|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
11-1070 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1674.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 11 FPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGL 90
Cdd:PLN02882 10 FPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 91 PVEYEIDKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSG 170
Cdd:PLN02882 90 PVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 171 LVYRGVKVMPFSTACNTPLSNFEANQNYKDVQDPSVIVNFPLLEDP-SVSLIAWTTTPWTLPSNLALCVNPELIYVRVKD 249
Cdd:PLN02882 170 LVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDPdNASFVAWTTTPWTLPSNLALCVNPNFTYVKVRN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 250 NSSQKIYIMMEARLVALF-------------KSDSEYTILERFPGKTLKGKKYKPLFEYFIKCKETgAFSVVMDNYVRDD 316
Cdd:PLN02882 250 KYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADDYVTDD 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 317 DGTGVVHQAPYFGADDYRVCMEYDIIQRDSAPICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHS 396
Cdd:PLN02882 329 SGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHS 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 397 YPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEFVKEKRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFE 476
Cdd:PLN02882 409 YPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGE 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 477 EVVCVGSMAELEELTGIKVTDLHRESIDGLTIPSRCGKGQ--LRRVSEVFDCWFESGSMPYAQVHYPFENRREFEDAFPA 554
Cdd:PLN02882 489 EVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPEFgvLRRVDDVFDCWFESGSMPYAYIHYPFENKELFEKNFPA 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 555 DFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPVVR 634
Cdd:PLN02882 569 DFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLINSPVVR 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 635 AENLRFKEEGVRDVLKDVFLPWYNAYRFLVQNVQRLQKEEGVEFL-YNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGA 713
Cdd:PLN02882 649 AEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVREEMGA 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 714 YRLYTVVPKLVKFVDMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLRHLLDPAav 793
Cdd:PLN02882 729 YRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGS-- 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 794 EEkdtgSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVVVIHQDPEALTDIQ-SLQNYILE 872
Cdd:PLN02882 807 EE----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKLKEYVLE 882
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 873 ELNVRQLTLSTDKDRYgIRLRAEPDHMVLGKRLKGAFKSVTASIKELKSEELEEFQKTGCIVVDGHDLREEDLRLMYTFD 952
Cdd:PLN02882 883 ELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIKVVRDFK 961
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 953 QSSG-SASQYEAHSDAQVLVLLDVTPDQAMLDEGVAREVINRIQKLRKKGHLVPSDEITVFYRCQPAGE--YLHQVIEAH 1029
Cdd:PLN02882 962 RPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLDEVDesALSQVLKSQ 1041
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 940373610 1030 TDFILATTKAPLRAYPVCPNASVIVQENTQLKGSDLELTIV 1070
Cdd:PLN02882 1042 AQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSFKIS 1082
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
3-999 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1158.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 3 EAVPESIHFPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERR 82
Cdd:PTZ00427 66 TGVSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERK 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 83 FGWDCHGLPVEYEIDKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWV 162
Cdd:PTZ00427 146 FGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWV 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 163 FKQLYDSGLVYRGVKVMPFSTACNTPLSNFEANQNYKDVQDPSVIVNFPLLED-PSVS---------------------- 219
Cdd:PTZ00427 226 FSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFVLCSDfPKVEeecnieedkqllgekysvlynn 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 220 -----------------------LIAWTTTPWTLPSNLALCVNPELIYVRVKDNSSQKIYIMMEARL---VALFKSDSE- 272
Cdd:PTZ00427 306 krensnngnnnstnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLewiMKELKWNVEd 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 273 YTILERFPGKTLKGKKYKPLFEYFIK---CKETgAFSVVMDNYVRDDDGTGVVHQAPYFGADDYRVCMEYDIIQRDSAP- 348
Cdd:PTZ00427 386 LKIVNRFKGKELKGLRYKPLFTNFYEkynFKER-AYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKNIf 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 349 ICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLD 428
Cdd:PTZ00427 465 IDPLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVK 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 429 NNSKCYWVPEFVKEKRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCVGSMAELEELTGIK-VTDLHRESIDGLT 507
Cdd:PTZ00427 545 NNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIE 624
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 508 IPSRCGKG--QLRRVSEVFDCWFESGSMPYAQVHYPFENRRE-FEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPF 584
Cdd:PTZ00427 625 IKNPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPF 704
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 585 KNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVFLPWYNAYRFLV 664
Cdd:PTZ00427 705 KNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFS 784
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 665 QNVQRLQKEEGVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFVDMLTNWYVRMNRRRLKG 744
Cdd:PTZ00427 785 QEVTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRG 864
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 745 ESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLRHLLDPA-AVEEKDTG--------------SIHYLMLPQV 809
Cdd:PTZ00427 865 SLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNeHNENNETGntkegdlnrgvihkSVHFIMLPQV 944
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 810 RES-LIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVVVIHQDPEALTDIQSLQNYILEELNVRQLTLSTDKDry 888
Cdd:PTZ00427 945 DEKyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS-- 1022
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 889 GIRLRAEPDHMVLGKRLKGAFKSVTASIKELKSEELEEFQKTGCIVVDGHDLREEDL--RLMYTFDQSSGsasqyEAHSD 966
Cdd:PTZ00427 1023 CLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFQNDNT-----DIISN 1097
|
1050 1060 1070
....*....|....*....|....*....|...
gi 940373610 967 AQVLVLLDVTPDQAMLDEGVAREVINRIQKLRK 999
Cdd:PTZ00427 1098 NYVTILMDFTTDQQLENMASARELCNHIQKMRK 1130
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
11-997 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1038.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 11 FPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGL 90
Cdd:COG0060 18 LPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCHGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 91 PVEYEIDKSLNIKGPEDVmKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSG 170
Cdd:COG0060 98 PIELKVEKELGIKKKDIE-KVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 171 LVYRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVIVNFPLLEDPS------VSLIAWTTTPWTLPSNLALCVNPELIY 244
Cdd:COG0060 177 LLYKGLKPVPWCPRCGTALAEAEVE--YKDVTSPSIYVKFPVKDEKAlllledAYLVIWTTTPWTLPANLAVAVHPDIDY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 245 VRVKDNSSQKiYIMMEARLVALFK--SDSEYTILERFPGKTLKGKKYKPLFEYFIKCKetGAFSVVMDNYVRDDDGTGVV 322
Cdd:COG0060 255 VLVEVTGGER-LILAEALVEAVLKelGIEDYEVLATFKGAELEGLRYEHPFYYVVGYD--RAHPVILGDYVTTEDGTGIV 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 323 HQAPYFGADDYRVCMEYDIiqrdsAPICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWR 402
Cdd:COG0060 332 HTAPGHGEDDFEVGKKYGL-----PVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWR 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 403 SDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEFvKEKRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVV--- 479
Cdd:COG0060 407 CKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGELHrte 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 480 -CVGSMAE-LEELtGIKV---TDLHRESIDGlTIPSRCGKGQLRRVSEVFDCWFESGSMPYAQVhypfENRREFedAFPA 554
Cdd:COG0060 486 eVIGSVAElLEEE-GADAwfeLDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENREEL--HFPA 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 555 DFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPvvR 634
Cdd:COG0060 558 DFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSD--Y 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 635 AENLRFKEEGVRDVlKDVFLPWYNAYRFLVQNVQRLQ-KEEGVEflYNERTSsvsnniMDKWIQSFTQSLIQFFRDEMGA 713
Cdd:COG0060 636 WGDLRFSDEILKEV-RDVYRRLRNTYRFLLANLDDFDpAEDAVP--YEDLPE------LDRWILSRLNELIKEVTEAYDN 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 714 YRLYTVVPKLVKFV-DMLTNWYVRMNRRRL-KGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLRHlldpa 791
Cdd:COG0060 707 YDFHRAYRALHNFCvEDLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPG----- 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 792 aveeKDTGSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGR----VIRDRKTlpIKYPLKEVVVIHQDPEALTDIQSLQ 867
Cdd:COG0060 782 ----EAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEELAAALESLG 855
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 868 NYILEELNVRQLTLSTDKDRYGirlraepdhmvlgkrlKGAFKSvtasikelkseeleefqktgcivvdghdLREEDLRL 947
Cdd:COG0060 856 DLLAEELNVSEVELVDDAEDLG----------------KDALKA----------------------------LDVEGISV 891
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|
gi 940373610 948 MYTFDQSSGSASQYEAHsdaqvlVLLDVTPDQamldEGVAREVINRIQKL 997
Cdd:COG0060 892 TVEVEKADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
4-863 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 990.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 4 AVPESIHFPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRF 83
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 84 GWDCHGLPVEYEIDKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVF 163
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 164 KQLYDSGLVYRGVKVMPFSTACNTPLSNFEANQ--NYKDVQDPSVIVNFPLLEDP-------SVSLIAWTTTPWTLPSNL 234
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 235 ALCVNPELIYVRVKDNSSQKIYIMMEARLVALF-KSDSEYTILERFPGKTLKGKKYKPLFEYFIKCKETGAFSVVMDNYV 313
Cdd:TIGR00392 241 AIAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 314 RDDDGTGVVHQAPYFGADDYRVCMEYDIIQrdsapICPVDPSGIFTPEVTHFAGQYVKDADKNIIK-------WLKENGR 386
Cdd:TIGR00392 321 TTEDGTGIVHTAPGHGEEDYEIGKKYGLEV-----LSPVDEKGVYTEGVNDFQGRFVKDADKDIIKankiiieQLKDKGL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 387 LVSASSFKHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEFVkEKRFGNWLRDARDWAVSRNRYWGTP 466
Cdd:TIGR00392 396 LLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIP 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 467 IPLWVSDDFEEVVCVGSMAELEE---LTGIKV--TDLHRESIDGLTIPSRCGkGQLRRVSEVFDCWFESGSMPYAQVHYP 541
Cdd:TIGR00392 475 IPIWYCEDTGEPIVVGSIEELIElieLKGIDAwfEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYP 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 542 FENrREFEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGAD 621
Cdd:TIGR00392 554 FEN-EKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGAD 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 622 ALRLYLINSpvVRAENLRFKEEGVRDVLKDVFLPWYNAYRFLVQ--NVQRLQKEEGVEFLYnertssvSNNIMDKWIQSF 699
Cdd:TIGR00392 633 ILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVAVE-------KFPEEDRWILSR 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 700 TQSLIQFFRDEMGAYRLYTVVPKLVKFVDM-LTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITE 778
Cdd:TIGR00392 704 LNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAE 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 779 LMYQNLrhlldpaaVEEKDTGSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVVVIHQDPE 858
Cdd:TIGR00392 784 EIYQNL--------PGGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEA 855
|
....*
gi 940373610 859 ALTDI 863
Cdd:TIGR00392 856 VLKAV 860
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-639 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 895.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 17 QILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEYEI 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 97 DKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGV 176
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 177 KVMPFSTACNTPLSNFEAnqNYKDVQDPSVIVNFPLLEDPSVSLIAWTTTPWTLPSNLALCVNPELIYVrvkdnSSQKIY 256
Cdd:pfam00133 161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYV-----ITGEGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 257 IMMEARLVALFKSDSEYTILERFPGKTLKGKKYKPLFeyfikckETGAFSVVMDNYVRDDDGTGVVHQAPYFGADDYRVC 336
Cdd:pfam00133 234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 337 MEYDIiqrdsAPICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSDTPLIYKAVPSWF 416
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 417 IRVEHMVEKLLDNNSKCYWVPEFvKEKRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCVGSMAELEELT---GI 493
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRfeeEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 494 KVTDLHRESIDGLtipsRCGKGQLRRVSEVFDCWFESGSMPYAQVHYPFENRREFEDAFPADFIAEGIDQTRGWFYTLLV 573
Cdd:pfam00133 461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 940373610 574 LSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-640 |
2.25e-165 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 495.60 E-value: 2.25e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 39 PRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEYEIDKSLNIKGPEDVMKMGIEEYNK 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 119 QCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPfstacntplsnfeanqny 198
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVP------------------ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 199 kdvqdpsvivnFPLLedpsvsliawtttpwtlpsnlalcvnpeliyvrvkdnssqkiyimmearlvalfksdseytiler 278
Cdd:cd00818 143 -----------WPLI----------------------------------------------------------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 279 fpgktlkgkkYKPLFEYFIKcketgafsvvmdnyvrdddgtgvvhqapyfgaddyrvcmeydiiqrdsapicpvdpsgif 358
Cdd:cd00818 147 ----------YRATPQWFIR------------------------------------------------------------ 156
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 359 tpeVTHFAGQYVKDADKniIKWlkengrlvsassfkhsypfcwrsdtpliykaVPSWfirvehmveklldnnskcywvpe 438
Cdd:cd00818 157 ---VTKIKDRLLEANDK--VNW-------------------------------IPEW----------------------- 177
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 439 fVKEkRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCvgsmaeleeltgikvtdlhresidgltipsrcgkgqlR 518
Cdd:cd00818 178 -VKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-------------------------------------R 218
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 519 RVSEVFDCWFESGSMPYAQVHYPFENrREFEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDG 598
Cdd:cd00818 219 RVPDVLDVWFDSGSMPYAQLHYPFEN-EDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDG 297
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 940373610 599 QKMSKRKKNYPDPGLIVQSYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818 298 RKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
15-892 |
6.93e-121 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 396.35 E-value: 6.93e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 15 EEQILQFWQKNDCFQecLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEY 94
Cdd:TIGR00422 11 EKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 95 EIDKSLNIKGPE--DVmkmGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLV 172
Cdd:TIGR00422 89 KVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 173 YRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVIVNFPLLEDPSVSLIAWTTTPWTLPSNLALCVNPEliyvrvkdnss 252
Cdd:TIGR00422 166 YRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE----------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 253 qkiyimmearlvalfksDseytilERFpgKTLKGKKYK-PLFEYFIKcketgafsVVMDNYVRDDDGTGVVHQAPYFGAD 331
Cdd:TIGR00422 233 -----------------D------ERY--KHLIGKKVIlPLTGRKIP--------IIADEYVDMEFGTGAVKVTPAHDFN 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 332 DYRVCMEY-----DIIQRDsapicpvdpsGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSDTP 406
Cdd:TIGR00422 280 DYEWGKRHnlefiNILDED----------GLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTV 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 407 LIYKAVPSWFIRVEHMVEKLLD--NNSKCYWVPEFVkEKRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCVGSM 484
Cdd:TIGR00422 350 VEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEE 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 485 AELEEltgikvtdlhresidgltiPSRCG-KGQLRRVSEVFDCWFESGSMPYAQVHYPfENRREFEDAFPADFIAEGIDQ 563
Cdd:TIGR00422 429 PLPDD-------------------KTNTGpSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDI 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 564 TRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSpVVRAENLRFKE- 642
Cdd:TIGR00422 489 IFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDINFDWk 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 643 --EGVRDVLKDVFlpwyNAYRFLVQNV-QRLQKEEGVEFLynertssvsnNIMDKWIQSFTQSLIQFFRDEMGAYRLYTV 719
Cdd:TIGR00422 568 rvESARNFLNKLW----NASRFVLMNLsDDLELSGGEEKL----------SLADRWILSKLNRTIKEVRKALDKYRFAEA 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 720 VPKLVKFV-DMLTNWYVRMNRRRLKGESGSEDCVrALETLFSVLFSMCRLMAPFTPFITELMYQNLRHLLDpaaveekdt 798
Cdd:TIGR00422 634 AKALYEFIwNDFCDWYIELVKYRLYNGNEAEKKA-ARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGAD--------- 703
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 799 gSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKeVVVIHQDPEALTDIQSLQNYILEELNVRQ 878
Cdd:TIGR00422 704 -SIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAINFSE 781
|
890
....*....|....
gi 940373610 879 LTLSTDKDRYGIRL 892
Cdd:TIGR00422 782 VEVVIEKPEVTEAV 795
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
12-794 |
1.70e-108 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 365.25 E-value: 1.70e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 12 PTEEEQILQFWQKNDCFQECLKQSKSRPrFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLP 91
Cdd:PLN02843 6 VTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 92 VEYEIDKSLNikgPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGL 171
Cdd:PLN02843 85 IELKVLQSLD---QEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 172 VYRGVKVMPFSTACNTPLSnfEANQNYKDVQ-DPSVIVNFPLLED------------PSVSLIAWTTTPWTLPSNLALCV 238
Cdd:PLN02843 162 IYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVVSPsetspeeleeflPGLSLAIWTTTPWTMPANAAVAV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 239 NPELIY--VRVKDNS--------------------SQKIYIMMEARLVALF--KSDSEYTILERFPGKTLKGKKYK-PLF 293
Cdd:PLN02843 240 NDKLQYsvVEVQSFSedestsggnkkkrpgnvlkeQQKLFLIVATDLVPALeaKWGVKLVVLKTFPGSDLEGCRYIhPLY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 294 EYfiKCKetgafSVVMDNYVRDDDGTGVVHQAPYFGADDYRVCMEYDIiqrdsaPI-CPVDPSGIFTPEVTHFAGQYV-K 371
Cdd:PLN02843 320 NR--ESP-----VVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGL------PLlSPVDDAGKFTEEAGQFSGLSVlG 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 372 DADKNIIKWLKENGRLVSASSFKHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEfVKEKRFGNWLRD 451
Cdd:PLN02843 387 EGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMVSG 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 452 ARDWAVSRNRYWGTPIPLWVSDDFEEVVcvgsMAE--LEELTGI---KVTDLHRE-SIDGLTIPSRCGKG-QLRRVSEVF 524
Cdd:PLN02843 466 RSDWCISRQRTWGVPIPVFYHVETKEPL----MNEetIAHVKSIvaqKGSDAWWYmDVEDLLPEKYRDKAsDYEKGTDTM 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 525 DCWFESGSmPYAQVhypFENRREFedAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKR 604
Cdd:PLN02843 542 DVWFDSGS-SWAGV---LGSREGL--SYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKS 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 605 KKNYPDPGLIVQ---------SYGADALRLY----------LINSPVVRAenlrfkeegvrdvLKDVFLPWYNAYRFLVQ 665
Cdd:PLN02843 616 LGNVVDPRLVIEggknqkqepAYGADVLRLWvasvdytgdvLIGPQILKQ-------------MSDIYRKLRGTLRYLLG 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 666 NVQRLQKEEGVEflYNERTSsvsnniMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFVDM-LTNWYVRMNRRRLKG 744
Cdd:PLN02843 683 NLHDWKPDNAVP--YEDLPS------IDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNFYLDVAKDRLYV 754
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|.
gi 940373610 745 ESGSEDCVRALET-LFSVLFSMCRLMAPFTPFITELMYQNLRHLLDPAAVE 794
Cdd:PLN02843 755 GGTTSFTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAE 805
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-886 |
7.30e-103 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 345.25 E-value: 7.30e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 1 MVEAVPESIHFPTEEEQILQFWQKNDCFQEclKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVE 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 81 RRFGWDCHGLPVEYEIDKSLNIKgPEDVmkmGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVW 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGIR-KDDI---SREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 161 WVFKQLYDSGLVYRGVKVMPFSTACNTPLSnfEANQNYKDVQDPSVIVNFPLLEDPSVsLIAwTTTPWTLPSNLALCVNP 240
Cdd:PRK13208 156 KSFLDLYKKGLIYRAEAPVLWCPRCETAIA--QAEVEYREREGKLNYIKFPVEDGEEI-EIA-TTRPELLPACVAVVVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 241 EliyvrvkdnssqkiyimmearlvalfksDSEYtilerfpgKTLKGKKYK-PLFEYFIKcketgafsVVMDNYVRDDDGT 319
Cdd:PRK13208 232 D----------------------------DERY--------KHLVGKTAIvPLFGVEVP--------ILADPLVDPDFGT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 320 GVVhqapY---FGaD--DYRVCMEYD-----IIQRDsapicpvdpsGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVS 389
Cdd:PRK13208 268 GAV----MictFG-DktDVTWWRELNlptriIIDED----------GRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGK 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 390 ASSFKHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEFVKeKRFGNWLRD-ARDWAVSRNRYWGTPIP 468
Cdd:PRK13208 333 QEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPIP 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 469 LWVSDDFEEVVcvgsMAELEELTgikvtdlHRESIDGLTIPS--RCGKGQLRRVSEVFDCWFESGSMPYAQVHYPfENRR 546
Cdd:PRK13208 412 VWYCKDCGHPI----LPDEEDLP-------VDPTKDEPPGYKcpQCGSPGFEGETDVMDTWATSSITPLIVTGWE-RDED 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 547 EFEDAFPADFIAEGIDQTRGW-FYTLLvLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRL 625
Cdd:PRK13208 480 LFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRY 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 626 YLINSPVvrAENLRFKEEGV----RDVLKdvflpWYNAYRFlVQNVQRLQKEEGVEFLynertssvsnNIMDKWIQSFTQ 701
Cdd:PRK13208 559 WAASARL--GSDTPFDEKQVkigrRLLTK-----LWNASRF-VLHFSADPEPDKAEVL----------EPLDRWILAKLA 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 702 SLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELM 780
Cdd:PRK13208 621 KVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEV 700
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 781 YQNLRhlldpaaveekdTGSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVVVIhqDPEAL 860
Cdd:PRK13208 701 WSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVY--GPADL 766
|
890 900
....*....|....*....|....*.
gi 940373610 861 TDIQSLQNYILEELNVRQLTLSTDKD 886
Cdd:PRK13208 767 ELLEAAEEDLKAAGNIEELELVEGDP 792
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
640-833 |
4.51e-89 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 285.60 E-value: 4.51e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 640 FKEEGVRDVLKDVFLPWYNAYRFLVQNVQRLQKEEGVEFLYNErtssvSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTV 719
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVA-----SLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 720 VPKLVKFVDMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLRHLLDpaaveeKDTG 799
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELG------DAPE 149
|
170 180 190
....*....|....*....|....*....|....
gi 940373610 800 SIHYLMLPQVRESLIDQRIESAVSRMQSVIELGR 833
Cdd:cd07961 150 SVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
12-859 |
3.38e-69 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 253.38 E-value: 3.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 12 PTE-EEQILQFWQKNDCFQeCLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGL 90
Cdd:PRK14900 21 HREvEARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 91 PVEYEIDKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSG 170
Cdd:PRK14900 100 ATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 171 LVYRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVI-VNFPLlEDPSVSLIAWTTTPWTLPSNLALCVNPEliyvrvkd 249
Cdd:PRK14900 180 LIYREKKLINWCPDCRTALSDLEVE--HEEAHQGELWsFAYPL-ADGSGEIVVATTRPETMLGDTAVAVHPL-------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 250 nssqkiyimmEARLVALFKSDSEYTILERfpgktlkgkkykplfeyfikcketgAFSVVMDNYVRDDD-GTGVVHQAPYF 328
Cdd:PRK14900 249 ----------DPRYMALHGKKVRHPITGR-------------------------TFPIVADAILVDPKfGTGAVKVTPAH 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 329 GADDYRVCMEYDIIQrdsapICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSDTPLI 408
Cdd:PRK14900 294 DFNDFEVGKRHGLEM-----ITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILE 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 409 YKAVPSWFIRVEHMVEKLLD--NNSKCYWVPEFVKEKRFGnWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCvgsmae 486
Cdd:PRK14900 369 PLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA------ 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 487 leeltgikvtdlhRESIDGLtipSRCGKGQLRRVSEVFDCWFESGSMPYAQVHYPfENRREFEDAFPADFIAEGIDQTRG 566
Cdd:PRK14900 442 -------------RETPEAC---STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIFF 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 567 WFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLInSPVVRAENLRFKE---E 643
Cdd:PRK14900 505 WVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKLAKeriE 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 644 GVRDVLKDVflpwYNAYRFLVQNVQRLQkEEGVEFLYNERTSSvsnnimDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKL 723
Cdd:PRK14900 584 GYRAFANKL----WNASRFALMNLSGYQ-ERGEDPARLARTPA------DRWILARLQRAVNETVEALEAFRFNDAANAV 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 724 VKFV-DMLTNWYVRMNRRRLKGE-SGSEDCVRAleTLFSVLFSMCRLMAPFTPFITELMYQNLRHLLDPAAVEEkdtgSI 801
Cdd:PRK14900 653 YAFVwHELCDWYIELAKEALASEdPEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAD----SV 726
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 940373610 802 HYLMLPQVREslIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPL---KEVVVIHQDPEA 859
Cdd:PRK14900 727 LAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPAL 785
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
15-886 |
1.74e-66 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 242.70 E-value: 1.74e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 15 EEQILQFWQKNDCFQeclKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGF---------H------- 78
Cdd:PRK05729 15 EAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYntlwlpgtdHagiatqm 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 79 -VERRfgwdchglpveyeidksLNIKGP--EDvmkMGIEEYNKQCrsivmryadeWE----------NSVRRMGRWIDFR 145
Cdd:PRK05729 92 vVERQ-----------------LAAEGKsrHD---LGREKFLEKV----------WEwkeesggtitNQLRRLGASCDWS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 146 NDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVIVNFPLlEDPSVSLIAWTT 225
Cdd:PRK05729 142 RERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--YKEVKGKLWHIRYPL-ADGSDYLVVATT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 226 TPWTLPSNLALCVNPEliyvrvkdnssqkiyimmearlvalfksDseytilERFpgKTLKGKKYK-PLFEYFIKcketga 304
Cdd:PRK05729 219 RPETMLGDTAVAVNPE----------------------------D------ERY--KHLIGKTVIlPLVGREIP------ 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 305 fsVVMDNYVRDDDGTGVV-----HqapyfgaD--DYrvcmeyDIIQRDSAPICPV-DPSGIFTPEVTHFAGQYVKDADKN 376
Cdd:PRK05729 257 --IIADEYVDPEFGTGAVkitpaH-------DpnDF------EVGKRHNLPMINImDEDGTINENPGEYQGLDRFEARKA 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 377 IIKWLKENGRLVSASSFKHSYPFCWRSDT---PLIYKavpSWFIRVEHMVEKLLD--NNSKCYWVPE-FvkEKRFGNWLR 450
Cdd:PRK05729 322 IVADLEELGLLVKIEPHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALEavENGEIKFVPErW--EKTYFHWME 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 451 DARDWAVSRNRYWGTPIPLWVSDDFEEVVcvgsmaeleeltgikvtdlhresidGLTIPSRCGKGQLRRVSEVFDCWFES 530
Cdd:PRK05729 397 NIQDWCISRQLWWGHRIPAWYDEDGEVYV-------------------------GREEPEAREKALLTQDEDVLDTWFSS 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 531 GSMPYAQVHYPfENRREFEDAFPADfiaegidqtrgwfytllVLSTA---LF--------------GKPPFKNVIVNGLV 593
Cdd:PRK05729 452 ALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGQVPFKDVYIHGLV 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 594 LASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLI--NSPvvrAENLRFKE---EGVRDvlkdvF---LpwYNAYRFLVQ 665
Cdd:PRK05729 514 RDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRN-----FankL--WNASRFVLM 583
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 666 NVQrlqkEEGVEFLYNERTSSVSnnimDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYVRMNRRRLKG 744
Cdd:PRK05729 584 NLE----GADVGELPDPEELSLA----DRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLELAKPVLQE 655
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 745 ESGSEdcvrALETLFSVLFSMCRLMAPFTPFITELMYQNLrhlldpaaveeKDTGSIHYLML---PQVRESLIDQrIESA 821
Cdd:PRK05729 656 AAKRA----TRATLAYVLEQILRLLHPFMPFITEELWQKL-----------APLGIEESIMLapwPEADEAIDEA-AEAE 719
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940373610 822 VSRMQSVIELGRVIRDRKTLPIKYPLKeVVVIHQDPEALTDIQSLQNYILEELNVRQLTLSTDKD 886
Cdd:PRK05729 720 FEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDE 783
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-885 |
7.44e-64 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 234.95 E-value: 7.44e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 12 PTE-EEQILQFWQKNDCFQEclKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGF---------H--- 78
Cdd:COG0525 9 PKEvEAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYntlwqpgtdHagi 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 79 -----VERRfgwdchglpveyeidksLNIKGP--EDvmkMGIEEYNKQCrsivmryadeWE----------NSVRRMGRW 141
Cdd:COG0525 87 atqavVERQ-----------------LAEEGKsrHD---LGREKFLERV----------WEwkeesggtitNQLRRLGAS 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 142 IDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVIVNFPLlEDPSVSLI 221
Cdd:COG0525 137 CDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKGHLWHIRYPL-ADGSGYIV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 222 AWTTTPWTLPSNLALCVNPEliyvrvkdnssqkiyimmearlvalfksDseytilERFpgKTLKGKKYK-PLFEYFIKck 300
Cdd:COG0525 214 VATTRPETMLGDTAVAVHPE----------------------------D------ERY--KHLIGKTVIlPLVGREIP-- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 301 etgafsVVMDNYVRDDDGTGVV-----HqapyfgaD--DYRVCMEYDIiqrdsAPICPVDPSGIFTPEVTHFAGQYVKDA 373
Cdd:COG0525 256 ------IIADEYVDPEFGTGAVkitpaH-------DpnDFEVGKRHNL-----PMINILDEDGTINENAGKYRGLDRFEA 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 374 DKNIIKWLKENGRLVSASSFKHSYPFCWRSDT---PLIykavpS--WFIRVEHMVEKLLD--NNSKCYWVPE-FvkEKRF 445
Cdd:COG0525 318 RKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEavEDGEIKFVPErW--EKTY 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 446 GNWLRDARDWAVSRNRYWGTPIPLWVSDDfEEVVCVGSMAEleeltgikvtdlhresidgltIPSRCGKGQLRRVSEVFD 525
Cdd:COG0525 391 FHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEPE---------------------ACAKAGSVNLTQDEDVLD 448
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 526 CWFESGSMPYAQVHYPFENRrEFEDAFPADfiaegidqtrgwfytllVLSTA---LF--------------GKPPFKNVI 588
Cdd:COG0525 449 TWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGEVPFKDVY 510
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 589 VNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLI--NSPvvrAENLRFKE---EGVRDvlkdvF---LpWyNAY 660
Cdd:COG0525 511 IHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRN-----FankL-W-NAS 580
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 661 RFLVQNvqrlqkeeGVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYVRMNR 739
Cdd:COG0525 581 RFVLMN--------LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYLELAK 652
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 740 RRLKGESGSEDCVrALETLFSVLFSMCRLMAPFTPFITELMYQNLRhlldpaavEEKDTGSIhylML---PQVRESLIDQ 816
Cdd:COG0525 653 PRLYGGDEAAKRE-TRATLVYVLEQILRLLHPFMPFITEEIWQKLP--------PRKEGESI---MLapwPEADEELIDE 720
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 940373610 817 RIESAVSRMQSVIELGRVIRDRKTLPIKYPLKeVVVIHQDPEALTDIQSLQNYILEELNVRQLTLSTDK 885
Cdd:COG0525 721 EAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
12-889 |
1.16e-52 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 201.77 E-value: 1.16e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 12 PTE-EEQILQFWQKNDCFQ--ECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCH 88
Cdd:PTZ00419 30 PKEvESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 89 GLP----VEYEIDKSLNIK----GPEDVMKMgIEEYNKQcrsivmrYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVW 160
Cdd:PTZ00419 110 GIAtqvvVEKKLMKEENKTrhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 161 WVFKQLYDSGLVYRGVKVMPFSTACNTPLSNFEANqnYKDVQDPSVI----------------VNFPLLEDPSVSLIAWT 224
Cdd:PTZ00419 182 EAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVE--FEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVAT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 225 TTPWTLPSNLALCVNPeliyvrvKDnssqkiyimmearlvalfksdseytilERFpgKTLKGKKYK-PlfeyFIKCKEtg 303
Cdd:PTZ00419 260 TRIETMLGDVAVAVHP-------KD---------------------------ERY--KKLHGKELIhP----FIPDRK-- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 304 aFSVVMD-NYVRDDDGTGVVHQAPYFGADDYrvcmeyDIIQRDSAPICPV-DPSGIFTPEVTHFAGQYVKDADKNIIKWL 381
Cdd:PTZ00419 298 -IPIIADdELVDMEFGTGAVKITPAHDPNDY------EIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEEEL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 382 KENGRLVSASSFKHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDN--NSKCYWVPEFvKEKRFGNWLRDARDWAVSR 459
Cdd:PTZ00419 371 KEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSS-HENVWYHWLENIQDWCISR 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 460 NRYWGTPIP-----------------LWV-SDDFEEvvcvgSMAELEELTGIKVTDLHresidgltipsrcgkgqLRRVS 521
Cdd:PTZ00419 450 QLWWGHRIPayrviskgpetdpsdeePWVvARSEEE-----ALEKAKKKFGLSEEDFE-----------------LEQDE 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 522 EVFDCWFESGSMPYAQVHYPfENRREFEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKM 601
Cdd:PTZ00419 508 DVLDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKM 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 602 SKRKKNYPDPGLIVQSYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV--- 652
Cdd:PTZ00419 587 SKSKGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrv 666
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 653 -----FLP--WyNAYRFLVQNVQRLQKEegVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVK 725
Cdd:PTZ00419 667 vgyrhFCNklW-NAVKFALMKLLKDFNL--PNSTLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYN 743
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 726 F-VDMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLrhlldPAavEEKDTGSIHYL 804
Cdd:PTZ00419 744 FwLYELCDVYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----PN--YLRKSESISIA 816
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 805 MLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVVVIHqDPEALTDIQSLQNYI-----LEELNVRQL 879
Cdd:PTZ00419 817 KYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAK-DAELIELIESAENLIstlakIGSVSVIPP 895
|
970
....*....|
gi 940373610 880 TLSTDKDRYG 889
Cdd:PTZ00419 896 IEEEAEVPKG 905
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-628 |
4.93e-52 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 185.70 E-value: 4.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 40 RFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEYEIDKSLNIKGPEDVmkmgIEEYNKQ 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 120 CRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVmpfstacntplsnfeanqnyk 199
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP--------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 200 dvqdpsvivnfplledpsvsliawtttpwtlpsnlalcvnpeliyVRVKDNssqkiyimmearlvalfksdseytilerf 279
Cdd:cd00668 136 ---------------------------------------------VRITEQ----------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 280 pgktlkgkkykplfeYFIKCKEtgafsvvmdnyVRDDdgtgvvhqapyfgaddyrvcmeydiiqrdsapicpvdpsgift 359
Cdd:cd00668 142 ---------------WFFDMPK-----------FKEK------------------------------------------- 152
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 360 pevthfagqyvkdadknIIKWLKENgrlvsassfkhsypfcwrsdtpliyKAVPSWF-IRVEHMVEKLLDnnskcyWVpe 438
Cdd:cd00668 153 -----------------LLKALRRG-------------------------KIVPEHVkNRMEAWLESLLD------WA-- 182
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 439 fvkekrfgnwlrdardwaVSRNRYWGTPIPLWvsddfeevvcvgsmaeleeltgikvtdlhresidgltipsrcgkgqlr 518
Cdd:cd00668 183 ------------------ISRQRYWGTPLPED------------------------------------------------ 196
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 519 rvseVFDCWFESGSMPYAQVHYPFENrREFEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDG 598
Cdd:cd00668 197 ----VFDVWFDSGIGPLGSLGYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGG 271
|
570 580 590
....*....|....*....|....*....|
gi 940373610 599 QKMSKRKKNYPDPGLIVQSYGADALRLYLI 628
Cdd:cd00668 272 QKMSKSKGNVIDPSDVVEKYGADALRYYLT 301
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-786 |
1.05e-51 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 198.24 E-value: 1.05e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 13 TEEEQILQFWQKNDCFQECLKQSkSRPrFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPV 92
Cdd:PLN02943 64 TSEERIYNWWESQGYFKPNFDRG-GDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 93 EYEIDKSLNIKGPEDVmKMGIEEYNKQCRSIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLV 172
Cdd:PLN02943 142 QLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 173 YRGVKVMPFSTACNTPLSNFEANQNykdvQDPSVI--VNFPLLEDPSVSLIAWTTTPWTLPSNLALCVNPEliyvrvkdn 250
Cdd:PLN02943 221 YQGSYMVNWSPNLQTAVSDLEVEYS----EEPGTLyyIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE--------- 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 251 ssqkiyimmearlvalfksDSEYTileRFPGKT----LKGKKYKPlfeyfikcketgafsVVMDNYVRDDDGTGVVHQAP 326
Cdd:PLN02943 288 -------------------DDRYS---KYIGKMaivpMTYGRHVP---------------IIADRYVDKDFGTGVLKISP 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 327 YFGADDYRvcmeydIIQRDSAPICPVDPSGIFTPEVthfAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSDT- 405
Cdd:PLN02943 331 GHDHNDYL------LARKLGLPILNVMNKDGTLNEV---AGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEv 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 406 --PLIYKavpSWFIRVEHMVEKLLD--NNSKCYWVPEFVkEKRFGNWLRDARDWAVSRNRYWGTPIPLW--VSDDFEEVV 479
Cdd:PLN02943 402 iePLVSK---QWFVTMEPLAEKALKavENGELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEEDY 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 480 CVGSMAElEELTgiKVTDLHRESIdgltipsrcgkgQLRRVSEVFDCWFESGSMPYAQVHYPFENRREFEDAFPADFIAE 559
Cdd:PLN02943 478 IVARSAE-EALE--KAREKYGKDV------------EIYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLET 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 560 GIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPVVRAENLR 639
Cdd:PLN02943 543 GHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLS 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 640 FKEEGVRDVLKDVFlpwYNAYRFLVQNV--------------QRLQKEEGVEFLYNERTSSVSNniMDKWIQSFTQSLIQ 705
Cdd:PLN02943 623 TERLTSNKAFTNKL---WNAGKFVLQNLpsqsdtsawehilaCKFDKEESLLSLPLPECWVVSK--LHELIDSVTTSYDK 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 706 FFRDEMGAyRLYTVvpklvkFVDMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPFITELMYQNLR 785
Cdd:PLN02943 698 YFFGDVGR-EIYDF------FWSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALP 770
|
.
gi 940373610 786 H 786
Cdd:PLN02943 771 Y 771
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
47-630 |
7.97e-50 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 181.68 E-value: 7.97e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 47 PPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEYEIDKSLNIKGPEDvMKMGIEEYNKQCRSIVMR 126
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 127 YADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLvyrgvkvmpfstacntplsnfeanqnykdvqdpsv 206
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGL----------------------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 207 ivnfplledpsvsliawtttpwtlpsnlalcvnpeliyvrvkdnssqkiyimmearlvalfksdseytilerfpgktlkg 286
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 287 kkykplfeyfikcketgafsvvmdnyvrdddgtgvvhqapyfgaddyrvcmeydiIQRDSAPI--CPVDPSGIFTPEVth 364
Cdd:cd00817 133 -------------------------------------------------------IYRDNRLVnwCPKLRTAISDIEV-- 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 365 fagqyvkdadkniikwlkengrlvsassfkhsypfCWRSDTPLIYKAVPSWFIRVEHMVEKLLD--NNSKCYWVPEFVkE 442
Cdd:cd00817 156 -----------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-E 199
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 443 KRFGNWLRDARDWAVSRNRYWGTPIPLWVSDDFEEVVCVGSMAELEELTGIKVTDlhresidgltipsRCGKGQLRRVSE 522
Cdd:cd00817 200 KRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACV-------------PCGGEELKQDED 266
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 523 VFDCWFESGSMPYAQVHYPfENRREFEDAFPADFIAEGIDQTRGW-FYTLLvLSTALFGKPPFKNVIVNGLVLASDGQKM 601
Cdd:cd00817 267 VLDTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKM 344
|
570 580
....*....|....*....|....*....
gi 940373610 602 SKRKKNYPDPGLIVQSYGADALRLYLINS 630
Cdd:cd00817 345 SKSLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-830 |
2.72e-43 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 171.20 E-value: 2.72e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 54 PHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPV-----------EYEIDKSLNIKG-PEDVM-KMGIEEYnkqc 120
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdPETIELYKSLYGiPEEELeKFKDPEY---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 121 rsIVMRYADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPFSTACNTPLsnfeANQNYKD 200
Cdd:PRK12300 77 --IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV----GDHDLLD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 201 VQDPSvIVNFPLL---EDPSVSLIAWTTTPWTLPSNLALCVNPELIYVRVKDNSsqKIYIMMEARLVALFKSDSEYTILE 277
Cdd:PRK12300 151 GEEPE-IVEYTLIkfeESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDG--EKWIVSKEAAEKLSFQDRDVEIIE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 278 RFPGKTLKGKKYK-PLfeyfikckeTGAFSVVMD-NYVRDDDGTGVV-----HqAPYfgadDYRVCMEYDIIQRDSAPIC 350
Cdd:PRK12300 228 EIKGSELIGKKVKnPV---------TGKEVPILPaDFVDPDNGTGVVmsvpaH-APY----DYVALRDLKKNKELLDVIE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 351 PV--------------------------DPS---------------GIFTPEVTHFAGQYVKDADKNIIKWLKENGrlvs 389
Cdd:PRK12300 294 PIplievegygefpakevveklgiksqeDPEleeatkevyraefhkGVLKENTGEYAGKPVREAREKITKDLIEKG---- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 390 aSSFKHsYPF------CwRSDTPLIYKAVP-SWFIRV-----EHMVEKLLDNNSkcyWVPEFVKeKRFGN---WLRDard 454
Cdd:PRK12300 370 -IADIM-YEFsnrpvyC-RCGTECVVKVVKdQWFIDYsdpewKELAHKALDNME---IIPEEYR-KEFENtidWLKD--- 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 455 WAVSRNRYWGTPIPL---WV----SDdfeevvcvgS---MA------ELEELtGIKVTDLHRESIDGLTIpsrcGKGQLR 518
Cdd:PRK12300 440 RACARRRGLGTRLPWdeeWIieslSD---------StiyMAyytiahKIREY-GIKPEQLTPEFFDYVFL----GKGDPE 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 519 RVSEvfdcwfESGsMPYAQVHypfENRREFEDAFPADFIAEGIDqtrgwfytlLV---LS------TALFGK---PpfKN 586
Cdd:PRK12300 506 EVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAIFPEekwP--RG 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 587 VIVNGLVLaSDGQKMSKRKKN-YPdpgL--IVQSYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVLKDvflpWY 657
Cdd:PRK12300 565 IVVNGFVL-LEGKKMSKSKGNvIP---LrkAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQLER----FY 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 658 NayrfLVQNVQRLQKEEGVEFLynertssvsnnimDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLvkFVDMLT--NWYV 735
Cdd:PRK12300 633 E----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYELLNdlRWYL 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 736 RMnrrrlkgesGSEDCVRALETLFSVLFsmcRLMAPFTPFITELMYQNLRHlldpaaveekdTGSIHYLMLPQVRESLID 815
Cdd:PRK12300 694 RR---------VGEANNKVLREVLEIWI---RLLAPFTPHLAEELWHKLGG-----------EGFVSLEKWPEPDESKID 750
|
890
....*....|....*
gi 940373610 816 QRIESAVSRMQSVIE 830
Cdd:PRK12300 751 EEAELAEEYVKRLIE 765
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
15-863 |
1.06e-38 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 156.45 E-value: 1.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 15 EEQILQFWQKNDCFQecLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVE- 93
Cdd:TIGR00396 7 EEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAEn 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 94 YEIDKSLNikgPEDVMKMGIEEYNKQCRSivmryadewensvrrMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVY 173
Cdd:TIGR00396 85 AAIKRGIH---PAKWTYENIANMKKQLQA---------------LGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAY 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 174 RgvKVMPF--------------------STACNTPLSNFEANQ------------------------NYKDVQ------D 203
Cdd:TIGR00396 147 V--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPVEKKELKQwflkitayaeellndleeldhwpeSVKEMQrnwigkS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 204 PSVIVNFPLlEDPSVSLIAWTTTPWTL--PSNLALCVNPELIYVRVKDNSSQKIYIMMEARlvalfKSDSEYTILERFP- 280
Cdd:TIGR00396 225 EGVEITFKI-ADHDEKITVFTTRPDTIfgVTYLALAPEHPLVEKAAENNPKVAAFIKKILN-----KTVAERTKATKEKk 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 281 GKTLKGKKYKPLfeyfikckeTG-AFSVVMDNYVRDDDGTGVVHQAPyfgADDYRvcmEYDIIQRDSAPICPVdpsgift 359
Cdd:TIGR00396 299 GVDTGIKAIHPL---------TGeKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKPV------- 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 360 pevthfagqyVKDADKNIIKWLKENGRLVSASSFKHSypfcwRSDTPLIYKAVPSWFIrvehmvekllDNNskcywvpef 439
Cdd:TIGR00396 357 ----------IDPAEKDLSLTAAYTEDGVLVNSGEFN-----GLNSSEARNAIIDMLE----------KEG--------- 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 440 vKEKRFGNWlrDARDWAVSRNRYWGTPIPLWVSDDfeevvcVGSMAELEELTGIKVTDLhrESIDG-------------- 505
Cdd:TIGR00396 403 -KGKRKVNY--RLRDWGFSRQRYWGEPIPIIHCED------GGVVPVPEEDLPVILPED--VVYDGdggsplsripewvn 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 506 LTIPSrCGKgQLRRVSEVFDCWFESG--SMPYAQVHYP--FENRREFEDAFPADFIAEGIDQT-------RGW---FYTL 571
Cdd:TIGR00396 472 VTCPS-CGK-PALRETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaRFFhkfLRDI 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 572 LVLSTalfgKPPFKNVIVNGLVLA-------------------------------SDGQKMSKRKKNYPDPGLIVQSYGA 620
Cdd:TIGR00396 550 GYVNT----KEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGA 625
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 621 DALRLYLI-NSPVvrAENLRFKEEGVRdvlkdvflpwyNAYRFLvQNVQRLQKEEGVEFLYNERTSSVSNNIMDKWIQSF 699
Cdd:TIGR00396 626 DALRLFIMfMGPI--AASLEWNESGLE-----------GARRFL-DRVWNLVYEITGELDAASLTVTALEEAQKELRRDV 691
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 700 TQSLIQFFRDEMGAYRLYTVVPKLVKFVDMLtnwyvrmnrrrlkgESGSEDCVrALETLFSVLfsmcRLMAPFTPFITEL 779
Cdd:TIGR00396 692 HKFLKKVTEDLEKRESFNTAISAMMELLNKL--------------YKAKKEAL-MLEYLKGFV----TVLSPFAPHLAEE 752
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 780 MYQNLRHLldpaaveekdTGSIHYLMLPQVRESLIDQriesavSRMQSVIELGRVIRDRKTLPIKYPLKEVVVI-HQDPE 858
Cdd:TIGR00396 753 LWEKLGSE----------PFIIDNAKWPVVDETALVE------DKTLIVVQVNGKFRAKITVPKDADEEQVEELaKQDPE 816
|
....*
gi 940373610 859 ALTDI 863
Cdd:TIGR00396 817 VKKYL 821
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
21-836 |
1.38e-30 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 131.17 E-value: 1.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 21 FWQKNDCFQECLKQSKsrPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVEYEIDKSL 100
Cdd:PLN02381 112 WWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 101 NIKGPEDVMKMGIEEYNKQcrsiVMRYADEWE----NSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGV 176
Cdd:PLN02381 190 MRERHLTRHDIGREEFVSE----VWKWKDEYGgtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDI 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 177 KVMPFSTACNTPLSNFEANqnYKDVQDPSVIvNFPLLEDPsVSLIAWTTTPWTLPSNLAlcvnpELIYvrvkdnSSQKIY 256
Cdd:PLN02381 266 RLVNWDCTLRTAISDVEVD--YIDIKERTLL-KVPGYDKP-VEFGVLTSFAYPLEGGLG-----EIVV------ATTRIE 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 257 IMMEARLVALFKSDSEYTILE-RFPGKTLKGKKYKplfeyfIKCKetgafSVVMD-NYvrdddGTGVVHQAPYFGADDYR 334
Cdd:PLN02381 331 TMLGDTAIAIHPDDERYKHLHgKFAVHPFNGRKLP------IICD-----AILVDpNF-----GTGAVKITPAHDPNDFE 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 335 V----CMEYDIIQRDSAPICPVDPSgiftpevtHFAGQYVKDADKNIIKWLKENGRLVSASSFKHSYPFCWRSD---TPL 407
Cdd:PLN02381 395 VgkrhNLEFINIFTDDGKINSNGGS--------EFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPM 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 408 IYkavPSWFIRVEHMVEKLLD-----NNSKCYWVP-EFVKEKRfgNWLRDARDWAVSRNRYWGTPIPLW---VSDDFEEV 478
Cdd:PLN02381 467 IK---PQWFVNCSSMAKQALDaaidgENKKLEFIPkQYLAEWK--RWLENIRDWCISRQLWWGHRIPAWyvtLEDDQLKE 541
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 479 VCVGS----MAELEEltgikvtDLHRESidGLTIPSRcgKGQLRRVSEVFDCWFESGSMPYAQVHYPfENRREFEDAFPA 554
Cdd:PLN02381 542 LGSYNdhwvVARNES-------DALLEA--SQKFPGK--KFELSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPT 609
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 555 DFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDP----------GLI---------- 614
Cdd:PLN02381 610 SVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPlevingisleGLHkrleegnldp 689
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 615 -----------------VQSYGADALRLYLInSPVVRAENLRFkeegvrDVLKDV-FLPW----YNAYRFLVQNVqrlqk 672
Cdd:PLN02381 690 kelvvakegqkkdfpngIAECGTDALRFALV-SYTAQSDKINL------DILRVVgYRQWcnklWNAVRFAMSKL----- 757
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 673 eeGVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKL-----VKFVDMltnwYVRMNRRRLKGESG 747
Cdd:PLN02381 758 --GDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVyswwqYQFCDV----FIEAIKPYFAGDNP 831
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 748 SEDCVR--ALETLFSVLFSMCRLMAPFTPFITELMYQNLrhlldPAAVEEKDTGSIHYLMLPQVRESLIDQRIESAVSRM 825
Cdd:PLN02381 832 EFASERaaAQDTLWICLDTGLRLLHPFMPFVTEELWQRL-----PQPKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLV 906
|
890
....*....|.
gi 940373610 826 QSVIELGRVIR 836
Cdd:PLN02381 907 LSTVKCLRSLR 917
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
693-851 |
2.02e-23 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 97.47 E-value: 2.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 693 DKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYVRMNRRRLKGESGSEdcvRALETLFSVLFSMCRLMAP 771
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 772 FTPFITELMYQNLrhlldpaaveekdtgSIHYLMLPQvRESLIDQRIESAVSRMQSVIELGRVIRDRKTLPIKYPLKEVV 851
Cdd:pfam08264 78 FMPFITEELWQKE---------------SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
4-626 |
2.23e-21 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 101.05 E-value: 2.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 4 AVPESIHFPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLP-HYGHILAGTIKDIVTRFAHQNGFHVERR 82
Cdd:PLN02563 75 AAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 83 FGWDCHGLPVE-YEIDKSLNikgPEDVMKMGIEEYNKQCRSIVMRYadEWENSVrrmgrwidfrndyKTLYPWFMETVWW 161
Cdd:PLN02563 155 MGWDAFGLPAEqYAIETGTH---PKITTLKNIARFRSQLKSLGFSY--DWDREI-------------STTEPEYYKWTQW 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 162 VFKQLYDSGLVYRGVKVMPFSTACNTPLSNFE----------------------------ANQNYKDVQD---PSVI--- 207
Cdd:PLN02563 217 IFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpvirkpmrqwmlkitayADRLLEDLDDldwPESIkem 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 208 ------------VNFPLLEDPSVS----LIAWTTTPWTLPSNLALCVNPELIYVRVKDNSSQKIYImMEARLVALFKSDS 271
Cdd:PLN02563 297 qrnwigrsegaeLDFSVLDGEGKErdekITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAV-EEYVDAASRKSDL 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 272 EYTILERFPGKTLKGKkykplfeyFIKCKETG-AFSVVMDNYVRDDDGTGVVHQAPYFGADDYRVCMEYDIiqrdsaPIC 350
Cdd:PLN02563 376 ERTELQKEKTGVFTGS--------YAINPATGeAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDL------PIK 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 351 PV---------DPSGIFTPEVT---------HFAGQYVKDADKNIIKWLKENGrlvsASSFKHSYpfcwrsdtpliykav 412
Cdd:PLN02563 442 WVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIEWLEETG----NGKKKVNY--------------- 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 413 pswfirvehmveKLldnnskcywvpefvkekrfgnwlrdaRDWAVSRNRYWGTPIPLWVSDDFEEVVCVgSMAELEeltg 492
Cdd:PLN02563 503 ------------KL--------------------------RDWLFARQRYWGEPIPVVFLEDSGEPVPV-PESDLP---- 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 493 ikvtdLHRESIDGLTiPSRCGKGQLRR----VSEVFDC---WF--ESGSMP--------YAQVHYPfENRREFEDA---- 551
Cdd:PLN02563 540 -----LTLPELDDFT-PTGTGEPPLAKavswVNTVDPSsgkPArrETNTMPqwagscwyYLRFMDP-KNSNALVDKekek 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 552 --FPADFIAEGIDQ-------TRGW---FYTLLVLSTalfgKPPFKNVIVNGLVLA---------SDGQ----------- 599
Cdd:PLN02563 613 ywMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSDGEyvsadtadrlg 688
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 940373610 600 ----------------------------------KMSKRKKNYPDPGLIVQSYGADALRLY 626
Cdd:PLN02563 689 elqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY 749
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
453-822 |
1.06e-18 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 92.42 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 453 RDWAVSRNRYWGTPIPLWVSDDFEEVvcvgsmA-----------ELEELTGIKVTDLHResidgltIPS-------RCGK 514
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCEDCGVV------PvpedqlpvelpEDVDFDPTGGSPLAR-------APEwvnvtcpKCGG 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 515 gQLRRVSEVFDCWFESgS---MPYAQVHYpfenrrefeDAFPADFIAE----GIDQ--------------TRgwFYT-LL 572
Cdd:COG0495 487 -PARRETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTkVL 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 573 ----VLSTalfgKPPFKNVIVNGLV--LASDG------QKMSKRKKNYPDPGLIVQSYGADALRLYLI-NSPVVRaeNLR 639
Cdd:COG0495 554 rdlgLVSF----DEPFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLE 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 640 FKEEGVRdvlkdvflpwyNAYRFLvQNVQRLQkeegVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTV 719
Cdd:COG0495 628 WSDSGVE-----------GAYRFL-NRVWRLV----VDEAEALKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTA 691
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 720 VPKLVKFVDMLTnwyvrmnrrRLKGESGSEDCVR--ALETLfsvlfsmCRLMAPFTPFITELMYQNLRHlldpaaveekd 797
Cdd:COG0495 692 IAALMELVNALY---------KAKDSGEADRAVLreALETL-------VLLLAPFAPHIAEELWERLGH----------- 744
|
410 420
....*....|....*....|....*.
gi 940373610 798 TGSIHYLMLPQVRES-LIDQRIESAV 822
Cdd:COG0495 745 EGSVADAPWPEADEAaLVEDEVTIVV 770
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
657-784 |
1.67e-15 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 74.52 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 657 YNAYRFLVQNVQRLQKEEgveflynerTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYV 735
Cdd:cd07962 17 WNAARFVLMNLEDDDEPE---------EDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 940373610 736 RMNRRRLKGESGSEDCVrALETLFSVLFSMCRLMAPFTPFITELMYQNL 784
Cdd:cd07962 88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
415-628 |
7.18e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 74.21 E-value: 7.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 415 WFIRVEH--MVEKLLDNNSKCYWVPEFVKeKRFGNWLrdardwAVSRNRYWGTPIPL-WVSDDFeevvcVGS---MAele 488
Cdd:cd00812 132 WFLKYSEteWKEKLLKDLEKLDGWPEEVR-AMQENWI------GCSRQRYWGTPIPWtDTMESL-----SDStwyYA--- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 489 eltgiKVTDLHRESIDGLTIPSrcgkgqlrrvsevfdcwfesgsmpyaqvhypfENRREFEDAFPADFIAEGIDqtrgwf 568
Cdd:cd00812 197 -----RYTDAHNLEQPYEGDLE--------------------------------FDREEFEYWYPVDIYIGGKE------ 233
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 940373610 569 ytLLVL--------STALFGKP-----PFKNVIVNGLVLAsDGQKMSKRKKNYPDPGLIVQSYGADALRLYLI 628
Cdd:cd00812 234 --HAPNhllysrfnHKALFDEGlvtdePPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
870-1039 |
4.81e-13 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 69.04 E-value: 4.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 870 ILEELNVRQLTLSTDKDRYgIRLRAEPDHMVLGKRLKGAFKSVTASIKELKSEELEEFQKTGC--IVVDGH--DLREEDL 945
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 946 RLmytfdQSSGSASqYEAHSDAQVLVLLDVTPDQAMLDEGVAREVINRIQKLRKKGHLVPSDEITVFYRcqpAGEYLHQV 1025
Cdd:pfam19302 83 LV-----TRQGKEG-LAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVS---GNEMLEAA 153
|
170
....*....|....
gi 940373610 1026 IEAHTDFILATTKA 1039
Cdd:pfam19302 154 IEKFEDYIKKETLA 167
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-175 |
1.06e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 70.35 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 48 PFATGLPHYGHILAGTIKDIVTRFAHQNGFHVERRFGWDCHGLPVE-YEIDKSLNikgPEDvmkmgIEEYNkqcrsivmr 126
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAEnAAIKIGRD---PED-----WTEYN--------- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 940373610 127 yADEWENSVRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRG 175
Cdd:cd00812 72 -IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
371-628 |
2.37e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 63.32 E-value: 2.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 371 KDADKNIIKWLKENGRLVSASsfkHSYPFCWRSDTPL-IYKAVPSWFIRV---EHMVEKLLDNNSKCYWVPEFVKEKRfg 446
Cdd:cd00814 98 KEIVQEFFKKLYENGYIYEGE---YEGLYCVSCERFLpEWREEEHYFFRLskfQDRLLEWLEKNPDFIWPENARNEVL-- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 447 NWLRDA-RDWAVSR-NRYWGTPIPlwvsdDFEevvcvgsmaeleeltgikvtdlhresidgltipsrcgkgqlrrvSEVF 524
Cdd:cd00814 173 SWLKEGlKDLSITRdLFDWGIPVP-----LDP--------------------------------------------GKVI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 525 DCWFE------SGSMPYAQvhyPFENRREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLSTAlfGKPPFKNVIVNGLV 593
Cdd:cd00814 204 YVWFDaligyiSATGYYNE---EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA--GLPLPTRIVAHGYL 274
|
250 260 270
....*....|....*....|....*....|....*
gi 940373610 594 LAsDGQKMSKRKKNYPDPGLIVQSYGADALRLYLI 628
Cdd:cd00814 275 TV-EGKKMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
398-628 |
1.10e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 62.44 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 398 PFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDN-NSKCYWVPEFVKEKRfgNWLRDA-RDWAVSRNRYWGTPIPlwvsdDF 475
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLEWiEENPDIQPEVRNEVL--SWLKEGlQDLSISRDFDWGIPVP-----GD 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 476 EevvcvgsmaeleeltgikvtdlhresidgltipsrcGKgqlrrvseVFDCWFE------SGSMPYAQVHYPFENRREF- 548
Cdd:COG0143 242 P------------------------------------GK--------VFYVWFDaligyiSATKGYADDRGLPEDFEKYw 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 549 --EDAFPADFIaeGIDQTRgwFYTLL---VLSTAlfGKPPFKNVIVNGLVLaSDGQKMSKRKKNYPDPGLIVQSYGADAL 623
Cdd:COG0143 278 paPDTELVHFI--GKDIIR--FHAIIwpaMLMAA--GLPLPKKVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDAL 350
|
....*
gi 940373610 624 RLYLI 628
Cdd:COG0143 351 RYYLL 355
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
398-628 |
5.65e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 56.81 E-value: 5.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 398 PFCWRSDTPLIYKAVPSWFIRVEHMVEKLLD---NNskcywvPEFVK-EKRFG---NWLRD-ARDWAVSRNRY-WGTPIP 468
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLElyeAN------PDFIQpASRRNeviSFVKSgLKDLSISRTNFdWGIPVP 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 469 lwvsDDFEEVVCVGSMAeleeLTGikvtdlhresidgltipsrcgkgqlrrvsevfdcwFESGSM-PYAQVhypfENRRE 547
Cdd:PRK11893 216 ----GDPKHVIYVWFDA----LTN-----------------------------------YLTALGyPDDEE----LLAEL 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 548 FEDAFPAD--FIaeGIDQTR----GWFYTLLVLstalfGKPPFKNVIVNG-LVLasDGQKMSKRKKNYPDPGLIVQSYGA 620
Cdd:PRK11893 249 FNKYWPADvhLI--GKDILRfhavYWPAFLMAA-----GLPLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEYGV 319
|
....*...
gi 940373610 621 DALRLYLI 628
Cdd:PRK11893 320 DAVRYFLL 327
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
398-631 |
7.29e-08 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 56.14 E-value: 7.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 398 PFCWRSDTPLIYKAVPSWFIRV---EHMVEKLLDNNSKcYWVPEFVKEKRfgNWLRDA-RDWAVSRNRYWGTPIPlwvsd 473
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLskfQDKLREWIEENNP-EWPENVKNMVL--EWLKEGlKDRAISRDLDWGIPVP----- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 474 DFEevvcvgsmaeleeltgikvtdlhresidgltipsrcGKgqlrrvseVFDCWFESgSMPY-AQVHYPFENRREFEDAF 552
Cdd:pfam09334 239 GAE------------------------------------GK--------VFYVWLDA-PIGYiSATKELSGNEEKWKEWW 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 553 PAD-------FIaeGIDQTRgwFYTLL---VLSTALFGKPpfKNVIVNGLVLAsDGQKMSKRKKNYPDPGLIVQSYGADA 622
Cdd:pfam09334 274 PNDpdtelvhFI--GKDIIY--FHTIFwpaMLLGAGYRLP--TTVFAHGYLTY-EGGKMSKSRGNVVWPSEALDRFPPDA 346
|
250
....*....|
gi 940373610 623 LRLYLI-NSP 631
Cdd:pfam09334 347 LRYYLArNRP 356
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
642-773 |
9.45e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 51.74 E-value: 9.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 642 EEGVRDVLKDvFLPWYNAYRFLVQNVQRLQKEEGVEFLynertssvsnNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVP 721
Cdd:cd07375 1 EERLKQARAF-LNRLYRLLSFFRKALGGTQPKWDNELL----------EEADRELLARLQEFIKRTTNALEALDPTTAVQ 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 940373610 722 KLVKFVDMLtNWYVRMNRRRLKGESGSEDCVRALETLFSVLFsmcRLMAPFT 773
Cdd:cd07375 70 ELFKFTNEL-NWYLDELKPALQTEELREAVLAVLRAALVVLT---KLLAPFT 117
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
540-628 |
8.22e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 50.18 E-value: 8.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 540 YPFENRREFEDAFPADFIAEGIDQTRgwFYT------LLVLstalfGKPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPGL 613
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
|
90
....*....|....*
gi 940373610 614 IVQSYGADALRLYLI 628
Cdd:PRK12267 313 LVDRYGLDALRYYLL 327
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
692-831 |
1.94e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 43.67 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 692 MDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLVKFV-DMLTNWYVRMNRRRL---KGESGSEDCVRAleTLFSVLFSMCR 767
Cdd:cd07960 45 LDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLDIIKDRLycdAKDSLERRSAQT--VLYHILDALLK 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 940373610 768 LMAPFTPFITELMYQNLrhlldPAAVEEKdtgSIHYLMLPQVRESLIDqriESAVSRMQSVIEL 831
Cdd:cd07960 123 LLAPILPFTAEEVWEHL-----PGEKKEE---SVFLEDWPELPEEWKD---EELEEKWEKLLAL 175
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
572-630 |
3.76e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 43.34 E-value: 3.76e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 940373610 572 LVLSTALFGKPPFKNVIVNGLVLAsDGQKMSKRKKNY---PDpglIVQSYGADALRLYLINS 630
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFitvRD---ALKKYDPEVLRLALLSS 204
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
47-185 |
2.03e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 42.18 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 47 PPFATGLPHYGHilAGT--IKDIVTRFAHQNGFHVerRF--GWDCHGLPVEyeidkslnikgpedvmKMGIEEyNKQCRS 122
Cdd:PRK11893 9 IYYPNGKPHIGH--AYTtlAADVLARFKRLRGYDV--FFltGTDEHGQKIQ----------------RKAEEA-GISPQE 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940373610 123 IVMRYADEWENSVRRMgrwiDFRNDY--KTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPFSTAC 185
Cdd:PRK11893 68 LADRNSAAFKRLWEAL----NISYDDfiRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRC 128
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
669-784 |
2.27e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 39.11 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 669 RLQK-EEGVEFLYNERTSSVSNNIMDKWIQSFTQSLIQFFRDEMGAYRLYTVVPKLvkFVDMLT--NWYvrmnRRRLKGE 745
Cdd:cd07959 12 RLERfYELAEELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWY----RERGGAG 85
|
90 100 110
....*....|....*....|....*....|....*....
gi 940373610 746 SGSEdcvraleTLFSVLFSMCRLMAPFTPFITELMYQNL 784
Cdd:cd07959 86 MNKD-------LLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
575-650 |
6.21e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 40.04 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940373610 575 STALFGKPPFKNVIVNGLVLAsDGQKMSKRKKNY---PDpglIVQSYGADALRLYLI----NSPvvraenLRFKEEGVRD 647
Cdd:pfam01406 229 SEAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFftiRD---VLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQ 298
|
...
gi 940373610 648 VLK 650
Cdd:pfam01406 299 AKS 301
|
|
| |
