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Conserved domains on  [gi|919184245|ref|NP_001299811|]
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basigin isoform 2 precursor [Danio rerio]

Protein Classification

Ig and IG_like domain-containing protein( domain architecture ID 11515198)

Ig and IG_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
118-209 6.59e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 6.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245   118 SSENANEKDKAVLSCGSQGYPSPTdWSWFKLPdagertPIFNGTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSE 197
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPE-VTWYKQG------GKLLAESGRFSVSRSGSTSTLTISNVTP-EDSGTYTCAATNS 73
                           90
                   ....*....|..
gi 919184245   198 VGTGTDDIQLRV 209
Cdd:smart00410  74 SGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
39-94 1.14e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


:

Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  39 ATLSCNLTNPSSP-IKghyWVKNGKKIEESYSTNTDSYAEHF---IEKADYHHSGIYTCV 94
Cdd:cd00096    1 VTLTCSASGNPPPtIT---WYKNGKPLPPSSRDSRRSELGNGtltISNVTLEDSGTYTCV 57
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
118-209 6.59e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 6.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245   118 SSENANEKDKAVLSCGSQGYPSPTdWSWFKLPdagertPIFNGTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSE 197
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPE-VTWYKQG------GKLLAESGRFSVSRSGSTSTLTISNVTP-EDSGTYTCAATNS 73
                           90
                   ....*....|..
gi 919184245   198 VGTGTDDIQLRV 209
Cdd:smart00410  74 SGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
111-195 1.36e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 45.25  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  111 PHIKASKSSENANEKDKAVLSCGSQGYPSPTdWSWFKlpdagERTPIFNGTDDKYEIKStpNKTTLYVKDLDInEDMGFY 190
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATGSPPPT-ITWYK-----NGEPISSGSTRSRSLSG--SNSTLTISNVTR-SDAGTY 72

                  ....*
gi 919184245  191 QCQGT 195
Cdd:pfam13927  73 TCVAS 77
IgI_NCAM-2 cd05870
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members ...
111-199 3.77e-06

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is organized similarly to NCAM, including five N-terminal Ig-like domains and two fibronectin type III domains. NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE), and may function like NCAM, as an adhesion molecule. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143278 [Multi-domain]  Cd Length: 98  Bit Score: 44.58  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 111 PHIKASKSsENANEKDKAVLSCGSQGYPSPtDWSWFKLPDA-----GERTPifngtDDKYEIKSTPNKTTLYVKDLDINe 185
Cdd:cd05870    3 PHIIQLKN-ETTVENGAATLSCKAEGEPIP-EITWKRASDGhtfseGDKSP-----DGRIEVKGQHGESSLHIKDVKLS- 74
                         90
                 ....*....|....
gi 919184245 186 DMGFYQCQGTSEVG 199
Cdd:cd05870   75 DSGRYDCEAASRIG 88
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
39-94 1.14e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  39 ATLSCNLTNPSSP-IKghyWVKNGKKIEESYSTNTDSYAEHF---IEKADYHHSGIYTCV 94
Cdd:cd00096    1 VTLTCSASGNPPPtIT---WYKNGKPLPPSSRDSRRSELGNGtltISNVTLEDSGTYTCV 57
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
38-108 1.49e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 1.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919184245    38 SATLSCNLTNPSSPIKghYWVKNGKK-------IEESYSTNTDSYaehFIEKADYHHSGIYTC-VFLTEPQANATIEVK 108
Cdd:smart00410  11 SVTLSCEASGSPPPEV--TWYKQGGKllaesgrFSVSRSGSTSTL---TISNVTPEDSGTYTCaATNSSGSASSGTTLT 84
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
29-94 2.03e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 2.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919184245   29 TSPEVNNATSATLSCNLTNPSSPIKghYWVKNGKKIEE---SYSTNTDSYAEHFIEKADYHHSGIYTCV 94
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGSPPPTI--TWYKNGEPISSgstRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
118-209 6.59e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 6.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245   118 SSENANEKDKAVLSCGSQGYPSPTdWSWFKLPdagertPIFNGTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSE 197
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPE-VTWYKQG------GKLLAESGRFSVSRSGSTSTLTISNVTP-EDSGTYTCAATNS 73
                           90
                   ....*....|..
gi 919184245   198 VGTGTDDIQLRV 209
Cdd:smart00410  74 SGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
111-195 1.36e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 45.25  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  111 PHIKASKSSENANEKDKAVLSCGSQGYPSPTdWSWFKlpdagERTPIFNGTDDKYEIKStpNKTTLYVKDLDInEDMGFY 190
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATGSPPPT-ITWYK-----NGEPISSGSTRSRSLSG--SNSTLTISNVTR-SDAGTY 72

                  ....*
gi 919184245  191 QCQGT 195
Cdd:pfam13927  73 TCVAS 77
IgI_NCAM-2 cd05870
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members ...
111-199 3.77e-06

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is organized similarly to NCAM, including five N-terminal Ig-like domains and two fibronectin type III domains. NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE), and may function like NCAM, as an adhesion molecule. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143278 [Multi-domain]  Cd Length: 98  Bit Score: 44.58  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 111 PHIKASKSsENANEKDKAVLSCGSQGYPSPtDWSWFKLPDA-----GERTPifngtDDKYEIKSTPNKTTLYVKDLDINe 185
Cdd:cd05870    3 PHIIQLKN-ETTVENGAATLSCKAEGEPIP-EITWKRASDGhtfseGDKSP-----DGRIEVKGQHGESSLHIKDVKLS- 74
                         90
                 ....*....|....
gi 919184245 186 DMGFYQCQGTSEVG 199
Cdd:cd05870   75 DSGRYDCEAASRIG 88
I-set pfam07679
Immunoglobulin I-set domain;
122-209 4.69e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 44.17  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  122 ANEKDKAVLSCGSQGYPSPTdWSWFKlpdAGERTPifngTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSEVGTG 201
Cdd:pfam07679  12 VQEGESARFTCTVTGTPDPE-VSWFK---DGQPLR----SSDRFKVTYEGGTYTLTISNVQP-DDSGKYTCVATNSAGEA 82

                  ....*...
gi 919184245  202 TDDIQLRV 209
Cdd:pfam07679  83 EASAELTV 90
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
111-199 5.28e-05

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 40.95  E-value: 5.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 111 PHIKASKSSEN--ANEKDKAVLSCGSQGYPSPtDWSWF---KLPDAGertpifngtDDKYEIKStpNKTTLYVKDLdINE 185
Cdd:cd20970    1 PVISTPQPSFTvtAREGENATFMCRAEGSPEP-EISWTrngNLIIEF---------NTRYIVRE--NGTTLTIRNI-RRS 67
                         90
                 ....*....|....
gi 919184245 186 DMGFYQCQGTSEVG 199
Cdd:cd20970   68 DMGIYLCIASNGVP 81
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
124-210 1.77e-04

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 39.71  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 124 EKDKAVLSCGSQGYPSPTdWSWFKlpdagERTPIFN-GTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSEVGTGT 202
Cdd:cd20951   14 EKSDAKLRVEVQGKPDPE-VKWYK-----NGVPIDPsSIPGKYKIESEYGVHVLHIRRVTV-EDSAVYSAVAKNIHGEAS 86

                 ....*...
gi 919184245 203 DDIQLRVR 210
Cdd:cd20951   87 SSASVVVE 94
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
110-212 5.75e-04

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 38.37  E-value: 5.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 110 LPHIKASKSSENA--NEKDKAVLSCGSQGYPSPTdWSWFKlpdAGErtPIFNGtDDKYEIKStpNKTTLYVKDLDiNEDM 187
Cdd:cd05730    1 PPTIRARQSEVNAtaNLGQSVTLACDADGFPEPT-MTWTK---DGE--PIESG-EEKYSFNE--DGSEMTILDVD-KLDE 70
                         90       100
                 ....*....|....*....|....*
gi 919184245 188 GFYQCQGTSEVGTGTDDIQLRVRSQ 212
Cdd:cd05730   71 AEYTCIAENKAGEQEAEIHLKVFAK 95
IgI_2_Follistatin_like cd05736
Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; ...
106-212 8.37e-04

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain found in human Follistatin-related protein 5 (FSTL5) and a follistatin-like molecule encoded by the CNS-related Mahya gene. Mahya genes have been retained in certain Bilaterian branches during evolution. They are conserved in Hymenoptera and Deuterostomes, but are absent from other metazoan species such as fruit fly and nematode. Mahya proteins are secretory, with a follistatin-like domain (Kazal-type serine/threonine protease inhibitor domain and EF-hand calcium-binding domain), two Ig-like domains, and a novel C-terminal domain. Mahya may be involved in learning and memory and in processing of sensory information in Hymenoptera and vertebrates. Follistatin is a secreted, multidomain protein that binds activins with high affinity and antagonizes their signaling.


Pssm-ID: 409399 [Multi-domain]  Cd Length: 93  Bit Score: 37.63  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245 106 EVKALPHIKASKSSENANekdkavLSCGSQGYPSPTdWSWFKlpdagertpifNGTD------DKYEIKStpNKTTLYVK 179
Cdd:cd05736    2 VIRVYPEFQAKEPGVEAS------LRCHAEGIPLPR-VQWLK-----------NGMDinpklsKQLTLIA--NGSELHIS 61
                         90       100       110
                 ....*....|....*....|....*....|...
gi 919184245 180 DLDInEDMGFYQCQGTSEVGTGTDDIQLRVRSQ 212
Cdd:cd05736   62 NVRY-EDTGAYTCIAKNEGGVDEDISSLFVEDS 93
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
128-200 8.83e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 8.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 919184245 128 AVLSCGSQGYPSPTdWSWFKlpdAGERTPifngTDDKYEIKSTPNKTTLYVKDLDInEDMGFYQCQGTSEVGT 200
Cdd:cd00096    1 VTLTCSASGNPPPT-ITWYK---NGKPLP----PSSRDSRRSELGNGTLTISNVTL-EDSGTYTCVASNSAGG 64
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
39-94 1.14e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 919184245  39 ATLSCNLTNPSSP-IKghyWVKNGKKIEESYSTNTDSYAEHF---IEKADYHHSGIYTCV 94
Cdd:cd00096    1 VTLTCSASGNPPPtIT---WYKNGKPLPPSSRDSRRSELGNGtltISNVTLEDSGTYTCV 57
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
38-108 1.49e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 1.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919184245    38 SATLSCNLTNPSSPIKghYWVKNGKK-------IEESYSTNTDSYaehFIEKADYHHSGIYTC-VFLTEPQANATIEVK 108
Cdd:smart00410  11 SVTLSCEASGSPPPEV--TWYKQGGKllaesgrFSVSRSGSTSTL---TISNVTPEDSGTYTCaATNSSGSASSGTTLT 84
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
29-94 2.03e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 2.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919184245   29 TSPEVNNATSATLSCNLTNPSSPIKghYWVKNGKKIEE---SYSTNTDSYAEHFIEKADYHHSGIYTCV 94
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGSPPPTI--TWYKNGEPISSgstRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
Ig_DSCAM cd05734
Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members ...
129-200 5.15e-03

Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members here are composed of the immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.


Pssm-ID: 409397 [Multi-domain]  Cd Length: 97  Bit Score: 35.55  E-value: 5.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919184245 129 VLSCGSQGYPSPT-DWSWFKLPDAGERTPI--FNGtddkyEIKSTPNkTTLYVKDLdINEDMGFYQCQGTSEVGT 200
Cdd:cd05734   20 VLNCSADGYPPPTiVWKHSKGSGVPQFQHIvpLNG-----RIQLLSN-GSLLIKHV-LEEDSGYYLCKVSNDVGA 87
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
29-99 6.60e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.25  E-value: 6.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919184245   29 TSPEVNNATSATLSCNLTNPSSPIKGHYWVKNGKKIEESY---STNTDSYAEHFIEKADYHHSGIYTCVFLTEP 99
Cdd:pfam00047   4 PTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIESLKvkhDNGRTTQSSLLISNVTKEDAGTYTCVVNNPG 77
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
38-93 8.40e-03

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 34.64  E-value: 8.40e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 919184245  38 SATLSCNLTNPSSPIKGhYWVKNGKKIEESYSTntdsyaeHFIEKADYHHSGIYTC 93
Cdd:cd05752   17 KVTLTCQGFYSPEQNST-QWYHNGTLISSTSSS-------YRIVAATVNDSGEYRC 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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