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    tle2a TLE family member 2, transcriptional corepressor a [ Danio rerio (zebrafish) ]

    Gene ID: 565013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tle2aprovided by ZNC
    Official Full Name
    TLE family member 2, transcriptional corepressor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2826
    See related
    Ensembl:ENSDARG00000042484 AllianceGenome:ZFIN:ZDB-GENE-030131-2826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tle2; fc18h03; sb:eu408; sb:eu1034; wu:fb96a10; wu:fc18h03; si:ch211-81i17.1
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in oocyte; telencephalon; and unfertilized egg. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tle2a in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (21618259..21667852)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (21593148..21642860)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 2b Neighboring gene transfer RNA glutamine (anticodon UUG) Neighboring gene TLE family member 2, transcriptional corepressor b Neighboring gene TLE family member 5, transcriptional modulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Duplicated members of the Groucho/Tle gene family in fish. Aghaallaei N, et al. Dev Dyn, 2005 Sep. PMID 16059907
    2. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article
    3. Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. He M, et al. PLoS Biol, 2020 Jul. PMID 32702011, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 2a
    Names
    groucho-related gene 4
    transducin like enhancer of split 2a
    transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130604.2 → NP_001124076.1  transducin-like enhancer protein 2a

      See identical proteins and their annotated locations for NP_001124076.1

      Status: VALIDATED

      Source sequence(s)
      BX569795, BX649200, CR936480
      UniProtKB/TrEMBL
      A0A8M1NI60, B3DJR5
      Related
      ENSDARP00000117865.2, ENSDART00000133939.3
      Conserved Domains (4) summary
      COG2319
      Location:517 → 809
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:519 → 808
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:33 → 162
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:528 → 567
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      21618259..21667852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170480.5 → XP_005170537.1  transducin-like enhancer protein 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHT3
      Conserved Domains (4) summary
      COG2319
      Location:502 → 794
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:504 → 793
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:33 → 162
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:513 → 552
      7WD40; WD40 repeat [structural motif]

    2. XM_068216338.1 → XP_068072439.1  transducin-like enhancer protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M1NI60, B3DJR5

    3. XM_009296271.4 → XP_009294546.1  transducin-like enhancer protein 2a isoform X5

      UniProtKB/TrEMBL
      A0A8M3B5J1
      Conserved Domains (4) summary
      COG2319
      Location:492 → 784
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:494 → 783
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:33 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:503 → 542
      7WD40; WD40 repeat [structural motif]

    4. XM_068216339.1 → XP_068072440.1  transducin-like enhancer protein 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BHU5

    5. XM_068216341.1 → XP_068072442.1  transducin-like enhancer protein 2a isoform X6

    6. XM_068216340.1 → XP_068072441.1  transducin-like enhancer protein 2a isoform X4

      UniProtKB/TrEMBL
      A0A8M2BI83

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395104.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      327410..369150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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