NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|320461702|ref|NP_001189357|]
View 

borealin-2 isoform 2 [Danio rerio]

Protein Classification

borealin N-terminal domain-containing protein( domain architecture ID 10564519)

borealin N-terminal domain-containing protein such as Danio rerio borealin-2 (also known as CDCA9/Dasra A) a component of the vertebrate chromosomal passenger complex (CPC) which regulates mitotic chromosome segregation, and Schizosaccharomyces pombe meiotically up-regulated gene 118 protein (Mug118) which plays a role in meiosis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 32-88 8.54e-12

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


:

Pssm-ID: 463095  Cd Length: 57  Bit Score: 58.73  E-value: 8.54e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320461702   32 RKELFIQQFEKEAQDRINEMEANLNKLLATVDRVFKIELMKMPLSLHTTLIKDLMND 88
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 32-88 8.54e-12

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 58.73  E-value: 8.54e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320461702   32 RKELFIQQFEKEAQDRINEMEANLNKLLATVDRVFKIELMKMPLSLHTTLIKDLMND 88
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 32-88 8.54e-12

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 58.73  E-value: 8.54e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320461702   32 RKELFIQQFEKEAQDRINEMEANLNKLLATVDRVFKIELMKMPLSLHTTLIKDLMND 88
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH