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    lrrc3b leucine rich repeat containing 3B [ Danio rerio (zebrafish) ]

    Gene ID: 100037364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrrc3bprovided by ZNC
    Official Full Name
    leucine rich repeat containing 3Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-55
    See related
    Ensembl:ENSDARG00000063215 AllianceGenome:ZFIN:ZDB-GENE-070410-55
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162270
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in nervous system. Orthologous to human LRRC3B (leucine rich repeat containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrrc3b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (1605713..1630115)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (1659316..1674612)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 20 Neighboring gene solute carrier family 45 member 4 Neighboring gene kelch-like family member 7 Neighboring gene DENN/MADD domain containing 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The evolutionary origin of nodal-related genes in teleosts. Fan X, et al. Dev Genes Evol, 2007 Dec. PMID 17992538
    2. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Staudt N, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25490391, Free PMC Article
    3. Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway. Yang R, et al. Cell Death Differ, 2021 Jan. PMID 32709934, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089516.1 → NP_001082985.1  leucine-rich repeat-containing protein 3B precursor

      See identical proteins and their annotated locations for NP_001082985.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133927
      UniProtKB/Swiss-Prot
      A3KNN3
      Related
      ENSDARP00000086615.4, ENSDART00000092183.5
      Conserved Domains (4) summary
      smart00013
      Location:34 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:70 → 93
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:94 → 132
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:73 → 129
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      1605713..1630115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173724.5 → XP_005173781.1  leucine-rich repeat-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_005173781.1

      UniProtKB/Swiss-Prot
      A3KNN3
      Conserved Domains (4) summary
      smart00013
      Location:34 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:70 → 93
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:94 → 132
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:73 → 129
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KNN3.1 GenPept UniProtKB/Swiss-Prot:A3KNN3

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