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    SHP2 K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818883, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SHP2
    Official Full Name
    K-box region and MADS-box transcription factor family protein
    Primary source
    TAIR:AT2G42830
    Locus tag
    AT2G42830
    See related
    Araport:AT2G42830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 5; AGL5; F7D19.17; F7D19_17; SHATTERPROOF 2
    Summary
    AGAMOUS [AG]-like MADS box protein (AGL5) involved in fruit development (valve margin and dehiscence zone differentiation). A putative direct target of AG. SHP2 has been shown to be a downstream gene of the complex formed by AG and SEP proteins (SEP4 alone does not form a functional complex with AG).
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    Genomic context

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    See SHP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (17820114..17824013)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 5.2 Neighboring gene HVA22-like protein F Neighboring gene ncRNA Neighboring gene protodermal factor 1 Neighboring gene cytochrome P450, family 718

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High SHP2 expression determines the efficacy of PD-1/PD-L1 inhibitors in advanced KRAS mutant non-small cell lung cancer. Feng HB, et al. Thorac Cancer, 2021 Oct. PMID 34490728, Free PMC Article
    2. A new role for the SHATTERPROOF genes during Arabidopsis gynoecium development. Colombo M, et al. Dev Biol, 2010 Jan 15. PMID 19900437
    3. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana. Ehlers K, et al. PLoS One, 2016. PMID 27776173, Free PMC Article
    4. Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1. Vrebalov J, et al. Plant Cell, 2009 Oct. PMID 19880793, Free PMC Article
    5. Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. Krejci P, et al. J Biol Chem, 2007 Feb 2. PMID 17145761

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High SHP2 expression determines the efficacy of PD-1/PD-L1 inhibitors in advanced KRAS mutant non-small cell lung cancer.
      Title: High SHP2 expression determines the efficacy of PD-1/PD-L1 inhibitors in advanced KRAS mutant non-small cell lung cancer.
    2. Gab1/SHP2/p38MAPK signaling pathway and Ang-2 have an essential role in regulating thrombin-induced monocyte adhesion and vascular leakage
      Title: Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability.
    3. Study identified new roles for SHP1 and SHP2: they are required for synchronized ovule maturation and subsequent fertilization/seed maturation, seed mucilage production, and have an inhibitory effect which is antagonistic to the ABS function in controlling formative divisions and cell shape of the inner integument and seed coat layers.
      Title: The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana.
    4. The stk shp1 shp2 ant quadruple mutant ovule lacks integument development as in ant single mutant.
      Title: Genetic interaction between AINTEGUMENTA (ANT) and the ovule identity genes SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHATTERPROOF2 (SHP2).
    5. SHP1/2 and TAGL1, while distinct in molecular function, regulate similar activities via their necessity for seed dispersal in Arabidopsis and tomato, respectively.
      Title: Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1.
    6. The present work identifies a new function for SHP1 and SHP2 genes in promoting stigma, style and medial tissue development.
      Title: A new role for the SHATTERPROOF genes during Arabidopsis gynoecium development.
    7. Bisindolylmaleimide I abolishes the FGF2-mediated association of Shp2 tyrosine phosphatase with Frs2 and Gab1.
      Title: Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129844.5
    NM_180046.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_565986.1
    • SHATTERPROOF 2 (SHP2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT3G58780.1); Has 7190 Blast hits to 7188 proteins in 915 species: Archae - 0; Bacteria - 3; Metazoa - 641; Fungi - 306; Plants - 6161; Viruses - 0; Other Eukaryotes - 79 (source: NCBI BLink).
    NP_850377.1
    • SHATTERPROOF 2 (SHP2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT3G58780.1); Has 7166 Blast hits to 7164 proteins in 913 species: Archae - 0; Bacteria - 3; Metazoa - 641; Fungi - 303; Plants - 6138; Viruses - 0; Other Eukaryotes - 81 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17820114..17824013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129844.5 → NP_565986.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ83, P29385, Q84WG7, Q9SJH3
      UniProtKB/TrEMBL
      A0A654F6K9, Q5XXE7, Q5XXF6, Q5XXG9
      Conserved Domains (2) summary
      cd00265
      Location:17 → 90
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:103 → 186
      K-box; K-box region

    2. NM_180046.2 → NP_850377.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5XXE7, Q5XXF6
      Conserved Domains (2) summary
      cd00265
      Location:17 → 90
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:103 → 188
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29385.1

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