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    bsg basigin [ Danio rerio (zebrafish) ]

    Gene ID: 337692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bsgprovided by ZNC
    Official Full Name
    basiginprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9638
    See related
    Ensembl:ENSDARG00000019881 AllianceGenome:ZFIN:ZDB-GENE-030131-9638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb26a05; wu:fo98e12
    Summary
    Predicted to be located in basolateral plasma membrane; endoplasmic reticulum membrane; and lateral plasma membrane. Is expressed in intestine and liver. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bsg in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (18929412..18946454)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (18904434..18921476)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene CACN subunit beta associated regulatory protein b Neighboring gene follistatin-like 3 (secreted glycoprotein) Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 2b Neighboring gene polymerase (RNA) mitochondrial (DNA directed)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Ochrietor JD, et al. Invest Ophthalmol Vis Sci, 2003 Sep. PMID 12939332
    2. Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages. Xie Y, et al. Front Immunol, 2021. PMID 34046029, Free PMC Article
    3. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Eichner R, et al. Nat Med, 2016 Jul. PMID 27294876
    4. The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Oehlers SH, et al. Dis Model Mech, 2011 Nov. PMID 21729873, Free PMC Article
    5. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    basigin
    Names
    5A11/Basigin-2
    cd147

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312882.1 → NP_001299811.1  basigin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BX664631, DT058336, EH520368, EH536274, EH563077
      UniProtKB/TrEMBL
      A4JYP7, Q6PH44
      Related
      ENSDARP00000139566.1, ENSDART00000161598.2
      Conserved Domains (2) summary
      smart00410
      Location:118 → 209
      IG_like; Immunoglobulin like
      cl11960
      Location:111 → 199
      Ig; Immunoglobulin domain

    2. NM_198142.2 → NP_937785.2  basigin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX664631, CK356411, DT058336, EH520368, EH536274, EH563077
      UniProtKB/TrEMBL
      A0A0R4ICR8, A0A8M1PDN1
      Related
      ENSDARP00000130496.1, ENSDART00000166650.3
      Conserved Domains (2) summary
      smart00410
      Location:235 → 326
      IG_like; Immunoglobulin like
      cl11960
      Location:38 → 114
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      18929412..18946454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296228.4 → XP_009294503.1  basigin isoform X1

      UniProtKB/TrEMBL
      A0A8M3AUM8
      Conserved Domains (2) summary
      smart00410
      Location:235 → 326
      IG_like; Immunoglobulin like
      cl11960
      Location:38 → 114
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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