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Dhx29 DExH-box helicase 29 [ Mus musculus (house mouse) ]

Gene ID: 218629, updated on 4-Jan-2025

Summary

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Official Symbol
Dhx29provided by MGI
Official Full Name
DExH-box helicase 29provided by MGI
Primary source
MGI:MGI:2145374
See related
Ensembl:ENSMUSG00000042426 AllianceGenome:MGI:2145374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddxx; 3732415M03; E130202M19Rik
Summary
Predicted to enable several functions, including nucleic acid binding activity; ribonucleoside triphosphate phosphatase activity; and ribosomal small subunit binding activity. Predicted to be involved in formation of translation preinitiation complex and ribosome assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Orthologous to human DHX29 (DExH-box helicase 29). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.2), CNS E18 (RPKM 5.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx29 in Genome Data Viewer
Location:
13 D2.2; 13 63.93 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113063976..113105968)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112927680..112969432)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene STARR-positive B cell enhancer ABC_E7290 Neighboring gene STARR-positive B cell enhancer ABC_E1469 Neighboring gene 40S ribosomal protein S13-like Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 
  • Transgenic (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation activator activity IEA
Inferred from Electronic Annotation
more info
  
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 43S preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 43S preinitiation complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
ATP-dependent RNA helicase Dhx29
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 29
DEAH box protein 29
nucleic acid helicase DDXx
NP_766182.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172594.3 → NP_766182.2  ATP-dependent RNA helicase Dhx29

    See identical proteins and their annotated locations for NP_766182.2

    Status: VALIDATED

    Source sequence(s)
    AK087450, BC038650, BC057112
    Consensus CDS
    CCDS26779.1
    UniProtKB/Swiss-Prot
    Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9
    Related
    ENSMUSP00000035244.6, ENSMUST00000038574.7
    Conserved Domains (5) summary
    smart00487
    Location:577 → 763
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:1055 → 1136
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:588 → 735
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:863 → 984
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:1178 → 1298
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113063976..113105968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938025.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGC1.1 GenPept UniProtKB/Swiss-Prot:Q6PGC1

Gene LinkOut

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