Cdd:PHA03098 467 KWTELSSlNFPRINASL-CIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFP 522
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 99-202 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 189.98  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  99 IKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAANVREQIRDIRLKGTATLVAIGDFTHTCLDlANQ 178
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSLKQQLRERRLRGTPALVALGDFLGTPLD-PYQ 79

                         90       100
                 ....*....|....*....|....
gi 148539936 179 DEPWSMLRYGEVEQRWKPLASNLP 202
Cdd:cd18478   80 DEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 1.44e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 151.18  E-value: 1.44e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   5 EQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQV----------DNE 74
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHEsqgdstdtleENE 80

                         90
                 ....*....|...
gi 148539936  75 TLEDLIETASFLQ 87
Cdd:cd18319   81 LLEDLVEAASFLQ 93
PHA03098 PHA03098
kelch-like protein; Provisional
 2-455 2.79e-31

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 126.42  E-value: 2.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   2 TSPEQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESA------EDSVrlrglsapglELVLEFINTSKVQVDNET 75
Cdd:PHA03098   8 KFCDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlnidYDSF----------NEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  76 LEDLIETASFLQVTSILKL----LLSEIKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAAN----- 146
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLcinyIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNeliki 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 147 --------------VREQIRDIRLKGTATLVAIGD-------------------------------FTHTCL-------- 173
Cdd:PHA03098 158 lsddklnvssedvvLEIIIKWLTSKKNNKYKDICLilkvlritflseegikklkrwklrikkkkivFNKRCIkiiyskky 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 174 ---DLANQDEPWSMLRYGEVEQRWKPLASNLPQDMIN----------VRGYGSAVLDNYLFIVGGYRMTSQEISAAHCYN 240
Cdd:PHA03098 238 nlnKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSeintiidihyVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 241 PSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGG----HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGG 316
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 317 YTSKDRNTN-VLRYCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVGGYTHElearesgrrrlSQTEDMLTVQSYNVQTG 395
Cdd:PHA03098 398 ISKNDELLKtVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYI-----------DNIKVYNIVESYNPVTN 466

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148539936 396 EWLQLKE-NTSKSGPNLtCTLHNDgIYIMSRDVSLPTSQEHRVflkYNIFSDAWEAFRRFP 455
Cdd:PHA03098 467 KWTELSSlNFPRINASL-CIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
194-422 1.37e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 1.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 194 WKPLASnLPqdmINVRGYGSAVLDNYLFIVGGYRMTSqEISAAHCYNPSKNEWNQVASLNQK-RSNFKLLAVSGKLYAVG 272
Cdd:COG3055    3 WSSLPD-LP---TPRSEAAAALLDGKVYVAGGLSGGS-ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 273 G--------HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGGYTSKDRNTNVLRYCPASDAWSVFHSCSA 344
Cdd:COG3055   78 GftganpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 345 HVRKQQ-MLSVEDTIYLVGGYTheleaRESGRRRLSQTEDMLT--------------------------VQSYNVQTGEW 397
Cdd:COG3055  158 PRDHLAaAVLPDGKILVIGGRN-----GSGFSNTWTTLAPLPTaraghaaavlggkilvfggesgfsdeVEAYDPATNTW 232

                        250       260
                 ....*....|....*....|....*
gi 148539936 398 LQLKENTSKSGPNLTCTlHNDGIYI 422
Cdd:COG3055  233 TALGELPTPRHGHAAVL-TDGKVYV 256
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 8-101 1.45e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 1.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936     8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                           90
                   ....*....|....
gi 148539936    88 VTSILKLLLSEIKQ 101
Cdd:smart00225  82 IPGLVELCEEFLLK 95
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 10-101 1.72e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 60.73  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVqVDNETLEDLIETASFLQVT 89
Cdd:pfam00651  15 LVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIP 93

                          90
                  ....*....|..
gi 148539936   90 SILKLLLSEIKQ 101
Cdd:pfam00651  94 SLVDKCEEFLIK 105
Kelch smart00612
Kelch domain;
267-309 3.07e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 3.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 148539936   267 KLYAVGGH----CLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQG 309
Cdd:smart00612   1 KIYVVGGFdggqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 256-296 4.77e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 4.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148539936  256 RSNFKLLAVSGKLYAVGGH----CLGTVECYSPEQDWWTCVAPLP 296
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFdgnqSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 99-202 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 189.98  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  99 IKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAANVREQIRDIRLKGTATLVAIGDFTHTCLDlANQ 178
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSLKQQLRERRLRGTPALVALGDFLGTPLD-PYQ 79

                         90       100
                 ....*....|....*....|....
gi 148539936 179 DEPWSMLRYGEVEQRWKPLASNLP 202
Cdd:cd18478   80 DEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 1.44e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 151.18  E-value: 1.44e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   5 EQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQV----------DNE 74
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHEsqgdstdtleENE 80

                         90
                 ....*....|...
gi 148539936  75 TLEDLIETASFLQ 87
Cdd:cd18319   81 LLEDLVEAASFLQ 93
PHA03098 PHA03098
kelch-like protein; Provisional
 2-455 2.79e-31

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 126.42  E-value: 2.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   2 TSPEQIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESA------EDSVrlrglsapglELVLEFINTSKVQVDNET 75
Cdd:PHA03098   8 KFCDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlnidYDSF----------NEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  76 LEDLIETASFLQVTSILKL----LLSEIKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAAN----- 146
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLcinyIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNeliki 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 147 --------------VREQIRDIRLKGTATLVAIGD-------------------------------FTHTCL-------- 173
Cdd:PHA03098 158 lsddklnvssedvvLEIIIKWLTSKKNNKYKDICLilkvlritflseegikklkrwklrikkkkivFNKRCIkiiyskky 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 174 ---DLANQDEPWSMLRYGEVEQRWKPLASNLPQDMIN----------VRGYGSAVLDNYLFIVGGYRMTSQEISAAHCYN 240
Cdd:PHA03098 238 nlnKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSeintiidihyVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 241 PSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGG----HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGG 316
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 317 YTSKDRNTN-VLRYCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVGGYTHElearesgrrrlSQTEDMLTVQSYNVQTG 395
Cdd:PHA03098 398 ISKNDELLKtVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYI-----------DNIKVYNIVESYNPVTN 466

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148539936 396 EWLQLKE-NTSKSGPNLtCTLHNDgIYIMSRDVSLPTSQEHRVflkYNIFSDAWEAFRRFP 455
Cdd:PHA03098 467 KWTELSSlNFPRINASL-CIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
194-422 1.37e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 1.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 194 WKPLASnLPqdmINVRGYGSAVLDNYLFIVGGYRMTSqEISAAHCYNPSKNEWNQVASLNQK-RSNFKLLAVSGKLYAVG 272
Cdd:COG3055    3 WSSLPD-LP---TPRSEAAAALLDGKVYVAGGLSGGS-ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 273 G--------HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGGYTSKDRNTNVLRYCPASDAWSVFHSCSA 344
Cdd:COG3055   78 GftganpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 345 HVRKQQ-MLSVEDTIYLVGGYTheleaRESGRRRLSQTEDMLT--------------------------VQSYNVQTGEW 397
Cdd:COG3055  158 PRDHLAaAVLPDGKILVIGGRN-----GSGFSNTWTTLAPLPTaraghaaavlggkilvfggesgfsdeVEAYDPATNTW 232

                        250       260
                 ....*....|....*....|....*
gi 148539936 398 LQLKENTSKSGPNLTCTlHNDGIYI 422
Cdd:COG3055  233 TALGELPTPRHGHAAVL-TDGKVYV 256
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-104 1.02e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 90.15  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18255   23 LIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQML 102

                         90
                 ....*....|....*....
gi 148539936  90 SILKL----LLSEIKQENC 104
Cdd:cd18255  103 PVVELceefLKSAMSVENC 121
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
192-365 1.73e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 192 QRWKPLASnLPQDMINvrGYGSAVLDNYLFIVGGYR---MTSQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSGKL 268
Cdd:COG3055   48 NTWSELAP-LPGPPRH--HAAAVAQDGKLYVFGGFTganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 269 YAVGG----HCLGTVECYSPEQDWWTCVAPLPDPLAEFSA-CECQGMIYVMGGYTSKDRNT------------------- 324
Cdd:COG3055  125 YVVGGwddgGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAaVLPDGKILVIGGRNGSGFSNtwttlaplptaraghaaav 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148539936 325 ----------------NVLRYCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVGGYT 365
Cdd:COG3055  205 lggkilvfggesgfsdEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
245-423 4.04e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 4.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 245 EWNQVASLNQKRSNFKLLAVSGKLYAVGGHCLG----TVECYSPEQDWWTCVAPLPDPLAEFSAC-ECQGMIYVMGGYTS 319
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsasnSFEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 320 KDRN----TNVLRYCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVGGYThelearESGRRRlsqtedmlTVQSYNVQTG 395
Cdd:COG3055   82 ANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWD------DGGNVA--------WVEVYDPATG 147

                        170       180       190
                 ....*....|....*....|....*....|
gi 148539936 396 EWLQLKE-NTSKSGpnLTCTLHNDG-IYIM 423
Cdd:COG3055  148 TWTQLAPlPTPRDH--LAAAVLPDGkILVI 175
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-104 2.48e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 81.00  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  14 DKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSIL- 92
Cdd:cd18239   34 DETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLd 113

                         90
                 ....*....|....*
gi 148539936  93 ---KLLLSEIKQENC 104
Cdd:cd18239  114 fckVLLISGVTLENC 128
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 10-86 1.70e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 76.94  E-value: 1.70e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFL 86
Cdd:cd01165    3 LVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-87 1.04e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 72.07  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   6 QIIEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASF 85
Cdd:cd18320    2 QKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNGEEILQAIECAAF 81


                 ..
gi 148539936  86 LQ 87
Cdd:cd18320   82 LQ 83
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-86 1.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 71.82  E-value: 1.12e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFL 86
Cdd:cd18186    4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-104 2.27e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 72.91  E-value: 2.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  21 KSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKL----LL 96
Cdd:cd18264   44 RSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLcsqyLI 123


                 ....*...
gi 148539936  97 SEIKQENC 104
Cdd:cd18264  124 NNLAPENC 131
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-108 2.77e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 72.34  E-value: 2.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18270   29 IVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQ 108

                         90       100
                 ....*....|....*....|....*
gi 148539936  88 VTSILKL----LLSEIKQENCVELF 108
Cdd:cd18270  109 VEDVLQRcreyLIKKINAENCVRLL 133
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-107 6.29e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 71.53  E-value: 6.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18244   33 VTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQ 112

                         90       100
                 ....*....|....*....|....
gi 148539936  88 VTSILK----LLLSEIKQENCVEL 107
Cdd:cd18244  113 LTEVVKfccsFLLAKICLDNCAEI 136
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-105 7.92e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 68.20  E-value: 7.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18256   23 VQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQ 102

                         90       100
                 ....*....|....*....|..
gi 148539936  88 VTSILKL----LLSEIKQENCV 105
Cdd:cd18256  103 LTEVVEIccefLKGQLHPSNCI 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 8-101 1.45e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 1.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936     8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                           90
                   ....*....|....
gi 148539936    88 VTSILKLLLSEIKQ 101
Cdd:smart00225  82 IPGLVELCEEFLLK 95
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-105 2.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 66.55  E-value: 2.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   1 MTSPEQIIEIVMD---DKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLE 77
Cdd:cd18274   16 MYDEGQLTDIVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQ 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 148539936  78 DLIETASFLQVTSI----LKLLLSEIKQENCV 105
Cdd:cd18274   96 ALFTAASIFQIPSLqdqcAQFMISRLDPQNSI 127
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-104 6.37e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 65.54  E-value: 6.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILK----LLLSEIKQEN 103
Cdd:cd18242   44 SDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQacceFLESQLDPSN 123


                 .
gi 148539936 104 C 104
Cdd:cd18242  124 C 124
PHA02713 PHA02713
hypothetical protein; Provisional
 199-361 6.80e-13

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 70.81  E-value: 6.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 199 SNLPQDMINvrgYGSAVLDNYLFIVGGYRMTSQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGGH---- 274
Cdd:PHA02713 288 STIPNHIIN---YASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQngtn 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 275 CLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGG------YTS--------KDRNTN----VLRYCPASDAW 336
Cdd:PHA02713 365 VERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidYTSvhhmnsidMEEDTHssnkVIRYDTVNNIW 444

                        170       180
                 ....*....|....*....|....*
gi 148539936 337 SVFHSCSAHVRKQQMLSVEDTIYLV 361
Cdd:PHA02713 445 ETLPNFWTGTIRPGVVSHKDDIYVV 469
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
183-319 7.61e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 7.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 183 SMLRYGEVEQRWKPLASnLPQdmiNVRGYGSAVL-DNYLFIVGGYRmtsqeisaahcYNPSKNEWNQVASLNQKRSNFKL 261
Cdd:COG3055  138 WVEVYDPATGTWTQLAP-LPT---PRDHLAAAVLpDGKILVIGGRN-----------GSGFSNTWTTLAPLPTARAGHAA 202

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 262 LAVSGKLYAVGG--HCLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGGYTS 319
Cdd:COG3055  203 AVLGGKILVFGGesGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETK 262
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-107 7.92e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 62.54  E-value: 7.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18271   29 IIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVS 108

                         90       100
                 ....*....|....*....|..
gi 148539936  90 SILK----LLLSEIKQENCVEL 107
Cdd:cd18271  109 LLSKacsdFLIKSIDLTNCLQL 130
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-133 7.92e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 62.31  E-value: 7.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18238   18 VTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQ 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148539936  88 VTsilklllseikqencvelfklsevygmhELRRACLKFMSCYYHP 133
Cdd:cd18238   98 VE----------------------------EVAKACCEFMKDHLHP 115
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 10-101 1.72e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 60.73  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVqVDNETLEDLIETASFLQVT 89
Cdd:pfam00651  15 LVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIP 93

                          90
                  ....*....|..
gi 148539936   90 SILKLLLSEIKQ 101
Cdd:pfam00651  94 SLVDKCEEFLIK 105
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-102 2.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 61.52  E-value: 2.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18261   31 ITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQ 110

                         90
                 ....*....|....*
gi 148539936  88 VTSILKLLLSEIKQE 102
Cdd:cd18261  111 LLELLSLCSHYLIQE 125
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-105 8.94e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 58.53  E-value: 8.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILK----LLLSEIKQEN 103
Cdd:cd18234   24 SDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEaccgFLMKQLHPSN 103


                 ..
gi 148539936 104 CV 105
Cdd:cd18234  104 CL 105
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-104 1.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 58.49  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18240   22 IRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIM 101

                         90
                 ....*....|....*....
gi 148539936  90 SILKL----LLSEIKQENC 104
Cdd:cd18240  102 GIVKAccdfLEDQLCPENC 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-111 2.67e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 58.36  E-value: 2.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18266   28 VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQ 107

                         90       100
                 ....*....|....*....|....*...
gi 148539936  88 VTSIL----KLLLSEIKQENCVELFKLS 111
Cdd:cd18266  108 IWKVVdfccEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-91 6.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 56.70  E-value: 6.08e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148539936  24 LIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSI 91
Cdd:cd18250   40 LAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSV 107
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-104 1.75e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 55.61  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18253   23 ICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQIS 102

                         90
                 ....*....|....*....
gi 148539936  90 SIL----KLLLSEIKQENC 104
Cdd:cd18253  103 PLRdacaKFLEEQLDPCNC 121
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-81 2.30e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 54.94  E-value: 2.30e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIE 81
Cdd:cd18287   25 VTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTDLKEDVLLD 98
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-109 2.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 54.98  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  13 DDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSIl 92
Cdd:cd18247   27 GDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSV- 105

                         90
                 ....*....|....*..
gi 148539936  93 klllseikQENCVELFK 109
Cdd:cd18247  106 --------KDACCEFLK 114
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-102 3.60e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 54.43  E-value: 3.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18263   16 VQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLQ 95

                         90
                 ....*....|....*
gi 148539936  88 VTSILKLLLSEIKQE 102
Cdd:cd18263   96 ISGALALCLDFLQRE 110
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-105 6.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 54.25  E-value: 6.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  14 DKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPG-LELVLEFINTSKVQVDNETLEDLIETASFLQVTSI- 91
Cdd:cd18254   31 NRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEvLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVr 110

                         90
                 ....*....|....*..
gi 148539936  92 ---LKLLLSEIKQENCV 105
Cdd:cd18254  111 daaAEFLEKNLYPSNCL 127
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-133 7.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 54.01  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQvdnetledlietasflq 87
Cdd:cd18265   26 VVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLR----------------- 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148539936  88 vtsilklllseIKQENCVELFKLSEVYGMHELRRACLKFMSCYYHP 133
Cdd:cd18265   89 -----------IQEDNVESVLEASDLLQVSKLREACVRFLEGQLHP 123
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-91 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 52.82  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18235   26 LVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLT 105


                 ..
gi 148539936  90 SI 91
Cdd:cd18235  106 DV 107
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-105 1.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 52.74  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKL----LLSEIKQEN 103
Cdd:cd18336   42 SDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVccnfLMKQLHPSN 121


                 ..
gi 148539936 104 CV 105
Cdd:cd18336  122 CL 123
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-107 2.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 51.72  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   4 PEQIIEIvmDDKTYNVSKSKLIEKSDYFRALYSsgmresaEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETA 83
Cdd:cd18275    5 PDLVIEV--SGQRIRAHKSVLAAKSDYFRARLS-------RDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGA 75

                         90       100
                 ....*....|....*....|....*...
gi 148539936  84 SFLQ----VTSILKLLLSEIKQENCVEL 107
Cdd:cd18275   76 RFLQmpcaAQCAVDAVRAQLCLGNCYEV 103
Kelch smart00612
Kelch domain;
267-309 3.07e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 3.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 148539936   267 KLYAVGGH----CLGTVECYSPEQDWWTCVAPLPDPLAEFSACECQG 309
Cdd:smart00612   1 KIYVVGGFdggqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-107 5.71e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 51.32  E-value: 5.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18268   28 LCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYP 107

                         90       100
                 ....*....|....*....|..
gi 148539936  90 SIL----KLLLSEIKQENCVEL 107
Cdd:cd18268  108 KLFeacsLYLQDQLTPENCLSM 129
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-103 1.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 50.59  E-value: 1.14e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539936  29 DYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKL----LLSEIKQEN 103
Cdd:cd18251   47 DYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFccdfLMSWVDNEN 125
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-93 2.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 49.16  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  11 VMDDKTYNVSKSKLIEKSDYFRALYSSgmresAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTS 90
Cdd:cd18206   28 VVDGVDFKAHKAVLAACSEYFRMLFVD-----QKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQD 102


                 ...
gi 148539936  91 ILK 93
Cdd:cd18206  103 IVT 105
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-105 2.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 49.85  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  12 MDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ---- 87
Cdd:cd18236   31 VDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQflrm 110

                         90
                 ....*....|....*...
gi 148539936  88 VTSILKLLLSEIKQENCV 105
Cdd:cd18236  111 VDACASFLTEALHPENCV 128
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-105 2.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 49.79  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKL----LLSEIKQEN 103
Cdd:cd18237   44 SHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMcvdfLKEQLDASN 123


                 ..
gi 148539936 104 CV 105
Cdd:cd18237  124 CL 125
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-105 2.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 49.44  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  17 YNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILK--- 93
Cdd:cd18252   34 FHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKace 113

                         90
                 ....*....|...
gi 148539936  94 -LLLSEIKQENCV 105
Cdd:cd18252  114 qFLVRHLDIDNCL 126
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-93 3.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.02  E-value: 3.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMrESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18212   26 ITLIVENVQFRAHKALLAASSEYFSMMFADEG-EVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFLK 104


                 ....*.
gi 148539936  88 VTSILK 93
Cdd:cd18212  105 VNDLVK 110
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-108 3.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 49.06  E-value: 3.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKLLLSEIKQE----N 103
Cdd:cd18340   50 SPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRlclsN 129


                 ....*
gi 148539936 104 CVELF 108
Cdd:cd18340  130 CLAIF 134
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 256-296 4.77e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 4.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148539936  256 RSNFKLLAVSGKLYAVGGH----CLGTVECYSPEQDWWTCVAPLP 296
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFdgnqSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-133 5.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 48.53  E-value: 5.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18338   24 VTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQ 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148539936  88 vtsilklllseikqencvelfklsevygMHELRRACLKFMSCYYHP 133
Cdd:cd18338  104 ----------------------------LQDVKKTCCEFLESQLHP 121
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 10-94 6.50e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 47.34  E-value: 6.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18314   11 LCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVP 90


                 ....*
gi 148539936  90 SILKL 94
Cdd:cd18314   91 DLEKL 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 209-253 6.73e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.68  E-value: 6.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148539936  209 RGYGSAVLDNYLFIVGGYRMtSQEISAAHCYNPSKNEWNQVASLN 253
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-91 7.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 48.83  E-value: 7.02e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539936  14 DKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPG-LELVLEFINTSKVQVDNETLEDLIETASFLQVTSI 91
Cdd:cd18267   49 NRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDSIHPEvLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDI 127
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-93 1.80e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 46.99  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  14 DKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILK 93
Cdd:cd18248   34 KEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVK 113
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-98 2.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 46.18  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAED--SVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18245   19 LVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLL 98

                         90
                 ....*....|.
gi 148539936  88 VTSiLKLLLSE 98
Cdd:cd18245   99 MTD-LKDLCCE 108
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 8-106 2.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 45.93  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18352   16 VTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYL 95

                         90
                 ....*....|....*....
gi 148539936  88 VTSILKLLLSEIKQENCVE 106
Cdd:cd18352   96 LEGLKRLCEYTIAQDLTLE 114
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-100 6.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 45.44  E-value: 6.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSV-RLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQV 88
Cdd:cd18230   26 IIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQM 105

                         90
                 ....*....|..
gi 148539936  89 TSILKLLLSEIK 100
Cdd:cd18230  106 TDIVQACHNFIK 117
Kelch smart00612
Kelch domain;
220-266 7.53e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 7.53e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 148539936   220 LFIVGGYrMTSQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSG 266
Cdd:smart00612   2 IYVVGGF-DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-105 9.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 45.05  E-value: 9.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18337   28 LVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLS 107

                         90       100
                 ....*....|....*....|
gi 148539936  90 SIL----KLLLSEIKQENCV 105
Cdd:cd18337  108 QVVeaccKFLMKQLHPSNCL 127
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-109 9.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 45.03  E-value: 9.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSgmresaeDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18243   35 VTLTAQGQQFHCHKAVLASCSQYFRSLFSI-------NNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILH 107

                         90       100
                 ....*....|....*....|..
gi 148539936  88 VTSILKLLLSEIKQENCVELFK 109
Cdd:cd18243  108 IPQVTKLCVQFLNDQISVQNYK 129
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 102-143 1.35e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 42.26  E-value: 1.35e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 148539936 102 ENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRML 143
Cdd:cd14733    3 ENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLEL 44
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-106 2.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 44.26  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMREsaEDSVRLRG--LSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18324   28 VLVGDAQFRAHRAVLASCSMYFHLFYKDQLDK--RDIVHLNSdiVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLH 105

                         90
                 ....*....|....*....
gi 148539936  88 VTSILKLLLSEIKQENCVE 106
Cdd:cd18324  106 MYDIVKVCKKKLKEKATTE 124
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-93 2.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 43.56  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18339   24 VTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQ 103


                 ....*.
gi 148539936  88 VTSILK 93
Cdd:cd18339  104 LMDVRQ 109
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-106 2.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 43.42  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  15 KTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQ---VDNETLEDLIETASFLQVTSI 91
Cdd:cd18297   22 RPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALELLRAASFFQLDGL 101

                         90
                 ....*....|....*
gi 148539936  92 LKLLLSEIKQENCVE 106
Cdd:cd18297  102 KRHCEILLSQQIDLD 116
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-105 3.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 43.42  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDS---VRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETAS 84
Cdd:cd18258   20 LKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAAN 99

                         90       100
                 ....*....|....*....|....*
gi 148539936  85 FLQVTSILKLLLSEIKQE----NCV 105
Cdd:cd18258  100 KFQFHTFCKVCVSFLEKQltasNCL 124
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-107 6.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 42.96  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18272   35 VTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQ 114

                         90       100
                 ....*....|....*....|....
gi 148539936  88 VTSIL----KLLLSEIKQENCVEL 107
Cdd:cd18272  115 LTALFeecsRFLARTVQVRNCLQV 138
Kelch_3 pfam13415
Galactose oxidase, central domain;
217-264 1.14e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 148539936  217 DNYLFIVGGYRMTSQE-ISAAHCYNPSKNEWNQVASLNQKRSNFKLLAV 264
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-91 1.28e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 41.45  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGmRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18231   19 IVLVRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQ 97


                 ....
gi 148539936  88 VTSI 91
Cdd:cd18231   98 MNDI 101
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 8-90 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 41.16  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSgMRESAEDSVRLRGL--SAPGLELVLEFINTSKVQVDNETLEDLIETASF 85
Cdd:cd18312   12 ITVRVGNTTFHLHKFPLCSKSGYFKRLASS-SSESDPSEIELNDFpgGAEAFELVAKFCYGMPINLTATNVVGLRCAAEY 90


                 ....*
gi 148539936  86 LQVTS 90
Cdd:cd18312   91 LEMTE 95
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-92 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 41.35  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAED-SVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQV 88
Cdd:cd18329   26 ILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPtVATFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAASYLQM 105


                 ....
gi 148539936  89 TSIL 92
Cdd:cd18329  106 TDVI 109
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-103 1.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 41.49  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  14 DKTYNVSKSKLIEKSDYFRALYSSGMRESAED-SVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSIL 92
Cdd:cd18207   36 EESFPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVI 115

                         90
                 ....*....|.
gi 148539936  93 KLLLSEIKQEN 103
Cdd:cd18207  116 DICQEVIKQSN 126
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-95 1.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 41.35  E-value: 1.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  28 SDYFRALYSSgmRESAEDSVRLRG--LSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKLL 95
Cdd:cd18194   46 SMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-91 2.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 41.07  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVT 89
Cdd:cd18326   30 ILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIP 109


                 ..
gi 148539936  90 SI 91
Cdd:cd18326  110 AV 111
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 298-338 2.54e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148539936  298 PLAEFSACECQGMIYVMGGYTSKDRNTNVLRYCPASDAWSV 338
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-127 2.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 40.31  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  24 LIEKSDYFRALYSSG-MRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETAsflqvtsilklllseikqe 102
Cdd:cd18294   35 LAARCEVFRAMFLTGpQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAA------------------- 95

                         90       100
                 ....*....|....*....|....*
gi 148539936 103 ncVElfklsevYGMHELRRACLKFM 127
Cdd:cd18294   96 --VE-------YGLDELRKLCERFI 111
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-106 2.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 40.69  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALyssgMRESAEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18354   23 LKFLVDGKYIYVHKVLLKIRCEHFRSL----LNENEEEIIEMSQFSYPVYRAFLEYLYTDSISLSPEDAIGLLDLATFYR 98

                         90
                 ....*....|....*....
gi 148539936  88 VTSILKLLLSEIKQENCVE 106
Cdd:cd18354   99 ENRLKKLCQQTIKQGICEE 117
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-106 3.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 40.79  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMREsaEDSVRLRG--LSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQ 87
Cdd:cd18325   28 VLVGEAQFRAHRAVLASCSMYFHLFYRDQLDK--RDIVHLNSdiVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYLH 105

                         90       100
                 ....*....|....*....|
gi 148539936  88 VTSILKLLLSEIK-QENCVE 106
Cdd:cd18325  106 MYDIVKVCKGKLKdKELCSE 125
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-92 3.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 40.10  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSV-RLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQV 88
Cdd:cd18199   23 IIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASYLQM 102


                 ....
gi 148539936  89 TSIL 92
Cdd:cd18199  103 TDVI 106
Kelch_6 pfam13964
Kelch motif;
210-256 5.58e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 5.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 148539936  210 GYGSAVLDNYLFIVGGYRMTSQEISAAHCYNPSKNEWNQVASLNQKR 256
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-102 5.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 39.35  E-value: 5.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYssgmrESAEDSVRL---RGLSAPGLELVLEFINTSKVQVDNETLEDLIETAS 84
Cdd:cd18217   21 CTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFldqSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAAS 95

                         90
                 ....*....|....*...
gi 148539936  85 FLQVTSILKLLlsEIKQE 102
Cdd:cd18217   96 YLGMEEVVAKC--KIKME 111
Kelch_4 pfam13418
Galactose oxidase, central domain;
209-252 6.42e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148539936  209 RGYGSAVL--DNYLFIVGGYRMTSQEISAAHCYNPSKNEWNQVASL 252
Cdd:pfam13418   2 RAYHTSTSipDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-104 7.37e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 39.16  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQV-DNETLEDLIETASFL 86
Cdd:cd18286   20 ITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELLSLADMY 99

                         90
                 ....*....|....*...
gi 148539936  87 QVTSILKLLLSEIKQENC 104
Cdd:cd18286  100 GLDGLKDVVAYTLRRDYC 117
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-92 7.76e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 39.14  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  10 IVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSV-RLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQV 88
Cdd:cd18330   23 IIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTaSLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQM 102


                 ....
gi 148539936  89 TSIL 92
Cdd:cd18330  103 TDVV 106
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-102 9.42e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 38.76  E-value: 9.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  13 DDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDSVRLRGLSAPGLELVLEFINTSKVQV-DNETLEDLIETASFLQVTSI 91
Cdd:cd18300   17 EDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPIlEDGDCVGLIVLANRLCLPRL 96

                         90
                 ....*....|.
gi 148539936  92 LKLLLSEIKQE 102
Cdd:cd18300   97 VALCEQYIVKE 107
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-98 9.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 38.72  E-value: 9.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148539936  28 SDYFRALysSGMRESAEDSVRLRG-LSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKLLLSE 98
Cdd:cd18311   38 TDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQLEFEEKSYGKLLRTAKELNMTVLLKLLEAH 107
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-86 1.31e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 38.82  E-value: 1.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539936  13 DDKTYNVSKSKLIEKSDYFRALYSSGMRESAE-----DSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFL 86
Cdd:cd18296   25 EGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnngsiPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMY 103
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 102-164 1.43e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 37.36  E-value: 1.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148539936 102 ENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPE-FRMLAANVREQIRDIRL-KGTATLVA 164
Cdd:cd18484    4 GNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAvYGRLSGAERELILRRRLeAGRACLVV 68
PLN02193 PLN02193
nitrile-specifier protein
 187-273 2.31e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 40.32  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 187 YGEVEQRWkpLASNLPQDMINVRG-YGSAVLDNYLFIVGGYrmTSQEISAAHCYNPSKNEWNQVASLNQK---RSNFKLL 262
Cdd:PLN02193 299 YNIVDKKW--FHCSTPGDSFSIRGgAGLEVVQGKVWVVYGF--NGCEVDDVHYYDPVQDKWTQVETFGVRpseRSVFASA 374

                         90
                 ....*....|.
gi 148539936 263 AVSGKLYAVGG 273
Cdd:PLN02193 375 AVGKHIVIFGG 385
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-100 3.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 37.63  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936   8 IEIVMDDKTYNVSKSKLIEKSDYFRALYSSGMRESAEDS--VRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASF 85
Cdd:cd18201   24 VNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvTHLDVVAVQGFSVILDFMYSGNLVLTSQNAIEVMSVASY 103

                         90
                 ....*....|....*
gi 148539936  86 LQVTSILKLLLSEIK 100
Cdd:cd18201  104 LQMTEVVQSCRNFIK 118
PHA02790 PHA02790
Kelch-like protein; Provisional
 220-362 4.13e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 39.64  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 220 LFIVGGYrMTSQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGGHCLGT-VECYSPEQDWWTCVAPLPDP 298
Cdd:PHA02790 274 VYLIGGW-MNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTsVERWFHGDAAWVNMPSLLKP 352

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148539936 299 LAEFSACECQGMIYVMGGYTSKDRNTNVLryCPASDAWSVFHSCSAHVRKQQMLSVEDTIYLVG 362
Cdd:PHA02790 353 RCNPAVASINNVIYVIGGHSETDTTTEYL--LPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 99-155 7.22e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 35.22  E-value: 7.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539936  99 IKQENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRML----AANVREQ--------IRDIR 155
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELvredAASVKNRqetdsipiIDDIR 69
PHA02790 PHA02790
Kelch-like protein; Provisional
 190-364 9.02e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 38.49  E-value: 9.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 190 VEQRWKPLASnlpqdMINVRGYGSAV-LDNYLFIVGGYRMTSQEISAAHcynpSKNEWNQVASLNQKRSNFKLLAVSGKL 268
Cdd:PHA02790 295 ISNNWIPIPP-----MNSPRLYASGVpANNKLYVVGGLPNPTSVERWFH----GDAAWVNMPSLLKPRCNPAVASINNVI 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936 269 YAVGGHCL--GTVECYSPEQDWWTCVAPLPDPLAEFSACECQGMIYVMGgytskdRNTNVlrYCPASDAWSVFHSCSAHV 346
Cdd:PHA02790 366 YVIGGHSEtdTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG------RNAEF--YCESSNTWTLIDDPIYPR 437

                        170
                 ....*....|....*...
gi 148539936 347 RKQQMLSVEDTIYLVGGY 364
Cdd:PHA02790 438 DNPELIIVDNKLLLIGGF 455
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 102-151 9.26e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 35.38  E-value: 9.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 148539936 102 ENCVELFKLSEVYGMHELRRACLKFMSCYYHPMLRRPEFRMLAANVREQI 151
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKI 53
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-100 9.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 36.02  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539936  17 YNVSKSKLIEKSDYFRALYSSGMRESaEDSVRLRGLSAPGLELVLEFINTSKVQVDNETLEDLIETASFLQVTSILKLLL 96
Cdd:cd18233   30 FKAHKNVLAAFSQYFRSLFQNSSSQK-NDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCY 108


                 ....
gi 148539936  97 SEIK 100
Cdd:cd18233  109 TFLK 112
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-84 9.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 35.18  E-value: 9.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148539936  20 SKSKLIEKSDYFRALYSSGMRESAEDSVRLR--GLSAPGLELVLEFINTSKVQ-VDNETLEDLIETAS 84
Cdd:cd18190   14 VRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLDlFSVENVHEVLELAS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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