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Conserved domains on  [gi|148235375|ref|NP_001082985|]
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leucine-rich repeat-containing protein 3B precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183727)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
73-129 9.73e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 9.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148235375   73 LQLDRNHISLVPDRIFHGLRMLRRLNLSHNAVETLGEGAFIGLEgSLEVLDLSYNRI 129
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-72 9.65e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 9.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148235375    34 CPKGCTCqrsesppHGLNVTCSLSRLKEIPPDVPPDTQL 72
Cdd:smart00013   2 CPAPCNC-------SGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
73-129 9.73e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 9.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148235375   73 LQLDRNHISLVPDRIFHGLRMLRRLNLSHNAVETLGEGAFIGLEgSLEVLDLSYNRI 129
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-142 6.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  54 CSLSRLKEIPPDVPPDTQL--LQLDRNHISLVPDRIFhGLRMLRRLNLSHNAVETLGEgAFIGLEgSLEVLDLSYNRITS 131
Cdd:COG4886  143 LSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTD 219

                         90
                 ....*....|.
gi 148235375 132 VhKDAFARLKA 142
Cdd:COG4886  220 L-PEPLANLTN 229
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
59-150 6.46e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  59 LKEIPPDVPPDTQLLQLDRNHISLVPDRIfhgLRMLRRLNLSHNAVETLGEgafiGLEGSLEVLDLSYNRITSV-----H 133
Cdd:PRK15370 337 LTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPE----NLPAALQIMQASRNNLVRLpeslpH 409

                         90
                 ....*....|....*..
gi 148235375 134 KDAFARLKARVVVDNNP 150
Cdd:PRK15370 410 FRGEGPQPTRIIVEYNP 426
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-72 9.65e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 9.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148235375    34 CPKGCTCqrsesppHGLNVTCSLSRLKEIPPDVPPDTQL 72
Cdd:smart00013   2 CPAPCNC-------SGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR smart00370
Leucine-rich repeats, outliers;
117-138 4.70e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 4.70e-03
                           10        20
                   ....*....|....*....|..
gi 148235375   117 GSLEVLDLSYNRITSVHKDAFA 138
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAFQ 23
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-132 5.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  73 LQLDRNHISlvpdRI--FHGLRMLRRLNLSHNAVETLgEG----------------------------AFIGLEGSLEVL 122
Cdd:cd21340   51 LYLQNNQIE----KIenLENLVNLKKLYLGGNRISVV-EGlenltnleelhienqrlppgekltfdprSLAALSNSLRVL 125

                         90
                 ....*....|
gi 148235375 123 DLSYNRITSV 132
Cdd:cd21340  126 NISGNNIDSL 135
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
73-129 9.73e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 9.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148235375   73 LQLDRNHISLVPDRIFHGLRMLRRLNLSHNAVETLGEGAFIGLEgSLEVLDLSYNRI 129
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
94-142 5.39e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 5.39e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 148235375   94 LRRLNLSHNAVETLGEGAFIGLEgSLEVLDLSYNRITSVHKDAFARLKA 142
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPS 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-142 6.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  54 CSLSRLKEIPPDVPPDTQL--LQLDRNHISLVPDRIFhGLRMLRRLNLSHNAVETLGEgAFIGLEgSLEVLDLSYNRITS 131
Cdd:COG4886  143 LSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTD 219

                         90
                 ....*....|.
gi 148235375 132 VhKDAFARLKA 142
Cdd:COG4886  220 L-PEPLANLTN 229
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-132 4.05e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  54 CSLSRLKEIPPDVPPDTQL--LQLDRNHISLVPDRIFhGLRMLRRLNLSHNAVETLGEgAFIGLEgSLEVLDLSYNRITS 131
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPE-PLANLT-NLETLDLSNNQLTD 242


                 .
gi 148235375 132 V 132
Cdd:COG4886  243 L 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-150 6.86e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 6.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  58 RLKEIPPDVPPDTQL--LQLDRNHISLVPDRIfHGLRMLRRLNLSHNAVETLGEgafIGLEGSLEVLDLSYNRITSVHKD 135
Cdd:COG4886  193 QITDLPEPLGNLTNLeeLDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPPL 268

                         90
                 ....*....|....*.
gi 148235375 136 A-FARLKaRVVVDNNP 150
Cdd:COG4886  269 AnLTNLK-TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-131 7.51e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 7.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148235375  58 RLKEIPPDVPPDTQL--LQLDRNHISLVPDriFHGLRMLRRLNLSHNAVETLGEGAFIGlegSLEVLDLSYNRITS 131
Cdd:COG4886  216 QLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
50-102 2.69e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 2.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148235375   50 LNVTCSlsRLKEIPPDV---PPDTQLLQLDRNHISLVPDRIFHGLRMLRRLNLSHN 102
Cdd:pfam13855   6 LDLSNN--RLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
59-150 6.46e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  59 LKEIPPDVPPDTQLLQLDRNHISLVPDRIfhgLRMLRRLNLSHNAVETLGEgafiGLEGSLEVLDLSYNRITSV-----H 133
Cdd:PRK15370 337 LTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPE----NLPAALQIMQASRNNLVRLpeslpH 409

                         90
                 ....*....|....*..
gi 148235375 134 KDAFARLKARVVVDNNP 150
Cdd:PRK15370 410 FRGEGPQPTRIIVEYNP 426
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-132 2.76e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.99  E-value: 2.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148235375  57 SRLKEIPPDVPPDTQLLQLDRNHISLVPDRIFHGlrmLRRLNLSHNAVETLGEgafiGLEGSLEVLDLSYNRITSV 132
Cdd:PRK15370 230 NQLTSIPATLPDTIQEMELSINRITELPERLPSA---LQSLDLFHNKISCLPE----NLPEELRYLSVYDNSIRTL 298
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-141 3.54e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  43 SESPPHGLNVTCSLSRLKEIPPDVPPDTQLLQLDR-NHISLVPDRIFHGLRMLRRLNLSHNAVETLGEgaFIGLEGSLEV 121
Cdd:COG4886   63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKE 140

                         90       100
                 ....*....|....*....|
gi 148235375 122 LDLSYNRITSVHkDAFARLK 141
Cdd:COG4886  141 LDLSNNQLTDLP-EPLGNLT 159
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-72 9.65e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 9.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148235375    34 CPKGCTCqrsesppHGLNVTCSLSRLKEIPPDVPPDTQL 72
Cdd:smart00013   2 CPAPCNC-------SGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR smart00370
Leucine-rich repeats, outliers;
117-138 4.70e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 4.70e-03
                           10        20
                   ....*....|....*....|..
gi 148235375   117 GSLEVLDLSYNRITSVHKDAFA 138
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
117-138 4.70e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 4.70e-03
                           10        20
                   ....*....|....*....|..
gi 148235375   117 GSLEVLDLSYNRITSVHKDAFA 138
Cdd:smart00369   2 PNLRELDLSNNQLSSLPPGAFQ 23
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-132 5.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235375  73 LQLDRNHISlvpdRI--FHGLRMLRRLNLSHNAVETLgEG----------------------------AFIGLEGSLEVL 122
Cdd:cd21340   51 LYLQNNQIE----KIenLENLVNLKKLYLGGNRISVV-EGlenltnleelhienqrlppgekltfdprSLAALSNSLRVL 125

                         90
                 ....*....|
gi 148235375 123 DLSYNRITSV 132
Cdd:cd21340  126 NISGNNIDSL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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