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    iars1 isoleucyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 334393, updated on 9-Dec-2024

    Summary

    Official Symbol
    iars1provided by ZNC
    Official Full Name
    isoleucyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6325
    See related
    Ensembl:ENSDARG00000007955 AllianceGenome:ZFIN:ZDB-GENE-030131-6325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    iars; fi46h05; zgc:63790; wu:fi46h05
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Acts upstream of or within regulation of sprouting angiogenesis. Is expressed in several structures, including brain; digestive system; optic cup; pectoral fin bud; and swim bladder. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
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    Genomic context

    See iars1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1337620..1392468, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1311032..1365880, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 11b Neighboring gene ATPase plasma membrane Ca2+ transporting 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ribosomal protein L29

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding  
    enables aminoacyl-tRNA editing activity  
    enables aminoacyl-tRNA ligase activity  
    enables isoleucine-tRNA ligase activity  
    enables ligase activity  
    enables nucleotide binding  
    enables tRNA binding  

    General protein information

    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    NP_956190.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199896.2 → NP_956190.2  isoleucine--tRNA ligase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      CABZ01073866, CABZ01073867, CABZ01073868, CABZ01073869, CABZ01073870, CABZ01073871, CABZ01073872, CABZ01073873, CABZ01073874, CABZ01073875, CABZ01073876, EH583791, EH601215
      UniProtKB/TrEMBL
      A0A8N7UZX0
      Related
      ENSDARP00000009149.9, ENSDART00000004423.10
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:39 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:11 → 1070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      1337620..1392468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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