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    Cdkn1b cyclin-dependent kinase inhibitor 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83571, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cdkn1bprovided by RGD
    Official Full Name
    cyclin-dependent kinase inhibitor 1Bprovided by RGD
    Primary source
    RGD:69062
    See related
    EnsemblRapid:ENSRNOG00000007249 AllianceGenome:RGD:69062
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p27; Kip1; CDKN4; Cdki1b; P27KIP1
    Summary
    Enables Hsp70 protein binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 428.5), Spleen (RPKM 220.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdkn1b in Genome Data Viewer
    Location:
    4q43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169491273..169496500)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167760067..167765177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168689043..168694159)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene uncharacterized LOC108350781 Neighboring gene G protein-coupled receptor 19 Neighboring gene apolipoprotein L domain containing 1 Neighboring gene proteasome maturation protein pseudogene Neighboring gene DEAD-box helicase 47

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding PubMed 
    enables cyclin binding  
    enables cyclin-dependent protein kinase activating kinase regulator activity  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity  
    enables molecular adaptor activity  
    enables molecular function inhibitor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase inhibitor activity  
    enables protein phosphatase binding  
    enables protein-containing complex binding PubMed 
    enables protein-containing complex binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding PubMed 
    enables ubiquitin ligase activator activity  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 57
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within Notch signaling pathway  
    acts_upstream_of apoptotic process  
    involved_in autophagic cell death  
    acts_upstream_of_or_within cellular response to antibiotic  
    involved_in cellular response to hypoxia PubMed 
    acts_upstream_of_or_within cellular response to lithium ion  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    acts_upstream_of epithelial cell apoptotic process  
    acts_upstream_of epithelial cell proliferation involved in prostate gland development  
    involved_in heart development  
    acts_upstream_of_or_within inner ear development  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cardiac muscle tissue regeneration  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cyclin-dependent protein kinase activity  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity PubMed 
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process  
    involved_in negative regulation of epithelial cell proliferation  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development  
    involved_in negative regulation of kinase activity  
    involved_in negative regulation of mitotic cell cycle  
    involved_in negative regulation of phosphorylation  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in nuclear export  
    acts_upstream_of_or_within placenta development  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of microtubule polymerization  
    acts_upstream_of_or_within positive regulation of protein catabolic process  
    involved_in positive regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within potassium ion transport  
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle G1/S phase transition  
    acts_upstream_of_or_within regulation of cell migration  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity  
    acts_upstream_of_or_within regulation of exit from mitosis  
    acts_upstream_of_or_within regulation of lens fiber cell differentiation  
    acts_upstream_of_or_within regulation of mitotic cell cycle  
    involved_in response to amino acid PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to glucose PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within sensory perception of sound  
    Items 1 - 25 of 57
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endosome  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 1B
    Names
    Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    cyclin-dependent kinase inhibitor p27
    cyclin-dependent kinase inhibitor p27/Kip1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031762.3NP_113950.2  cyclin-dependent kinase inhibitor 1B

      See identical proteins and their annotated locations for NP_113950.2

      Status: PROVISIONAL

      Source sequence(s)
      AY623040
      UniProtKB/TrEMBL
      F7EXK3, O08769, O35792
      Related
      ENSRNOP00000050173.1, ENSRNOT00000049848.3
      Conserved Domains (1) summary
      pfam02234
      Location:3277
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169491273..169496500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237539.5XP_006237601.1  cyclin-dependent kinase inhibitor 1B isoform X1

      See identical proteins and their annotated locations for XP_006237601.1

      UniProtKB/TrEMBL
      F7EXK3, O08769, O35792
      Conserved Domains (1) summary
      pfam02234
      Location:3277
      CDI; Cyclin-dependent kinase inhibitor
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