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    cdca9 cell division cycle associated 9 [ Danio rerio (zebrafish) ]

    Gene ID: 100151622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdca9provided by ZNC
    Official Full Name
    cell division cycle associated 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090706-4
    See related
    Ensembl:ENSDARG00000088639 AllianceGenome:ZFIN:ZDB-GENE-090706-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Dasra A; Dasra-A; cdca8.2
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to be located in nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in chromosome, centromeric region and spindle midzone. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cdca9 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (22674086..22678551)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (22552867..22557332)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:dkey-219e21.4 Neighboring gene zinc finger, CCHC domain containing 4 Neighboring gene uncharacterized LOC103911920 Neighboring gene actin binding LIM protein family, member 2 Neighboring gene uncharacterized LOC101883633 Neighboring gene actin filament associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation. Chen S, et al. Mol Cell Endocrinol, 2016 Sep 15. PMID 27267667
    2. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Sampath SC, et al. Cell, 2004 Jul 23. PMID 15260989
    3. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. Zhao XX, et al. J Biol Chem, 2016 Jan 1. PMID 26487724, Free PMC Article
    4. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    borealin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202426.1 → NP_001189355.1  borealin-2 isoform 1

      See identical proteins and their annotated locations for NP_001189355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BM036885, EH447881, EH549196
      UniProtKB/Swiss-Prot
      P86347
      UniProtKB/TrEMBL
      A0A8M1P3J8, F1QB27
      Related
      ENSDARP00000127103.1, ENSDART00000153254.3
      Conserved Domains (2) summary
      pfam10444
      Location:34 → 88
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:199 → 248
      Borealin; Cell division cycle-associated protein 8

    2. NM_001202427.1 → NP_001189356.1  borealin-2 isoform 1

      See identical proteins and their annotated locations for NP_001189356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BM036885, EH443933, EH541214
      UniProtKB/Swiss-Prot
      P86347
      UniProtKB/TrEMBL
      A0A8M1P3J8, F1QB27
      Related
      ENSDARP00000106626.1, ENSDART00000123808.4
      Conserved Domains (2) summary
      pfam10444
      Location:34 → 88
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:199 → 248
      Borealin; Cell division cycle-associated protein 8

    3. NM_001202428.1 → NP_001189357.1  borealin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BM036885, EH549196
      UniProtKB/Swiss-Prot
      P86347
      UniProtKB/TrEMBL
      A0A8M1NYY3, U3JAU5
      Related
      ENSDARP00000127364.1, ENSDART00000152930.2
      Conserved Domains (1) summary
      pfam10444
      Location:34 → 88
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      22674086..22678551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394840.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      79743..84239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86347.1 GenPept UniProtKB/Swiss-Prot:P86347

    Gene LinkOut

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