|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.69e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.69e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747941 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1502-1801 |
2.19e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1502 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1568
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1569 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1646
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1647 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1722
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 1723 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1801
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.24e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747941 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.09e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.26 E-value: 2.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747941 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
709-1022 |
1.47e-14 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 76.63 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 709 AEALCRSLPTMGSLKMLGLHDNQL--KDPEVLSLVDLIPCLRKLQKLDLSQNSFCmSTLLSSVKAAITCPTVRKLQVRES 786
Cdd:cd00116 40 AKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 787 ELifflspvPETATQQSGasdaqgeDSPKEGQSRNLQLRLQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRL 866
Cdd:cd00116 119 GL-------GDRGLRLLA-------KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 867 VTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHIS--LLTNTVVLTFAQELRdqegsfkrgaqltgfmsp 944
Cdd:cd00116 185 LAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdnNLTDAGAAALASALL------------------ 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 945 vtsELSQRSRRIRLTHCGFLAEHTEKLCEALRVSCQshpLDHLDLSDNFLKDKGVILLTQLLPRLGP-LKSLNLSRNDF 1022
Cdd:cd00116 247 ---SPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
956-1282 |
7.06e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 956 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1031
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1032 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1111
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1112 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1191
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1192 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1271
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747941 1272 SYPHIQEVSVS 1282
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.69e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.69e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747941 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1502-1801 |
2.19e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1502 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1568
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1569 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1646
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1647 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1722
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 1723 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1801
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.24e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747941 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1469-1779 |
4.16e-26 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 111.29 E-value: 4.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1469 ELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKED--TELLIGALQRTCRLKRLHLShlplETSSLDLLVQ 1546
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLS----DNALGPDGCG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1547 GLSNMTL---LQDLCLKHSQIGDMGTQHLA-AILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGD 1622
Cdd:cd00116 100 VLESLLRsssLQELKLNNNGLGDRGLRLLAkGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1623 PTALELAQRFP--PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEvslaennlaggvphfskrlpllkqINLVSCKIED 1700
Cdd:cd00116 180 AGIRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEV------------------------LNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1701 QAAKHLAT-NLTLCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLvHGSCVPVIRLWN 1779
Cdd:cd00116 236 AGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWV 314
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.09e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.26 E-value: 2.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747941 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
709-1022 |
1.47e-14 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 76.63 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 709 AEALCRSLPTMGSLKMLGLHDNQL--KDPEVLSLVDLIPCLRKLQKLDLSQNSFCmSTLLSSVKAAITCPTVRKLQVRES 786
Cdd:cd00116 40 AKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 787 ELifflspvPETATQQSGasdaqgeDSPKEGQSRNLQLRLQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRL 866
Cdd:cd00116 119 GL-------GDRGLRLLA-------KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 867 VTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHIS--LLTNTVVLTFAQELRdqegsfkrgaqltgfmsp 944
Cdd:cd00116 185 LAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdnNLTDAGAAALASALL------------------ 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 945 vtsELSQRSRRIRLTHCGFLAEHTEKLCEALRVSCQshpLDHLDLSDNFLKDKGVILLTQLLPRLGP-LKSLNLSRNDF 1022
Cdd:cd00116 247 ---SPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
836-1030 |
1.81e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.83 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 836 AKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISL--L 913
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVnrI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 914 TNTVVLTFAQELRdqegsfkRGAQLTgfmspvtsELSqrsrrirLTHCGFLAEHTEKLCEALrvscQSHP-LDHLDLSDN 992
Cdd:COG5238 305 GDEGAIALAEGLQ-------GNKTLH--------TLN-------LAYNGIGAQGAIALAKAL----QENTtLHSLDLSDN 358
|
170 180 190
....*....|....*....|....*....|....*...
gi 1958747941 993 FLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSL 1030
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
520-635 |
2.71e-07 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 51.14 E-value: 2.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 520 HLNLQEFFAALYLMASDTVDKDTLINYVTLNSHWVLRTKA-------KPGLSDHLPTFLAGLASHTCHTFLCHLaQQDEA 592
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESLKSLldkalksKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958747941 593 WVGSRQATvIQVLRKLASRKLTGPKMVELYHYVAETQDLELAR 635
Cdd:pfam17776 80 SSEIKQEL-LQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1461-1755 |
2.39e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.99 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1461 QNILISSCELKSFRLTFSNVSTESPAHLASGLEhchhleELDFSNNSLCKEdTELLIGALQrtcRLKRLHL------SHL 1534
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLE------TLDLSNNMLSGE-IPNDIGSFS---SLKVLDLggnvlvGKI 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1535 PLEtssldllvqgLSNMTLLQDLCLKHSQ--------IGDM--------GTQHLAAILP----RLPGLRKLDLS-GNRIG 1593
Cdd:PLN00113 181 PNS----------LTNLTSLEFLTLASNQlvgqipreLGQMkslkwiylGYNNLSGEIPyeigGLTSLNHLDLVyNNLTG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1594 PaggmqLVKSLTHFKNLEEIILGNNTLGDPtalelaqrFPP------QLRVLCLTSSHLGPEgalcLAQALEQCPHIEEV 1667
Cdd:PLN00113 251 P-----IPSSLGNLKNLQYLFLYQNKLSGP--------IPPsifslqKLISLDLSDNSLSGE----IPELVIQLQNLEIL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1668 SLAENNLAGGVPHFSKRLPLLKQINLVSCKIEDQAAKHLA--TNLT----------------LCPA--LEKLLLSWNHLG 1727
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGkhNNLTvldlstnnltgeipegLCSSgnLFKLILFSNSLE 393
|
330 340
....*....|....*....|....*...
gi 1958747941 1728 DEMAAELAQVlpqmGQLKRVDLEKNQIT 1755
Cdd:PLN00113 394 GEIPKSLGAC----RSLRRVRLQDNSFS 417
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1579-1606 |
2.43e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 2.43e-03
10 20
....*....|....*....|....*...
gi 1958747941 1579 LPGLRKLDLSGNRIGPAGGMQLVKSLTH 1606
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
956-1282 |
7.06e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 956 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1031
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1032 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1111
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1112 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1191
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1192 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1271
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747941 1272 SYPHIQEVSVS 1282
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.69e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.69e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1 MDAESYRLGNENLWAWLVELLSKKPEWLSAKVRFFLPTLDPDCSNEAPI-SEVTHHQLNRLFAQGPATWESFIYTLCIEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDpTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1958747941 80 EVPLSLEVPLLSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1502-1801 |
2.19e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 123.36 E-value: 2.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1502 DFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSS--LDLLVQGLSNMTLLQD-----------LCLKHSQIGDMG 1568
Cdd:COG5238 117 PDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMakalqnnsvetVYLGCNQIGDEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1569 TQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQ--RFPPQLRVLCLTSSHL 1646
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEalKNNTTVETLYLSGNQI 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1647 GPEGALCLAQALEQCPHIEEVSLAENNLAG-GVPHFSKRL---PLLKQINLVSCKIEDQAAKHLATNLTLCPALEKLLLS 1722
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDeGAIALAEGLqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 1723 WNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGScVPVIRLWNNPIPACVAQSLQSQEPRLDFSF 1801
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
224-387 |
4.24e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.09 E-value: 4.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDR-FQAVFLLEFRQLNMITQLLTLPQLLFDLYLSPEsDDADAVWQYLEENA 302
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPA-APVSEVWAVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEaLHTDSVGTDNAGSALTLFSELCHGDLLPGCWVMTTSRPG---KLPSCVPtEAAMVYMWGFDGLRVEK 379
Cdd:pfam05729 80 ERLLLILDGLDE-LVSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQ 157
|
....*...
gi 1958747941 380 YVTHFFSD 387
Cdd:pfam05729 158 YVRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1469-1779 |
4.16e-26 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 111.29 E-value: 4.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1469 ELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKED--TELLIGALQRTCRLKRLHLShlplETSSLDLLVQ 1546
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLS----DNALGPDGCG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1547 GLSNMTL---LQDLCLKHSQIGDMGTQHLA-AILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGD 1622
Cdd:cd00116 100 VLESLLRsssLQELKLNNNGLGDRGLRLLAkGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1623 PTALELAQRFP--PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEvslaennlaggvphfskrlpllkqINLVSCKIED 1700
Cdd:cd00116 180 AGIRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEV------------------------LNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1701 QAAKHLAT-NLTLCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLvHGSCVPVIRLWN 1779
Cdd:cd00116 236 AGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWV 314
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1397-1674 |
1.21e-22 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 100.89 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1397 WLQLEFPRQEdhseAMALRLAHCDLGTDHGLLMRQLVETCARLQQLSLSQVSF-SDDDGTRSrLLQNiLISSCelKSFRL 1475
Cdd:cd00116 15 ATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgRIPRGLQS-LLQG-LTKGC--GLQEL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1476 TFSNvsTESPAHLASGLEHCHH---LEELDFSNNSLCKEDTELLIGALQ-RTCRLKRLHLSHLPLETSSLDLLVQGLSNM 1551
Cdd:cd00116 87 DLSD--NALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLAKGLKdLPPALEKLVLGRNRLEGASCEALAKALRAN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1552 TLLQDLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQR 1631
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1958747941 1632 FP---PQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEVSLAENNL 1674
Cdd:cd00116 245 LLspnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
224-676 |
2.09e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 95.26 E-value: 2.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 224 RVTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAV-FLLEFRQLNMITQLLTLPQLLFDLYLSPesdDADAVWQYLEEna 302
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLAEEASLEDLLAEALEKRGGE---PEDALERLLRN-- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 303 HQILLIFDGLDEALhtDSVGTDNAGSALTLFSELChgdllPGCWVMTTSRPGKLPSCVPTEAAMVYMWGFDGLRVEKYVT 382
Cdd:COG5635 256 GRLLLLLDGLDEVP--DEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 383 HFFSDLLSQ-ELALKEMRANERLRGMCAIPALCRVACFCLRcsllsgsspgQSSALLPTITQLYLQMVKTF--------- 452
Cdd:COG5635 329 KWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR----------ERGELPDTRAELYEQFVELLlerwdeqrg 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 453 -SSSGTLSATSLLG-LGNVALRGLVTGKVIFSVED----IPPQLMALGAVHSLLTSFCIRT----RSGHKEigYAFVHLN 522
Cdd:COG5635 399 lTIYRELSREELRElLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRS 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 523 LQEFFAALYLMASDTVDKDTLINYVTLNSHW--VLRtkakpglsdhlptFLAGLAS--HTCHTFLCHLAQQDEAWVGSRQ 598
Cdd:COG5635 477 FQEYLAARALVEELDEELLELLAEHLEDPRWreVLL-------------LLAGLLDdvKQIKELIDALLARDDAAALALA 543
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747941 599 ATVIQVLRKLASRKLTGPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLDFD 676
Cdd:COG5635 544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALL 621
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1414-1659 |
3.13e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 92.55 E-value: 3.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1414 LRLAHCDLGTDHGLLMRQlvetcaRLQQLSLSQVSFSDD--DGTRSRLLQNILISSCELKSFRLTFSNVSTESPAHLASG 1491
Cdd:COG5238 158 LLGLAARLGLLAAISMAK------ALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1492 LEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDMGTQH 1571
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIA 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1572 LAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRF--PPQLRVLCLTSSHLGPE 1649
Cdd:COG5238 312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLegNTTLRELNLGKNNIGKQ 391
|
250
....*....|
gi 1958747941 1650 GALCLAQALE 1659
Cdd:COG5238 392 GAEALIDALQ 401
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1488-1667 |
5.99e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 91.78 E-value: 5.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1488 LASGLEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDM 1567
Cdd:COG5238 256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1568 GTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRF-PPQLRVLCLTSSHL 1646
Cdd:COG5238 336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALqTNRLHTLILDGNLI 415
|
170 180
....*....|....*....|.
gi 1958747941 1647 GPEGAlclAQALEQCPHIEEV 1667
Cdd:COG5238 416 GAEAQ---QRLEQLLERIKSV 433
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1556-1790 |
4.24e-17 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 84.33 E-value: 4.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1556 DLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGgMQLVKSLTHFKNLEEIILGNNTLGDpTALELAQR---- 1631
Cdd:cd00116 57 CLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkd 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1632 FPPQLRVLCLTSSHLGPEGALCLAQALEQCPHIEEVSLAENNlaggvphfskrlpllkqinlvsckIEDQAAKHLATNLT 1711
Cdd:cd00116 135 LPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNG------------------------IGDAGIRALAEGLK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1712 LCPALEKLLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGS-CVPVIRLWNNPIPACVAQSL 1790
Cdd:cd00116 191 ANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDL 270
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1459-1809 |
2.85e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 80.36 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1459 LLQNILISSCELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKEDTELLIGALQRTCRLKRLHLSHLplet 1538
Cdd:COG4886 31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1539 ssldllvQGLSNMTLLQDLCLKHSQIGDmgtqhLAAILPRLPGLRKLDLSGNRIGpaggmQLVKSLTHFKNLEEIILGNN 1618
Cdd:COG4886 107 -------EELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1619 TLGD-PTAL-ELaqrfpPQLRVLCLTSSHLGPegalcLAQALEQCPHIEEVSLAENNLAgGVPHFSKRLPLLKQINLVSC 1696
Cdd:COG4886 170 QLTDlPEELgNL-----TNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1697 KIEDqaakhlATNLTLCPALEKLLLSWNHLGDemaaelaqvLP---QMGQLKRVDLEKNQITACGAQLLAQGLVHGSCVP 1773
Cdd:COG4886 239 QLTD------LPELGNLTNLEELDLSNNQLTD---------LPplaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
|
330 340 350
....*....|....*....|....*....|....*.
gi 1958747941 1774 VIRLWNNPIPACVAQSLQSQEPRLDFSFFEQQPQTL 1809
Cdd:COG4886 304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1568-1793 |
2.89e-15 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 78.94 E-value: 2.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1568 GTQHLAAILPRLPGLRKLDLSGNRIGPAGGMQLVKSLTHFKNLEEIILG-NNTLGDPTALE-LAQRFP--PQLRVLCLTS 1643
Cdd:cd00116 11 KTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSlNETGRIPRGLQsLLQGLTkgCGLQELDLSD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1644 SHLGPEGALCLaQALEQCPHIEEVSLAENNLA-GGVPHFSKRL----PLLKQINLVSCKIEDQAAKHLATNLTLCPALEK 1718
Cdd:cd00116 91 NALGPDGCGVL-ESLLRSSSLQELKLNNNGLGdRGLRLLAKGLkdlpPALEKLVLGRNRLEGASCEALAKALRANRDLKE 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958747941 1719 LLLSWNHLGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGSCVPVIRLWNNPIPACVAQSLQSQ 1793
Cdd:cd00116 170 LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
709-1022 |
1.47e-14 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 76.63 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 709 AEALCRSLPTMGSLKMLGLHDNQL--KDPEVLSLVDLIPCLRKLQKLDLSQNSFCmSTLLSSVKAAITCPTVRKLQVRES 786
Cdd:cd00116 40 AKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 787 ELifflspvPETATQQSGasdaqgeDSPKEGQSRNLQLRLQKCQLRVHDAKALVELFQKGPRLEEVDLSGNHLKDEGCRL 866
Cdd:cd00116 119 GL-------GDRGLRLLA-------KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 867 VTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHIS--LLTNTVVLTFAQELRdqegsfkrgaqltgfmsp 944
Cdd:cd00116 185 LAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdnNLTDAGAAALASALL------------------ 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958747941 945 vtsELSQRSRRIRLTHCGFLAEHTEKLCEALRVSCQshpLDHLDLSDNFLKDKGVILLTQLLPRLGP-LKSLNLSRNDF 1022
Cdd:cd00116 247 ---SPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
836-1030 |
1.81e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.83 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 836 AKALVELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELHISL--L 913
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVnrI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 914 TNTVVLTFAQELRdqegsfkRGAQLTgfmspvtsELSqrsrrirLTHCGFLAEHTEKLCEALrvscQSHP-LDHLDLSDN 992
Cdd:COG5238 305 GDEGAIALAEGLQ-------GNKTLH--------TLN-------LAYNGIGAQGAIALAKAL----QENTtLHSLDLSDN 358
|
170 180 190
....*....|....*....|....*....|....*...
gi 1958747941 993 FLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSL 1030
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
822-1162 |
3.21e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 822 LQLRLQKCQLRVHDAKalvELFQKGPRLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQKLDLSDNglsQTGVtyLLKAVST 901
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLN---ETGR--IPRGLQS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 902 CGtleelhiSLLTNTVVLtfaQELRDQEGSFkrGAQLTGFMSPVTSELSQRSrrIRLTHCGFLAEHTEKLCEALRVScqS 981
Cdd:cd00116 73 LL-------QGLTKGCGL---QELDLSDNAL--GPDGCGVLESLLRSSSLQE--LKLNNNGLGDRGLRLLAKGLKDL--P 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 982 HPLDHLDLSDNFLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSLVLCMSSLQWLFHLevSLESDCIFLRGAGtsr 1061
Cdd:cd00116 137 PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVL--DLNNNGLTDEGAS--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1062 dALAGGPEFPAGAQLLELSQrctsrsfclqeCQLESLNLAYLCDALEKC-PGPLEIQLSCKSLNDDSLKTLLQRLPQIPQ 1140
Cdd:cd00116 212 -ALAETLASLKSLEVLNLGD-----------NNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKES 279
|
330 340
....*....|....*....|..
gi 1958747941 1141 LSQLRLTHTVLSSRSPFLLADI 1162
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAES 301
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
686-901 |
4.94e-12 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 70.20 E-value: 4.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 686 EALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKMLGLHDNQLKDPEVLSLVDLIPCLRKLQKLDLSQNSFCMSTL 765
Cdd:COG5238 202 EALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 766 LSSVKAAITCPTVRKLQVRESELifflspvpetatqqsgasDAQGEDSPKEGQSRNLQLR---LQKCQLRVHDAKALVEL 842
Cdd:COG5238 282 IALAKALQGNTTLTSLDLSVNRI------------------GDEGAIALAEGLQGNKTLHtlnLAYNGIGAQGAIALAKA 343
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958747941 843 FQKGPRLEEVDLSGNHLKDEGCRLVTKAV---SQLHiaqKLDLSDNGLSQTGVTYLLKAVST 901
Cdd:COG5238 344 LQENTTLHSLDLSDNQIGDEGAIALAKYLegnTTLR---ELNLGKNNIGKQGAEALIDALQT 402
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1438-1633 |
8.29e-12 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 8.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1438 RLQQLSLSQVSFSDDDgtrSRLLQNILISSCELKSFRLTFSNVSTESPAHLASGLEHCHHLEELDFSNNSLCKEDTELLI 1517
Cdd:COG5238 237 SLTTLDLSNNQIGDEG---VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1518 GALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCLKHSQIGDMGTQHLAAILPRLPGLRKLDLSGNRIGPAGG 1597
Cdd:COG5238 314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
170 180 190
....*....|....*....|....*....|....*.
gi 1958747941 1598 MQLVKSLTHfKNLEEIILGNNTLGDPTALELAQRFP 1633
Cdd:COG5238 394 EALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
520-635 |
2.71e-07 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 51.14 E-value: 2.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 520 HLNLQEFFAALYLMASDTVDKDTLINYVTLNSHWVLRTKA-------KPGLSDHLPTFLAGLASHTCHTFLCHLaQQDEA 592
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESLKSLldkalksKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958747941 593 WVGSRQATvIQVLRKLASRKLTGPKMVELYHYVAETQDLELAR 635
Cdd:pfam17776 80 SSEIKQEL-LQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1490-1592 |
3.29e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 52.87 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1490 SGLEHCHHLEELDFSNNSLCKEDT----ELLIGALQRTcrLKRLHLSHLPLETssldllVQGLSNMTLLQDLCLKHSQIG 1565
Cdd:cd21340 84 EGLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNS--LRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQIS 155
|
90 100
....*....|....*....|....*..
gi 1958747941 1566 DMgtQHLAAILPRLPGLRKLDLSGNRI 1592
Cdd:cd21340 156 DL--EELLDLLSSWPSLRELDLTGNPV 180
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1491-1642 |
3.25e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 50.17 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1491 GLEHCHHLEELDFSNNSLCKedtellIGALQRTCRLKRLHLSHLPLETssldllVQGLSNMTLLQDLCLKHSQIgDMGTQ 1570
Cdd:cd21340 41 NLEFLTNLTHLYLQNNQIEK------IENLENLVNLKKLYLGGNRISV------VEGLENLTNLEELHIENQRL-PPGEK 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958747941 1571 ------HLAAILPRlpgLRKLDLSGNRIgpaggmQLVKSLTHFKNLEEIILGNNTLGDPTALELAQRFPPQLRVLCLT 1642
Cdd:cd21340 108 ltfdprSLAALSNS---LRVLNISGNNI------DSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1576-1756 |
9.41e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 9.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1576 LPRLPGLRKLDLSGNRIGPAGGmqlvksLTHFKNLEEIILGNNtlgdptalelaqrfppQLRVLcltsshlgpEGalcla 1655
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN------LENLVNLKKLYLGGN----------------RISVV---------EG----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1656 qaLEQCPHIEEVSLAENNLAGGVP-HFSKR-----LPLLKQINLVSCKIEDqaakhlATNLTLCPALEKLLLSWNHLGDe 1729
Cdd:cd21340 86 --LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD- 156
|
170 180
....*....|....*....|....*..
gi 1958747941 1730 mAAELAQVLPQMGQLKRVDLEKNQITA 1756
Cdd:cd21340 157 -LEELLDLLSSWPSLRELDLTGNPVCK 182
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1461-1755 |
2.39e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.99 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1461 QNILISSCELKSFRLTFSNVSTESPAHLASGLEhchhleELDFSNNSLCKEdTELLIGALQrtcRLKRLHL------SHL 1534
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLE------TLDLSNNMLSGE-IPNDIGSFS---SLKVLDLggnvlvGKI 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1535 PLEtssldllvqgLSNMTLLQDLCLKHSQ--------IGDM--------GTQHLAAILP----RLPGLRKLDLS-GNRIG 1593
Cdd:PLN00113 181 PNS----------LTNLTSLEFLTLASNQlvgqipreLGQMkslkwiylGYNNLSGEIPyeigGLTSLNHLDLVyNNLTG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1594 PaggmqLVKSLTHFKNLEEIILGNNTLGDPtalelaqrFPP------QLRVLCLTSSHLGPEgalcLAQALEQCPHIEEV 1667
Cdd:PLN00113 251 P-----IPSSLGNLKNLQYLFLYQNKLSGP--------IPPsifslqKLISLDLSDNSLSGE----IPELVIQLQNLEIL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1668 SLAENNLAGGVPHFSKRLPLLKQINLVSCKIEDQAAKHLA--TNLT----------------LCPA--LEKLLLSWNHLG 1727
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGkhNNLTvldlstnnltgeipegLCSSgnLFKLILFSNSLE 393
|
330 340
....*....|....*....|....*...
gi 1958747941 1728 DEMAAELAQVlpqmGQLKRVDLEKNQIT 1755
Cdd:PLN00113 394 GEIPKSLGAC----RSLRRVRLQDNSFS 417
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
673-919 |
4.78e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.54 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 673 LDFDGCPLEpHCPEALVGCGQVENLSFKSRKCGDafaeaLCRSLPTMGSLKMLGLHDNQLKD-PEVLSLvdlipcLRKLQ 751
Cdd:COG4886 118 LDLSGNQLT-DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDlPEELGN------LTNLK 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 752 KLDLSQNSfcmstlLSSVKAAIT-CPTVRKLQVRESELIFFLSPVpetatqqsgasdaqgedspkeGQSRNLQ-LRLQKC 829
Cdd:COG4886 186 ELDLSNNQ------ITDLPEPLGnLTNLEELDLSGNQLTDLPEPL---------------------ANLTNLEtLDLSNN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 830 QLRvhDAKALVELfqkgPRLEEVDLSGNHLKDegcrlvTKAVSQLHIAQKLDLSDNGLSQTGVTYLLKAVSTCGTLEELH 909
Cdd:COG4886 239 QLT--DLPELGNL----TNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
250
....*....|
gi 1958747941 910 ISLLTNTVVL 919
Cdd:COG4886 307 LLNLLELLIL 316
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1498-1755 |
8.16e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.45 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1498 LEELDFSNNSLCKEDTELLIgalqrtcRLKRLHLSHL---------PLETSSLDLL--VQGLSNM---TLLQDLClKHSQ 1563
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVI-------QLQNLEILHLfsnnftgkiPVALTSLPRLqvLQLWSNKfsgEIPKNLG-KHNN 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1564 IG--DMGTQHLAAILPRL----PGLRKLDLSGNRIGPaggmQLVKSLTHFKNLEEIILGNNTLGDptalELAQRFP--PQ 1635
Cdd:PLN00113 358 LTvlDLSTNNLTGEIPEGlcssGNLFKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSG----ELPSEFTklPL 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1636 LRVLCLTSSHLGPEgalcLAQALEQCPHIEEVSLAENNLAGGVPHF--SKRL---------------------PLLKQIN 1692
Cdd:PLN00113 430 VYFLDISNNNLQGR----INSRKWDMPSLQMLSLARNKFFGGLPDSfgSKRLenldlsrnqfsgavprklgslSELMQLK 505
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958747941 1693 LVSCKIEDQAAKHLATnltlCPALEKLLLSWNHLGDEMAAELAQvLPQMGQLkrvDLEKNQIT 1755
Cdd:PLN00113 506 LSENKLSGEIPDELSS----CKKLVSLDLSHNQLSGQIPASFSE-MPVLSQL---DLSQNQLS 560
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1579-1606 |
2.43e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 2.43e-03
10 20
....*....|....*....|....*...
gi 1958747941 1579 LPGLRKLDLSGNRIGPAGGMQLVKSLTH 1606
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
956-1282 |
7.06e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 956 IRLTHCGFLAEHTEKLCEALRVScqsHPLDHLDLSDNFL--KDKGVILLTQLLPRLGPLKSLNLSRNDFSMD--AVFSLV 1031
Cdd:cd00116 28 LRLEGNTLGEEAAKALASALRPQ---PSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDgcGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1032 LCMSSLQwLFHLEVSLESDciflRGAGTSRDALaggpefpagaqlleLSQRCTSRSFCLQECQLESLNLAYLCDALEKCP 1111
Cdd:cd00116 105 LRSSSLQ-ELKLNNNGLGD----RGLRLLAKGL--------------KDLPPALEKLVLGRNRLEGASCEALAKALRANR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1112 GPLEIQLSCKSLNDDSLKTLLQRLPQIPQLSQLRLTHTVLSSRSPFLLADIFNLCPWVQKVNLRSlshavlhfnsneehe 1191
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747941 1192 avccgfpgCSLKQEHMETLCCALSkckaisqldltdnllddSGLRCLLGylpqlpisgwLDLSHNSISQEGVLYLLETLP 1271
Cdd:cd00116 231 --------NNLTDAGAAALASALL-----------------SPNISLLT----------LSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1958747941 1272 SYPHIQEVSVS 1282
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| |
