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    Nlrc5 NLR family, CARD domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291861, updated on 9-Dec-2024

    Summary

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    Symbol
    Nlrc5provided by RGD
    Full Name
    NLR family, CARD domain containing 5provided by RGD
    Primary source
    RGD:1309166
    See related
    EnsemblRapid:ENSRNOG00000048222 AllianceGenome:RGD:1309166
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cpne2
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including innate immune response; regulation of cytokine-mediated signaling pathway; and regulation of macromolecule biosynthetic process. Predicted to act upstream of or within response to bacterium. Predicted to be located in centrosome; cytosol; and nucleus. Orthologous to human NLRC5 (NLR family CARD domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 83.8), Thymus (RPKM 74.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nlrc5 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10483601..10587223, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10477638..10581023, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10904381..11006202, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483687 Neighboring gene copine 2 Neighboring gene uncharacterized LOC134483689 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC134483688 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1 Neighboring gene uncharacterized LOC102553339 Neighboring gene uncharacterized LOC120098571 Neighboring gene solute carrier family 12 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. Liu YR, et al. J Cell Physiol, 2019 Aug. PMID 30644097
    2. NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Liu YR, et al. Mol Immunol, 2017 Nov. PMID 28865311
    3. NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway. Zhou H, et al. Mol Med Rep, 2017 Sep. PMID 28713900
    4. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. Kuenzel S, et al. J Immunol, 2010 Feb 15. PMID 20061403
    5. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway. Li L, et al. J Recept Signal Transduct Res, 2021 Feb. PMID 32605461

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
      Title: NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
    2. The level of MEG3 significantly reduced in CFA-induced synovial tissues and Fibroblast-like synoviocytes (FLSs), whereas the NLRC5 levels were increased. Enforced expression of MEG3 may be responsible for the decreased level of NLRC5 and inflammatory cytokine level
      Title: Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5.
    3. NLRC5 silencing ameliorated cardiac fibrosis by inhibiting the TGFbeta1/Smad3 signaling pathway.
      Title: NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway.
    4. These results suggested that NLRC5 promotes Rheumatoid arthritis progression via the NF-kappaB signaling pathway potentially.
      Title: NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NLR family, CARD domain containing 5; protein NLRC5
    Names
    copine II
    protein NLRC5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10483601..10587223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098152.2 → XP_038954080.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_039098155.2 → XP_038954083.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_039098156.2 → XP_038954084.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_039098158.2 → XP_038954086.1  protein NLRC5 isoform X3

      Related
      ENSRNOP00000107072.1, ENSRNOT00000160769.1
      Conserved Domains (6) summary
      sd00033
      Location:1470 → 1497
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1386 → 1410
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1441 → 1751
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. XM_039098157.2 → XP_038954085.1  protein NLRC5 isoform X2

      Related
      ENSRNOP00000064308.4, ENSRNOT00000073239.4
      Conserved Domains (6) summary
      sd00033
      Location:1498 → 1525
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1414 → 1438
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1469 → 1779
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    6. XM_039098150.2 → XP_038954078.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    7. XM_039098154.2 → XP_038954082.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    8. XM_039098153.2 → XP_038954081.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    9. XM_063278888.1 → XP_063134958.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Related
      ENSRNOP00000111243.1, ENSRNOT00000142811.1

    10. XM_063278889.1 → XP_063134959.1  protein NLRC5 isoform X4

    RNA

    1. XR_005496893.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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