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Conserved domains on  [gi|18406070|ref|NP_565986|]
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K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10083661)

MADS-box domain-containing protein with a K-box coiled-coil region; the MADS-box domain (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor) is a conserved DNA-binding/dimerization region present in a variety of transcription factors from three eukaryotic kingdoms, plants, animals, and fungi

Gene Ontology:  GO:0003700
PubMed:  29802068

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 17-90 1.27e-43

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 141.92  E-value: 1.27e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYANNSVRGTIERYKKACSD 90
Cdd:cd00265   1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGS 74
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 103-186 1.37e-30

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


:

Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 109.09  E-value: 1.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18406070   103 QYYQQEASKLRRQIRDIQNLNRHILGESLGSLNFKELKNLESRLEKGISRVRSKKHEMLVAEIEYMQKREIELQNDNMYL 182
Cdd:pfam01486   7 ENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKEL 86


                  ....
gi 18406070   183 RSKI 186
Cdd:pfam01486  87 RKKL 90
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 17-90 1.27e-43

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 141.92  E-value: 1.27e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYANNSVRGTIERYKKACSD 90
Cdd:cd00265   1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGS 74
MADS smart00432
MADS domain;
17-73 4.07e-33

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 114.58  E-value: 4.07e-33
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18406070     17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYA 73
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 103-186 1.37e-30

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 109.09  E-value: 1.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18406070   103 QYYQQEASKLRRQIRDIQNLNRHILGESLGSLNFKELKNLESRLEKGISRVRSKKHEMLVAEIEYMQKREIELQNDNMYL 182
Cdd:pfam01486   7 ENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKEL 86


                  ....
gi 18406070   183 RSKI 186
Cdd:pfam01486  87 RKKL 90
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
25-72 1.46e-26

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 97.11  E-value: 1.46e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18406070    25 RIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEY 72
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 17-73 1.45e-10

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 60.41  E-value: 1.45e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYA 73
Cdd:COG5068  82 TGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFT 138
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 17-90 1.27e-43

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 141.92  E-value: 1.27e-43
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYANNSVRGTIERYKKACSD 90
Cdd:cd00265   1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGS 74
MADS smart00432
MADS domain;
17-73 4.07e-33

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 114.58  E-value: 4.07e-33
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18406070     17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYA 73
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 17-73 4.67e-33

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 114.15  E-value: 4.67e-33
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYA 73
Cdd:cd00120   1 GRGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFW 57
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 103-186 1.37e-30

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 109.09  E-value: 1.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18406070   103 QYYQQEASKLRRQIRDIQNLNRHILGESLGSLNFKELKNLESRLEKGISRVRSKKHEMLVAEIEYMQKREIELQNDNMYL 182
Cdd:pfam01486   7 ENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKEL 86


                  ....
gi 18406070   183 RSKI 186
Cdd:pfam01486  87 RKKL 90
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 17-86 1.00e-27

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 101.18  E-value: 1.00e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYAN-NSVRGTIERYKK 86
Cdd:cd00266   1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPsSEVEGVISRFEV 71
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
25-72 1.46e-26

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 97.11  E-value: 1.46e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18406070    25 RIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEY 72
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 17-73 1.45e-10

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 60.41  E-value: 1.45e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18406070  17 GRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALVIFSTRGRLYEYA 73
Cdd:COG5068  82 TGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFT 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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