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    Rps6 ribosomal protein S6 [ Mus musculus (house mouse) ]

    Gene ID: 20104, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rps6provided by MGI
    Official Full Name
    ribosomal protein S6provided by MGI
    Primary source
    MGI:MGI:98159
    See related
    Ensembl:ENSMUSG00000028495 AllianceGenome:MGI:98159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S6R
    Summary
    A structural constituent of ribosome. Involved in glucose homeostasis. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; T cell activation; and ribosome biogenesis. Located in dendrite; perinuclear region of cytoplasm; and ribosome. Part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and limb. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 484.2), CNS E11.5 (RPKM 432.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps6 in Genome Data Viewer
    Location:
    4 C4; 4 40.69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86772336..86775604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86854099..86857367, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7973 Neighboring gene DENN domain containing 4C Neighboring gene predicted gene 6521 Neighboring gene STARR-seq mESC enhancer starr_10700 Neighboring gene STARR-seq mESC enhancer starr_10701 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene alkaline ceramidase 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Neighboring gene STARR-seq mESC enhancer starr_10707 Neighboring gene cadherin-2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102571, MGC103209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables structural constituent of ribosome PubMed 
    enables structural constituent of ribosome  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response PubMed 
    involved_in TOR signaling  
    involved_in TOR signaling  
    acts_upstream_of_or_within activation-induced cell death of T cells PubMed 
    involved_in cellular response to ethanol  
    involved_in cytoplasmic translation  
    involved_in cytoplasmic translation  
    involved_in cytoplasmic translation PubMed 
    acts_upstream_of_or_within erythrocyte development PubMed 
    acts_upstream_of_or_within gastrulation PubMed 
    acts_upstream_of_or_within gastrulation PubMed 
    involved_in glucose homeostasis PubMed 
    acts_upstream_of_or_within mammalian oogenesis stage PubMed 
    acts_upstream_of_or_within mitotic cell cycle PubMed 
    acts_upstream_of_or_within mitotic cell cycle checkpoint signaling PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of bicellular tight junction assembly  
    acts_upstream_of_or_within placenta development PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within rRNA processing PubMed 
    involved_in rRNA processing  
    involved_in response to insulin  
    involved_in ribosomal small subunit assembly  
    acts_upstream_of_or_within ribosomal small subunit biogenesis PubMed 
    involved_in ribosomal small subunit biogenesis  
    involved_in ribosomal small subunit biogenesis  
    Items 1 - 25 of 33
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in cell body  
    located_in cell body  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytosol  
    located_in cytosol  
    is_active_in cytosolic ribosome  
    located_in cytosolic ribosome  
    part_of cytosolic small ribosomal subunit PubMed 
    part_of cytosolic small ribosomal subunit  
    part_of cytosolic small ribosomal subunit PubMed 
    located_in dendrite PubMed 
    located_in dendrite  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in presynapse  
    part_of ribonucleoprotein complex PubMed 
    located_in ribosome PubMed 
    is_active_in ribosome  
    part_of small ribosomal subunit  
    part_of small-subunit processome  
    part_of small-subunit processome  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    small ribosomal subunit protein eS6
    Names
    40S ribosomal protein S6
    phosphoprotein NP33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009096.3NP_033122.1  small ribosomal subunit protein eS6

      See identical proteins and their annotated locations for NP_033122.1

      Status: PROVISIONAL

      Source sequence(s)
      AK146952
      Consensus CDS
      CCDS18310.1
      UniProtKB/Swiss-Prot
      P62754
      UniProtKB/TrEMBL
      Q3TL53, Q5BLK1
      Related
      ENSMUSP00000099878.5, ENSMUST00000102814.5
      Conserved Domains (1) summary
      cl00931
      Location:1215
      Ribosomal_S6e; Ribosomal protein S6e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86772336..86775604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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