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Rnf123 ring finger protein 123 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100190936, updated on 4-Jan-2025

Summary

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Symbol
Rnf123provided by RGD
Full Name
ring finger protein 123provided by RGD
Primary source
RGD:2301394
See related
EnsemblRapid:ENSRNOG00000033378 AllianceGenome:RGD:2301394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein maturation; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 167.6), Muscle (RPKM 112.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf123 in Genome Data Viewer
Location:
8q32
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117618776..117646400, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108740176..108768177, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116829050..116857050, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480233 Neighboring gene cadherin-related family member 4 Neighboring gene inositol hexakisphosphate kinase 1 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene macrophage stimulating 1 Neighboring gene acylaminoacyl-peptide hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation. Yuan Y, et al. J Cell Physiol, 2019 Dec. PMID 31148189, Free PMC Article
  2. KPC1 expression and essential role after acute spinal cord injury in adult rat. Zhao J, et al. Neurochem Res, 2011 Mar. PMID 21229311
  3. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF123
Names
RING-type E3 ubiquitin transferase RNF123
kip1 ubiquitination-promoting complex protein 1
NP_001178509.1
XP_006243753.1
XP_006243755.1
XP_006243757.1
XP_063120775.1
XP_063120776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191580.1 → NP_001178509.1  E3 ubiquitin-protein ligase RNF123

    See identical proteins and their annotated locations for NP_001178509.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    D3ZXK7
    Related
    ENSRNOP00000041545.3, ENSRNOT00000043825.6
    Conserved Domains (2) summary
    pfam13920
    Location:1248 → 1296
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd12882
    Location:121 → 248
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117618776..117646400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243695.5 → XP_006243757.1  E3 ubiquitin-protein ligase RNF123 isoform X1

    See identical proteins and their annotated locations for XP_006243757.1

    UniProtKB/Swiss-Prot
    D3ZXK7
    Conserved Domains (2) summary
    pfam13920
    Location:1248 → 1296
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd12882
    Location:121 → 248
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

  2. XM_006243691.5 → XP_006243753.1  E3 ubiquitin-protein ligase RNF123 isoform X1

    See identical proteins and their annotated locations for XP_006243753.1

    UniProtKB/Swiss-Prot
    D3ZXK7
    Conserved Domains (2) summary
    pfam13920
    Location:1248 → 1296
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd12882
    Location:121 → 248
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

  3. XM_063264705.1 → XP_063120775.1  E3 ubiquitin-protein ligase RNF123 isoform X2

    UniProtKB/Swiss-Prot
    D3ZXK7
    Related
    ENSRNOP00000110165.1, ENSRNOT00000159612.1

  4. XM_006243693.5 → XP_006243755.1  E3 ubiquitin-protein ligase RNF123 isoform X1

    See identical proteins and their annotated locations for XP_006243755.1

    UniProtKB/Swiss-Prot
    D3ZXK7
    Conserved Domains (2) summary
    pfam13920
    Location:1248 → 1296
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cd12882
    Location:121 → 248
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

  5. XM_063264706.1 → XP_063120776.1  E3 ubiquitin-protein ligase RNF123 isoform X3

    UniProtKB/TrEMBL
    F1LMI7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZXK7.1 GenPept UniProtKB/Swiss-Prot:D3ZXK7

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