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    slc34a2b solute carrier family 34 member 2b [ Danio rerio (zebrafish) ]

    Gene ID: 359838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc34a2bprovided by ZNC
    Official Full Name
    solute carrier family 34 member 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030709-1
    See related
    Ensembl:ENSDARG00000036864 AllianceGenome:ZFIN:ZDB-GENE-030709-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NaPi-IIb2; wu:fi68d06
    Summary
    Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane. Is expressed in several structures, including digestive system; endoderm; optic vesicle; otic placode; and otic vesicle. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc34a2b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (1075252..1106138)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (1068952..1094122)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:zfos-905g2.1 Neighboring gene zgc:113423 Neighboring gene protein FAM13A-like Neighboring gene uncharacterized LOC137489066 Neighboring gene protein sel-1 homolog 3 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene proteasome 20S subunit beta 11b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters. Werner A, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Dec 1. PMID 27784684
    2. Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAs. Carlile M, et al. Physiol Genomics, 2008 Jun 12. PMID 18413783
    3. Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer. Piatek MJ, et al. PLoS One, 2017. PMID 28542524, Free PMC Article
    4. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables sodium:phosphate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:phosphate symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular phosphate ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphate ion transport IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium-dependent phosphate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 34 member 2b
    Names
    solute carrier family 34 (sodium phosphate), member 2b
    solute carrier family 34 (type II sodium/phosphate cotransporter), member 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182877.2 → NP_878297.1  solute carrier family 34 member 2b

      See identical proteins and their annotated locations for NP_878297.1

      Status: PROVISIONAL

      Source sequence(s)
      AF297180
      UniProtKB/TrEMBL
      Q9DDS6
      Related
      ENSDARP00000139464.2, ENSDART00000159263.2
      Conserved Domains (2) summary
      TIGR01013
      Location:90 → 585
      2a58; Phosphate:Na+ Symporter (PNaS) Family
      pfam02690
      Location:398 → 455
      Na_Pi_cotrans; Na+/Pi-cotransporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      1075252..1106138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469757.2 → XP_021325432.1  solute carrier family 34 member 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9P515
      Conserved Domains (1) summary
      TIGR01013
      Location:90 → 585
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    2. XM_068216694.1 → XP_068072795.1  solute carrier family 34 member 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9P515
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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